Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HMBOX1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HMBOX1 mRNA | CTD | PMID:29097150 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMBOX1 mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HMBOX1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HMBOX1 mRNA | CTD | PMID:32109520 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMBOX1 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | bisphenol S results in decreased expression of HMBOX1 mRNA | CTD | PMID:27685785 | aflatoxin B1 | decreases methylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HMBOX1 gene | CTD | PMID:27153756 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of HMBOX1 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HMBOX1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to HMBOX1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | affects methylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HMBOX1 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HMBOX1 mRNA | CTD | PMID:30453624 | benzo[b]fluoranthene | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in decreased expression of HMBOX1 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HMBOX1 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of HMBOX1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HMBOX1 mRNA | CTD | PMID:29097150 | bisphenol F | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMBOX1 mRNA | CTD | PMID:28628672 | butanal | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of HMBOX1 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMBOX1 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMBOX1 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HMBOX1 gene] | CTD | PMID:28238834 | chrysene | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | chrysene results in decreased expression of HMBOX1 mRNA | CTD | PMID:26377693 | cisplatin | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of HMBOX1 mRNA | CTD | PMID:27594783 | copper atom | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HMBOX1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HMBOX1 mRNA | CTD | PMID:20971185 | crocidolite asbestos | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of HMBOX1 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HMBOX1 mRNA | CTD | PMID:20106945 more ... | dexamethasone | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMBOX1 mRNA | CTD | PMID:28628672 | disodium selenite | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of HMBOX1 mRNA | CTD | PMID:24383545 | doxorubicin | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HMBOX1 mRNA | CTD | PMID:29803840 | ethanol | increases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Ethanol results in increased expression of HMBOX1 mRNA | CTD | PMID:30319688 | FR900359 | increases phosphorylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of HMBOX1 protein | CTD | PMID:37730182 | fulvestrant | increases methylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of HMBOX1 gene | CTD | PMID:31601247 | geraniol | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | geraniol results in increased expression of HMBOX1 mRNA | CTD | PMID:27683099 | indometacin | multiple interactions | ISO | HMBOX1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMBOX1 mRNA | CTD | PMID:28628672 | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of HMBOX1 mRNA | CTD | PMID:28801915 | menadione | affects expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of HMBOX1 mRNA | CTD | PMID:20044591 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of HMBOX1 mRNA | CTD | PMID:28801915 | ozone | multiple interactions | ISO | Hmbox1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of HMBOX1 mRNA | CTD | PMID:34911549 | pentanal | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | pentanal results in decreased expression of HMBOX1 mRNA | CTD | PMID:26079696 | phenobarbital | affects expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of HMBOX1 mRNA | CTD | PMID:23091169 | silicon dioxide | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of HMBOX1 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HMBOX1 mRNA | CTD | PMID:28595984 and PMID:34032870 | sodium arsenite | affects expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of HMBOX1 mRNA | CTD | PMID:29319823 | temozolomide | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of HMBOX1 mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of HMBOX1 mRNA | CTD | PMID:17484886 | titanium dioxide | increases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of HMBOX1 mRNA | CTD | PMID:29264374 | titanium dioxide | increases methylation | ISO | HMBOX1 (Homo sapiens) | 6480464 | titanium dioxide results in increased methylation of HMBOX1 gene | CTD | PMID:34973136 | titanium dioxide | affects expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | titanium dioxide affects the expression of HMBOX1 mRNA | CTD | PMID:34973136 | tungsten | decreases expression | ISO | Hmbox1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of HMBOX1 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Urethane results in increased expression of HMBOX1 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HMBOX1 mRNA | CTD | PMID:23179753 | vorinostat | decreases expression | ISO | HMBOX1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of HMBOX1 mRNA | CTD | PMID:27188386 | |