Spink8 (serine peptidase inhibitor, Kazal type 8) - Rat Genome Database

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Gene: Spink8 (serine peptidase inhibitor, Kazal type 8) Rattus norvegicus
Analyze
Symbol: Spink8
Name: serine peptidase inhibitor, Kazal type 8
RGD ID: 1307150
Description: Orthologous to human SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301016; RGD1307150; serine protease inhibitor Kazal-type 8; similar to Esophagus cancer-related gene-2 protein precursor (ECRG-2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,814,062 - 109,828,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,817,365 - 109,828,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,432,824 - 115,444,454 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08113,632,004 - 113,643,634 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08111,474,809 - 111,486,437 (+)NCBIRnor_WKY
Rnor_6.08117,903,088 - 117,917,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,906,014 - 117,917,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,255,606 - 117,270,334 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,190,549 - 114,202,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,210,003 - 114,221,633 (+)NCBI
Celera8109,107,161 - 109,118,789 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Spink8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,814,062 - 109,828,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,817,365 - 109,828,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,432,824 - 115,444,454 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08113,632,004 - 113,643,634 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08111,474,809 - 111,486,437 (+)NCBIRnor_WKY
Rnor_6.08117,903,088 - 117,917,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,906,014 - 117,917,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,255,606 - 117,270,334 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,190,549 - 114,202,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,210,003 - 114,221,633 (+)NCBI
Celera8109,107,161 - 109,118,789 (+)NCBICelera
Cytogenetic Map8q32NCBI
SPINK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,306,842 - 48,333,661 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl348,306,842 - 48,333,661 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,348,332 - 48,375,151 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,323,340 - 48,344,835 (-)NCBINCBI36Build 36hg18NCBI36
Celera348,298,735 - 48,320,292 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,402,368 - 48,423,818 (-)NCBIHuRef
CHM1_1348,300,661 - 48,322,136 (-)NCBICHM1_1
T2T-CHM13v2.0348,334,609 - 48,361,763 (-)NCBIT2T-CHM13v2.0
Spink8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,641,271 - 109,655,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,641,348 - 109,655,701 (+)EnsemblGRCm39 Ensembl
GRCm389109,812,203 - 109,826,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,812,280 - 109,826,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,719,141 - 109,729,142 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,674,051 - 109,684,029 (+)NCBIMGSCv36mm8
Celera9109,536,212 - 109,546,212 (+)NCBICelera
Cytogenetic Map9F2NCBI
Spink8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542024,283,223 - 24,298,948 (+)NCBIChiLan1.0ChiLan1.0
SPINK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,304,505 - 49,327,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,304,505 - 49,327,704 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,219,663 - 48,249,064 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SPINK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,737,192 - 40,753,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,737,264 - 40,753,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,654,746 - 40,671,418 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02041,222,661 - 41,239,505 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2041,222,792 - 41,239,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,463,432 - 40,480,091 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,864,628 - 40,881,280 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,145,393 - 41,162,069 (+)NCBIUU_Cfam_GSD_1.0
LOC100739218
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12149,400,864 - 149,406,484 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,929,219 - 155,934,832 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,702,931 - 9,734,555 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl229,703,065 - 9,726,287 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041157,367,410 - 157,397,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473073,399,530 - 73,409,788 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink8
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:131
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000056180
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
D8Got353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,827,328 - 109,827,607 (+)MAPPERmRatBN7.2
Rnor_6.08117,916,156 - 117,916,434NCBIRnor6.0
Rnor_5.08117,268,669 - 117,268,947UniSTSRnor5.0
RGSC_v3.48114,200,513 - 114,200,791UniSTSRGSC3.4
Celera8109,117,124 - 109,117,402UniSTS
Cytogenetic Map8q32UniSTS
RH128679  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,828,819 - 109,828,989 (+)MAPPERmRatBN7.2
Rnor_6.08117,917,647 - 117,917,816NCBIRnor6.0
Rnor_5.08117,270,160 - 117,270,329UniSTSRnor5.0
RGSC_v3.48114,202,004 - 114,202,173UniSTSRGSC3.4
Celera8109,118,615 - 109,118,784UniSTS
RH 3.4 Map81114.89UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 14 3
Low 1 22 18 15 18 7 7 26 32 21 8 7
Below cutoff 35 23 4 23 1 4 44 3 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056180   ⟹   ENSRNOP00000053026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,817,365 - 109,828,994 (+)Ensembl
Rnor_6.0 Ensembl8117,906,014 - 117,917,842 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102714   ⟹   ENSRNOP00000088661
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,817,365 - 109,828,782 (+)Ensembl
RefSeq Acc Id: NM_001106860   ⟹   NP_001100330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,817,365 - 109,828,994 (+)NCBI
Rnor_6.08117,906,192 - 117,917,821 (+)NCBI
Rnor_5.08117,255,606 - 117,270,334 (+)NCBI
RGSC_v3.48114,190,549 - 114,202,178 (+)RGD
Celera8109,107,161 - 109,118,789 (+)RGD
Sequence:
RefSeq Acc Id: XM_008766512   ⟹   XP_008764734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,814,062 - 109,828,994 (+)NCBI
Rnor_6.08117,903,088 - 117,917,821 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595595   ⟹   XP_017451084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,814,063 - 109,828,994 (+)NCBI
Rnor_6.08117,903,089 - 117,917,821 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081246   ⟹   XP_038937174
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,817,774 - 109,828,994 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100330   ⟸   NM_001106860
- UniProtKB: D3ZHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764734   ⟸   XM_008766512
- Peptide Label: isoform X1
- UniProtKB: D3ZHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451084   ⟸   XM_017595595
- Peptide Label: isoform X1
- UniProtKB: D3ZHW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053026   ⟸   ENSRNOT00000056180
RefSeq Acc Id: XP_038937174   ⟸   XM_039081246
- Peptide Label: isoform X1
- UniProtKB: D3ZHW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088661   ⟸   ENSRNOT00000102714
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHW6-F1-model_v2 AlphaFold D3ZHW6 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307150 AgrOrtholog
BioCyc Gene G2FUF-29087 BioCyc
Ensembl Genes ENSRNOG00000037199 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000053026 ENTREZGENE
  ENSRNOP00000053026.2 UniProtKB/TrEMBL
  ENSRNOP00000088661.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056180 ENTREZGENE
  ENSRNOT00000056180.4 UniProtKB/TrEMBL
  ENSRNOT00000102714.1 UniProtKB/TrEMBL
InterPro Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal UniProtKB/TrEMBL
KEGG Report rno:301016 UniProtKB/TrEMBL
NCBI Gene 301016 ENTREZGENE
Pfam Kazal_1 UniProtKB/TrEMBL
PhenoGen Spink8 PhenoGen
PROSITE KAZAL_2 UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
UniProt A0A8I6A5J3_RAT UniProtKB/TrEMBL
  D3ZHW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Spink8  serine peptidase inhibitor, Kazal type 8  RGD1307150_predicted  similar to Esophagus cancer-related gene-2 protein precursor (ECRG-2) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307150_predicted  similar to Esophagus cancer-related gene-2 protein precursor (ECRG-2) (predicted)  LOC301016_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301016_predicted  similar to Esophagus cancer-related gene-2 protein precursor (ECRG-2) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL