Cdh7 (cadherin 7) - Rat Genome Database

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Gene: Cdh7 (cadherin 7) Rattus norvegicus
Analyze
Symbol: Cdh7
Name: cadherin 7
RGD ID: 1306856
Description: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH7 (cadherin 7); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cad7; cadherin 7, type 2; cadherin-7; Cadherin7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81327,186,223 - 27,336,076 (+)NCBIGRCr8
mRatBN7.21326,672,058 - 26,821,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1326,672,484 - 26,819,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1327,026,414 - 27,166,627 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01328,310,876 - 28,451,099 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01326,983,235 - 27,119,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01331,081,064 - 31,228,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1331,081,804 - 31,231,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01336,218,960 - 36,368,374 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41316,884,417 - 17,020,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11316,871,885 - 17,009,083 (+)NCBI
Celera1326,435,771 - 26,572,149 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18801203  


Genomics

Comparative Map Data
Cdh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81327,186,223 - 27,336,076 (+)NCBIGRCr8
mRatBN7.21326,672,058 - 26,821,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1326,672,484 - 26,819,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1327,026,414 - 27,166,627 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01328,310,876 - 28,451,099 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01326,983,235 - 27,119,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01331,081,064 - 31,228,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1331,081,804 - 31,231,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01336,218,960 - 36,368,374 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41316,884,417 - 17,020,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11316,871,885 - 17,009,083 (+)NCBI
Celera1326,435,771 - 26,572,149 (+)NCBICelera
Cytogenetic Map13q11NCBI
CDH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381865,750,252 - 65,890,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1865,750,252 - 65,890,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371863,417,488 - 63,557,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361861,568,468 - 61,699,155 (+)NCBINCBI36Build 36hg18NCBI36
Build 341861,568,467 - 61,699,155NCBI
Celera1860,138,894 - 60,269,263 (+)NCBICelera
Cytogenetic Map18q22.1NCBI
HuRef1860,120,344 - 60,250,758 (+)NCBIHuRef
CHM1_11863,413,070 - 63,543,109 (+)NCBICHM1_1
T2T-CHM13v2.01865,956,460 - 66,096,655 (+)NCBIT2T-CHM13v2.0
Cdh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391109,909,967 - 110,073,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1109,910,161 - 110,067,887 (+)EnsemblGRCm39 Ensembl
GRCm381109,982,237 - 110,145,272 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1109,982,431 - 110,140,157 (+)EnsemblGRCm38mm10GRCm38
MGSCv371111,880,314 - 112,035,578 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,811,284 - 111,966,548 (+)NCBIMGSCv36mm8
Celera1112,730,070 - 112,891,174 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.73NCBI
Cdh7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540249,444,814 - 49,562,803 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540249,444,814 - 49,568,653 (+)NCBIChiLan1.0ChiLan1.0
CDH7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21783,258,753 - 83,401,432 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11868,951,362 - 69,094,046 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01859,104,931 - 59,244,999 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11862,413,667 - 62,546,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1862,413,715 - 62,543,844 (+)Ensemblpanpan1.1panPan2
CDH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,699,505 - 11,824,489 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,706,673 - 11,824,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,724,197 - 12,849,596 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,551,512 - 11,676,795 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,558,649 - 11,677,951 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,581,912 - 11,707,059 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,525,142 - 11,649,944 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,768,853 - 11,894,341 (-)NCBIUU_Cfam_GSD_1.0
Cdh7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494424,927,755 - 25,054,446 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936497168,265 - 293,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1156,295,434 - 156,435,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11156,295,885 - 156,436,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21173,581,771 - 173,665,159 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDH7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11813,867,659 - 14,009,754 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1813,870,360 - 13,989,936 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606011,781,146 - 11,883,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479211,849,046 - 11,958,461 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479211,836,034 - 11,963,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdh7
1160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000041413
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 4 27 113 35 26 5 25 5 6 113 69 93 31 53 21

Sequence


Ensembl Acc Id: ENSRNOT00000041413   ⟹   ENSRNOP00000049491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1326,672,484 - 26,819,846 (+)Ensembl
Rnor_6.0 Ensembl1331,081,804 - 31,231,213 (+)Ensembl
RefSeq Acc Id: NM_001012737   ⟹   NP_001012755
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81327,197,582 - 27,334,344 (+)NCBI
mRatBN7.21326,683,081 - 26,819,846 (+)NCBI
Rnor_6.01331,092,405 - 31,228,088 (+)NCBI
Rnor_5.01336,218,960 - 36,368,374 (+)NCBI
RGSC_v3.41316,884,417 - 17,020,846 (+)RGD
Celera1326,435,771 - 26,572,149 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598763   ⟹   XP_017454252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81327,186,223 - 27,336,076 (+)NCBI
mRatBN7.21326,672,472 - 26,821,571 (+)NCBI
Rnor_6.01331,082,331 - 31,228,884 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598764   ⟹   XP_017454253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81327,186,241 - 27,334,966 (+)NCBI
mRatBN7.21326,672,058 - 26,821,571 (+)NCBI
Rnor_6.01331,081,374 - 31,228,884 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012755 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454252 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454253 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD90595 (Get FASTA)   NCBI Sequence Viewer  
  EDL91762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049491.2
GenBank Protein Q5DWV2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012755   ⟸   NM_001012737
- Peptide Label: precursor
- UniProtKB: G3V9J2 (UniProtKB/TrEMBL),   A6JSW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454253   ⟸   XM_017598764
- Peptide Label: isoform X1
- UniProtKB: Q5DWV2 (UniProtKB/Swiss-Prot),   G3V9J2 (UniProtKB/TrEMBL),   A6JSW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454252   ⟸   XM_017598763
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000049491   ⟸   ENSRNOT00000041413
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5DWV2-F1-model_v2 AlphaFold Q5DWV2 1-785 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306856 AgrOrtholog
BioCyc Gene G2FUF-18562 BioCyc
Ensembl Genes ENSRNOG00000032490 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041413.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29162 UniProtKB/Swiss-Prot
NCBI Gene 29162 ENTREZGENE
PANTHER CADHERIN-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdh7 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032490 RatGTEx
SMART SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JSW4 ENTREZGENE, UniProtKB/TrEMBL
  CADH7_RAT UniProtKB/Swiss-Prot
  G3V9J2 ENTREZGENE, UniProtKB/TrEMBL
  Q5DWV2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Cdh7  cadherin 7  Cdh7  cadherin 7, type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cdh7  cadherin 7, type 2  Cdh7_predicted  cadherin 7, type 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cdh7_predicted  cadherin 7, type 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED