Pls1 (plastin 1) - Rat Genome Database

Name: Pls1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pls1 (plastin 1) Rattus norvegicus

Analyze

Symbol:

Pls1

Name:

plastin 1

RGD ID:

1307142

Description:

Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including actin filament organization; inner ear receptor cell stereocilium organization; and intestinal D-glucose absorption. Predicted to act upstream of or within terminal web assembly. Predicted to be located in several cellular components, including brush border; stereocilium; and terminal web. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC315926; MGC189074; plastin 1 (I isoform); plastin-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLS1 (plastin 1)	HGNC	Ensembl, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pls1 (plastin 1 (I-isoform))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pls1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLS1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLS1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pls1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLS1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLS1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pls1 (plastin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPS29 (ribosomal protein S29)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PLS1 (plastin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pls1 (plastin 1 (I-isoform))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pls1 (plastin 1 (I isoform))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Fim	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAC6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	plst-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pls1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	105,196,312 - 105,306,252 (-)	NCBI		GRCr8
mRatBN7.2	8	96,316,703 - 96,426,592 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	96,317,849 - 96,385,195 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	101,983,678 - 102,015,932 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	100,182,931 - 100,215,183 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	98,021,875 - 98,054,127 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	103,557,361 - 103,659,625 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	103,557,364 - 103,608,913 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	103,008,357 - 103,110,153 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	100,825,543 - 100,858,153 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	100,845,099 - 100,913,858 (-)	NCBI
Celera	8	95,763,631 - 95,795,453 (-)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness (ISO)

autosomal dominant nonsyndromic deafness 76 (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

Liver Neoplasms (ISO)

sensorineural hearing loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-benzofuran (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrolein (ISO)

afimoxifene (ISO)

alpha-pinene (ISO)

amiodarone (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

Butylbenzyl phthalate (EXP)

caffeine (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

deguelin (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

glafenine (EXP)

GW 4064 (ISO)

inulin (ISO)

ivermectin (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (ISO)

N-nitrosodiethylamine (ISO)

naphthalene-1,5-diamine (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

piroxicam (ISO)

potassium chromate (ISO)

quercetin (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

temozolomide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IBA)

actin filament network formation (IBA)

auditory receptor cell stereocilium organization (ISO)

biological_process (ND)

intestinal D-glucose absorption (ISO)

microvillus assembly (ISO)

positive regulation of multicellular organism growth (ISO)

positive regulation of protein localization to plasma membrane (ISO)

regulation of microvillus length (ISO)

terminal web assembly (ISO)

vestibular receptor cell stereocilium organization (ISO)

Cellular Component

actin filament (IBA)

actin filament bundle (IBA)

brush border (ISO)

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

plasma membrane (IEA,ISO)

stereocilium (ISO)

terminal web (ISO)

Molecular Function

actin filament binding (IBA)

calcium ion binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Review series: The cell biology of hearing.	Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.

Additional References at PubMed

PMID:7655078	PMID:12477932	PMID:19056867	PMID:19321664	PMID:22114352	PMID:23376485

Genomics

Comparative Map Data

Pls1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	105,196,312 - 105,306,252 (-)	NCBI		GRCr8
mRatBN7.2	8	96,316,703 - 96,426,592 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	96,317,849 - 96,385,195 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	101,983,678 - 102,015,932 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	100,182,931 - 100,215,183 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	98,021,875 - 98,054,127 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	103,557,361 - 103,659,625 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	103,557,364 - 103,608,913 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	103,008,357 - 103,110,153 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	100,825,543 - 100,858,153 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	100,845,099 - 100,913,858 (-)	NCBI
Celera	8	95,763,631 - 95,795,453 (-)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

PLS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	142,596,393 - 142,713,664 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	142,596,393 - 142,713,664 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	142,315,235 - 142,432,506 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	143,825,034 - 143,915,191 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	143,825,041 - 143,915,199	NCBI
Celera	3	140,738,741 - 140,856,000 (+)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI
HuRef	3	139,687,922 - 139,805,221 (+)	NCBI		HuRef
CHM1_1	3	142,278,265 - 142,395,516 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	145,343,653 - 145,460,901 (+)	NCBI		T2T-CHM13v2.0

Pls1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	95,634,695 - 95,727,359 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	95,634,695 - 95,727,364 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	95,752,642 - 95,845,306 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	95,752,642 - 95,845,311 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	95,653,061 - 95,745,698 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	95,563,391 - 95,654,612 (-)	NCBI		MGSCv36	mm8
Celera	9	95,319,770 - 95,411,700 (-)	NCBI		Celera
Cytogenetic Map	9	E3.3	NCBI
cM Map	9	50.22	NCBI

Pls1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955508	3,213,646 - 3,260,554 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955508	3,215,304 - 3,324,240 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	140,490,165 - 140,623,025 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	140,494,897 - 140,627,757 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	139,629,825 - 139,747,080 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	147,221,909 - 147,338,600 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	147,289,205 - 147,338,600 (+)	Ensembl	panpan1.1		panPan2

PLS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	38,243,631 - 38,347,195 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	38,243,024 - 38,347,202 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	38,170,597 - 38,273,260 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	38,775,761 - 38,879,245 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	38,775,186 - 38,879,252 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	38,457,792 - 38,561,305 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	38,534,253 - 38,637,869 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	38,778,573 - 38,881,960 (+)	NCBI		UU_Cfam_GSD_1.0

Pls1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	77,466,080 - 77,583,189 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936540	4,205,844 - 4,323,120 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936540	4,205,871 - 4,323,121 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	83,308,007 - 83,434,128 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	83,307,692 - 83,434,133 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PLS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	47,919,807 - 48,031,158 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	47,919,823 - 48,003,805 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	20,854,232 - 20,965,494 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pls1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	19,163,783 - 19,302,222 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	19,164,360 - 19,302,369 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pls1
543 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	39
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000013209
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat

Markers in Region

RH134294

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	96,318,132 - 96,318,327 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	103,558,789 - 103,558,983	NCBI	Rnor6.0
Rnor_5.0	8	103,009,785 - 103,009,979	UniSTS	Rnor5.0
RGSC_v3.4	8	100,825,828 - 100,826,022	UniSTS	RGSC3.4
Celera	8	95,763,916 - 95,764,110	UniSTS
RH 3.4 Map	8	1056.7	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		29	29		29			14	35	11	11
Low		20	23	12	19	12			60		30
Below cutoff		22	5				8	8					8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000013209 ⟹ ENSRNOP00000013209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	96,317,849 - 96,385,195 (-)	Ensembl
Rnor_6.0 Ensembl	8	103,557,364 - 103,608,913 (-)	Ensembl

RefSeq Acc Id:

NM_001108178 ⟹ NP_001101648

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	105,197,454 - 105,229,339 (-)	NCBI
mRatBN7.2	8	96,317,848 - 96,349,733 (-)	NCBI
Rnor_6.0	8	103,558,504 - 103,596,278 (-)	NCBI
Rnor_5.0	8	103,008,357 - 103,110,153 (-)	NCBI
RGSC_v3.4	8	100,825,543 - 100,858,153 (-)	RGD
Celera	8	95,763,631 - 95,795,453 (-)	RGD

Sequence:

show sequence

CGGTAGCCTTTTCAGATCGCTCGCAGATGGCATCCTTCTTTGCAAAATGATCAACTTATCTGAA
CCAGACACGATTGACGAAAGAGCCATCAATAAGAAGAAGCTCACTCCGTTCACCGTGTCGGAAA
ACTTGAACCTAGCCCTGAATTCTGCTTCAGCCATCGGCTGCACCGTGGTCAACATCGGTGCTCA
GGATCTCAAGGAGGGAAAGCCCCACTTGGTCTTGGGGCTTCTCTGGCAGATCATCAAAGTTGGT
CTCTTTGCTGACATTGAGATTTCCAGGAATGAAGCCTTGATCGCGCTGCTAAAAGAAGGGGAGG
AGCTGGAGGAGCTGATGAAGCTGTCTCCTGAGGAACTGCTGCTGCGATGGGTGAACTACCATCT
GACCAATGCGGGGTGGCGCACCATCAGCAACTTCAGCCAGGACATTAAGGACTCAAAAGCCTAT
TTCCACCTCCTCAATCAGATTGCTCCCAAAGGTGACCGAGATGGTGGGTCTGCTGTAACCATTG
ATCTTTCGGGATTTAACGAGAAGAACGACCTGAAGCGTGCTGGATTCATGCTCCAGGAAGCAGA
TAAGCTTGGCTGCAGACAGTTTGTCACGCCTGCAGATGTGGTTTCAGGGAACCCTAAGCTAAAC
TTAGCCTTTGTAGCGAATCTTTTTAACACATACCCATGTCTCCACAAGCCTGACAACAATGACA
TTGATCTCAACTTACTGGAAGGAGAGAGCAAGGAAGAGAGGACATTTCGGAACTGGATGAATTC
ACTGGGTGTCAACCCATACATCAATCACTTGTACAGTGACCTCGCAGATGCCTTGGTGATCTTT
CAGCTCTATGAGATGATCCGCGTGCCAGTCAACTGGAACCATGTCAACAAGCCTCCCTACCCTG
CCCTTGGAGGGAACATGAAGAAGATTGAAAACTGCAACTACGCAGTTGAGCTCGGGAAGAACGA
GGCCAAATTCTCTTTGGTTGGTATCGCCGGACAGGACTTAAATGAAGGGAATGCAACACTTACC
CTGGCTCTGGTGTGGCAGTTGATGAGAAGATACACGCTGAAAGTTCTGTCAGACCTGGGAGAAG
GTGAAAAAGTCAGTGATGATATCATTATTAAATGGGTCAATCAGACCCTTAAAAGTGCAAATAA
AAGTACTTCTATTTCCAGCTTCAAGGATAAATCTATTAGTACAAGCTTGCCTGTCTTAGATCTA
ATAGATGCCATTGCACCAAATGCAGTCCGTCCGGAAATGATCAAGAGAGAACACTTGACTGACG
AAGACAAGCTGAACAATGCTAAATATGCCATTTCAGTTGCTCGGAAGATCGGCGCCCGGATATA
CGCGCTGCCTGATGACCTCGTGGAAGTGAAGCCGAAGATGGTGATGACTGTGTTTGCCTGCTTA
ATGGGAAAGGGACTGAACAGACTGAAATAATGAACCATGTACTGTGACCTGTCACATTACACGC
ATCGAACGTCTCAGTTTACAGAATTTTGAAATGTAGTGGGTATCAAATCAGAATATCTGTATGC
TCCAAACAGTTCTGTGTCCAGTAATGAATAATATCTTGTCCATACCAGTTAGAATTTGTCAATC
TATTTTTTAGATAACACAATTACCTTAACAATCAACACCAATTCAGGAATGTTTTCCTCAAGCT
GCTATTTCATAATTATTTTATTCCCTAAGAGTCTTACCAAAATAAGACTAATCATTCATTTTTC
ATGGCTCAAAAAAGACCTGTATAAAGTTTTGTCAGATCCTTCTATTAAATTTGTTTGGATTTTT
TTGATGTGTTGTTTAATTTTGATTAAAAATGTACCTAAAGTCGTATTCTAACTTTAATTTAATC
CTTTTGTTTTTCCTCCTTAACTATGTAAAGCAATCTAAAATTTTCTGTAAATTTCTATATCATA
TAAAAATTTAAAAGGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243574 ⟹ XP_006243636

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	105,196,312 - 105,292,487 (-)	NCBI
mRatBN7.2	8	96,316,703 - 96,412,828 (-)	NCBI
Rnor_6.0	8	103,557,361 - 103,659,625 (-)	NCBI
Rnor_5.0	8	103,008,357 - 103,110,153 (-)	NCBI

Sequence:

show sequence

CGCAGTGGCGCGAGCGCAGGGGCTAGGAGGCGGGCGAGAAGTAGCCGCAGCAGAGTGGACCAGA
CCAGCGGGCGCAGGGGTCTCGGGCAGTAGCTGCCGAACGGCCGCCGCAGATATAAAGACCTGAA
GCAGCCTTTCCAGTCTAACGATGGAAAACAGTACCACCACCATTTCTCGGGAGGAGCTTGAAGA
GCTACAGGAAGCGTTTAATAAAATAGATATTGACAACAGTGGATATGTGAGTGACTATGAACTT
CAGGACCTGTTTAAGGAAGCGAGTCTTCCTCTCCCTGGGTACAAGGTGCGAGAGATTGTGGAGA
AAATTTTAGTAGTTGCTGACAACAACAAAGATGGGAAAATCAGTTTTGAGGAGTTTGTGTCGCT
GATGCAAGAGTTAAAAAGCAAAGACATCAGCAAGACATTCCGGAAAATAATTAACAAAAGGGAA
GGGATCACTGCTATTGGGGGGACGTCATCCATCTCCAGCGAGGGCACCCAGCATTCTTATTCAG
AGGAAGAAAAAGTAGCTTTTGTTAACTGGATAAACAAAGCTCTGGAGAATGATGCAGACTGTAG
CCACCTCCTGCCCATGAACCCCAACGACGGTAGCCTTTTCAGATCGCTCGCAGATGGCATCCTT
CTTTGCAAAATGATCAACTTATCTGAACCAGACACGATTGACGAAAGAGCCATCAATAAGAAGA
AGCTCACTCCGTTCACCGTGTCGGAAAACTTGAACCTAGCCCTGAATTCTGCTTCAGCCATCGG
CTGCACCGTGGTCAACATCGGTGCTCAGGATCTCAAGGAGGGAAAGCCCCACTTGGTCTTGGGG
CTTCTCTGGCAGATCATCAAAGTTGGTCTCTTTGCTGACATTGAGATTTCCAGGAATGAAGCCT
TGATCGCGCTGCTAAAAGAAGGGGAGGAGCTGGAGGAGCTGATGAAGCTGTCTCCTGAGGAACT
GCTGCTGCGATGGGTGAACTACCATCTGACCAATGCGGGGTGGCGCACCATCAGCAACTTCAGC
CAGGACATTAAGGACTCAAAAGCCTATTTCCACCTCCTCAATCAGATTGCTCCCAAAGGTGACC
GAGATGGTGGGTCTGCTGTAACCATTGATCTTTCGGGATTTAACGAGAAGAACGACCTGAAGCG
TGCTGGATTCATGCTCCAGGAAGCAGATAAGCTTGGCTGCAGACAGTTTGTCACGCCTGCAGAT
GTGGTTTCAGGGAACCCTAAGCTAAACTTAGCCTTTGTAGCGAATCTTTTTAACACATACCCAT
GTCTCCACAAGCCTGACAACAATGACATTGATCTCAACTTACTGGAAGGAGAGAGCAAGGAAGA
GAGGACATTTCGGAACTGGATGAATTCACTGGGTGTCAACCCATACATCAATCACTTGTACAGT
GACCTCGCAGATGCCTTGGTGATCTTTCAGCTCTATGAGATGATCCGCGTGCCAGTCAACTGGA
ACCATGTCAACAAGCCTCCCTACCCTGCCCTTGGAGGGAACATGAAGAAGATTGAAAACTGCAA
CTACGCAGTTGAGCTCGGGAAGAACGAGGCCAAATTCTCTTTGGTTGGTATCGCCGGACAGGAC
TTAAATGAAGGGAATGCAACACTTACCCTGGCTCTGGTGTGGCAGTTGATGAGAAGATACACGC
TGAAAGTTCTGTCAGACCTGGGAGAAGGTGAAAAAGTCAGTGATGATATCATTATTAAATGGGT
CAATCAGACCCTTAAAAGTGCAAATAAAAGTACTTCTATTTCCAGCTTCAAGGATAAATCTATT
AGTACAAGCTTGCCTGTCTTAGATCTAATAGATGCCATTGCACCAAATGCAGTCCGTCCGGAAA
TGATCAAGAGAGAACACTTGACTGACGAAGACAAGCTGAACAATGCTAAATATGCCATTTCAGT
TGCTCGGAAGATCGGCGCCCGGATATACGCGCTGCCTGATGACCTCGTGGAAGTGAAGCCGAAG
ATGGTGATGACTGTGTTTGCCTGCTTAATGGGAAAGGGACTGAACAGACTGAAATAATGAACCA
TGTACTGTGACCTGTCACATTACACGCATCGAACGTCTCAGTTTACAGAATTTTGAAATGTAGT
GGGTATCAAATCAGAATATCTGTATGCTCCAAACAGTTCTGTGTCCAGTAATGAATAATATCTT
GTCCATACCAGTTAGAATTTGTCAATCTATTTTTTAGATAACACAATTACCTTAACAATCAACA
CCAATTCAGGAATGTTTTCCTCAAGCTGCTATTTCATAATTATTTTATTCCCTAAGAGTCTTAC
CAAAATAAGACTAATCATTCATTTTTCATGGCTCAAAAAAGACCTGTATAAAGTTTTGTCAGAT
CCTTCTATTAAATTTGTTTGGATTTTTTTGATGTGTTGTTTAATTTTGATTAAAAATGTACCTA
AAGTCGTATTCTAACTTTAATTTAATCCTTTTGTTTTTCCTCCTTAACTATGTAAAGCAATCTA
AAATTTTCTGTAAATTTCTATATCATATAAAAATTTAAAAGGATAAGTATCATTCGTCAACATT
AAACTTTTTTAATATGAGAACTAATTCTTGAATAACCCCCAAGGTTCCCTCTCTTGTATAAGCT
CTGGAAACATTTTACTTAAAGTTTGATTATAACTCCATTGCCTCTTTACGCGTCCTAGTTTGAT
AATATAGCTTTATCATCAACATCTAGCGTAATTTAATATGTTGGTAAGATGTTATATATATGTA
CTCCTCTAAGTCATCCGAGTTACCCACATTTTCTTAAATGGTATGTATTAAGTGGTCAGCCAAC
CATTAAGTATTTATTTTGCCCCCCACAATGTGTGTGACACTTTTCAGTTGTGGATATCTGATAT
GTGAAGATATGTTTTGCAGATATTAATTATGAATGTGAACACAGTTATTTTTCACCTAATTCCT
TTCAAATACTTTCAGCCAAACATTGGATAGAACATCCCAACCGACACTGATCCTATCCTGTTAG
CGTCACGTTACACTTCCTGGTTTTAGTCTATAGTGAAACCTACATAATTGGAATCTGCCCACCA
AATAAATGGTTTCAGTAGAAAGGTGTGTATAAAAACTAACGTCCGTCGTCGTCGTTTTTCATGG
TTTTCACAGCCCTGTGTAAACTGGAAACGTTTAAGGTCTGTGTTCCTCGGGAAGAGTTAAAGCT
TGTAGGCTCTTTTCCCAGCATCCTTAGCGGTAGAGAAATTCTGTTCTCCATAGTTGAAGCCCCA
AACAAGCTCCCCCCACCTTCCACTTTAGTGCCAGTGAGCAATACTGCTTTGCAACGGAAGTGCT
GTCACTTCTCTGTGTGAATGAGCGCCCACCTCCTCCTTGTCCACTGACCAACATACATCGGGAG
CAAGAGTGTCTGTGTGCTTAGGCTAGACTTTTTTAAATGAACTAACAGGTGGGATTCTGAAATA
TATTCTTCTACATGAAATTTCTTTGCCTTTTATATTTTGATGATTGTTTTCTTATGTGAAGATA
TAAGTATGCTTCTGCTCTTTTCCTGAGATGATTTAAGTCGCGCCTCTCTTGATTTTTTTCCACT
GTCATACTTACTAAAATCATCTGATTTACATGGAATTTAGCACTTTAAGGTGTTCTTTTTCTCA
TGAAGTATATTTAATAAAAATGCTGTGTATGTAG

hide sequence

RefSeq Acc Id:

XM_039081542 ⟹ XP_038937470

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	105,196,312 - 105,306,252 (-)	NCBI
mRatBN7.2	8	96,316,705 - 96,426,592 (-)	NCBI

RefSeq Acc Id:

XM_063265574 ⟹ XP_063121644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	105,196,312 - 105,264,488 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101648	(Get FASTA)	NCBI Sequence Viewer
	XP_006243636	(Get FASTA)	NCBI Sequence Viewer
	XP_038937470	(Get FASTA)	NCBI Sequence Viewer
	XP_063121644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68847	(Get FASTA)	NCBI Sequence Viewer
	EDL77510	(Get FASTA)	NCBI Sequence Viewer
	EDL77511	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013209
	ENSRNOP00000013209.7

RefSeq Acc Id:

NP_001101648 ⟸ NM_001108178

- UniProtKB:

B5DEY0 (UniProtKB/TrEMBL), F1LQQ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MINLSEPDTIDERAINKKKLTPFTVSENLNLALNSASAIGCTVVNIGAQDLKEGKPHLVLGLLW
QIIKVGLFADIEISRNEALIALLKEGEELEELMKLSPEELLLRWVNYHLTNAGWRTISNFSQDI
KDSKAYFHLLNQIAPKGDRDGGSAVTIDLSGFNEKNDLKRAGFMLQEADKLGCRQFVTPADVVS
GNPKLNLAFVANLFNTYPCLHKPDNNDIDLNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLA
DALVIFQLYEMIRVPVNWNHVNKPPYPALGGNMKKIENCNYAVELGKNEAKFSLVGIAGQDLNE
GNATLTLALVWQLMRRYTLKVLSDLGEGEKVSDDIIIKWVNQTLKSANKSTSISSFKDKSISTS
LPVLDLIDAIAPNAVRPEMIKREHLTDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVM
TVFACLMGKGLNRLK

hide sequence

RefSeq Acc Id:	XP_006243636 ⟸ XM_006243574
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2QC04 (UniProtKB/TrEMBL)
- Sequence:	show sequence MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILVVAD NNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSSISSEGTQHSYSEEEKVAF VNWINKALENDADCSHLLPMNPNDGSLFRSLADGILLCKMINLSEPDTIDERAINKKKLTPFTV SENLNLALNSASAIGCTVVNIGAQDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLKE GEELEELMKLSPEELLLRWVNYHLTNAGWRTISNFSQDIKDSKAYFHLLNQIAPKGDRDGGSAV TIDLSGFNEKNDLKRAGFMLQEADKLGCRQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPDN NDIDLNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWNHVNKPP YPALGGNMKKIENCNYAVELGKNEAKFSLVGIAGQDLNEGNATLTLALVWQLMRRYTLKVLSDL GEGEKVSDDIIIKWVNQTLKSANKSTSISSFKDKSISTSLPVLDLIDAIAPNAVRPEMIKREHL TDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRLK hide sequence

RefSeq Acc Id:

ENSRNOP00000013209 ⟸ ENSRNOT00000013209

RefSeq Acc Id:	XP_038937470 ⟸ XM_039081542
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2QC04 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121644 ⟸ XM_063265574
- Peptide Label:	isoform X1

Protein Domains

Calponin-homology (CH) EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2QC04-F1-model_v2	AlphaFold	A0A0G2QC04	1-630	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696188

Promoter ID:

EPDNEW_R6712

Type:

initiation region

Name:

Pls1_1

Description:

plastin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	103,608,975 - 103,609,035	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307142	AgrOrtholog
BioCyc Gene	G2FUF-29477	BioCyc
Ensembl Genes	ENSRNOG00000009945	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013209.8	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	Actinin_actin-bd_CS	UniProtKB/TrEMBL
	Calponin-like_dom_sf	UniProtKB/TrEMBL
	CH-domain	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Fimbrin/Plastin	UniProtKB/TrEMBL
KEGG Report	rno:315926	UniProtKB/TrEMBL
NCBI Gene	315926	ENTREZGENE
PANTHER	PTHR19961	UniProtKB/TrEMBL
	PTHR19961:SF27	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
	PF00307	UniProtKB/TrEMBL
PharmGKB	PLS1	RGD
PhenoGen	Pls1	PhenoGen
PROSITE	ACTININ_1	UniProtKB/TrEMBL
	ACTININ_2	UniProtKB/TrEMBL
	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	PS50021	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009945	RatGTEx
SMART	EFh	UniProtKB/TrEMBL
	SM00033	UniProtKB/TrEMBL
Superfamily-SCOP	Calponin-homology	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0G2QC04	ENTREZGENE, UniProtKB/TrEMBL
	B5DEY0	ENTREZGENE, UniProtKB/TrEMBL
	F1LQQ6	ENTREZGENE
UniProt Secondary	F1LQQ6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Pls1	plastin 1	Pls1	plastin 1 (I isoform)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pls1	plastin 1 (I isoform)	Pls1_predicted	plastin 1 (I isoform) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pls1_predicted	plastin 1 (I isoform) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations