Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cope | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of COPE mRNA | CTD | PMID:36331819 | Cope | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of COPE mRNA | CTD | PMID:22206623 | Cope | Rat | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | COPE (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to COPE protein | CTD | PMID:32991956 | Cope | Rat | 14-Deoxy-11,12-didehydroandrographolide | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | 14-deoxy-11 and 12-didehydroandrographolide results in decreased expression of COPE mRNA | CTD | PMID:22101062 | Cope | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Cope (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of COPE mRNA | CTD | PMID:17555576 | Cope | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPE mRNA | CTD | PMID:17942748 | Cope | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of COPE mRNA | CTD | PMID:32145629 | Cope | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Cope (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPE mRNA | CTD | PMID:17942748 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of COPE mRNA | CTD | PMID:33387578 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of COPE mRNA | CTD | PMID:34747641 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of COPE mRNA | CTD | PMID:32109520 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cope (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of COPE mRNA | CTD | PMID:21570461 | Cope | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of COPE mRNA | CTD | PMID:21296121 | Cope | Rat | 2,4,6-tribromophenol | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Cope | Rat | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of COPE mRNA | CTD | PMID:21346803 | Cope | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of COPE protein | CTD | PMID:31675489 | Cope | Rat | aconitine | increases expression | EXP | | 6480464 | Aconitine results in increased expression of COPE protein | CTD | PMID:33236894 | Cope | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of COPE mRNA | CTD | PMID:28959563 | Cope | Rat | aflatoxin B1 | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of COPE mRNA | CTD | PMID:27153756 | Cope | Rat | benzo[a]pyrene | increases expression | ISO | Cope (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of COPE mRNA | CTD | PMID:22228805 | Cope | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of COPE mRNA | CTD | PMID:26496021 | Cope | Rat | bisphenol A | increases expression | ISO | COPE (Homo sapiens) | 6480464 | bisphenol A results in increased expression of COPE protein | CTD | PMID:37567409 | Cope | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of COPE mRNA | CTD | PMID:34947998 | Cope | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of COPE mRNA | CTD | PMID:25181051 more ... | Cope | Rat | bisphenol F | increases expression | ISO | COPE (Homo sapiens) | 6480464 | bisphenol F results in increased expression of COPE protein | CTD | PMID:34186270 | Cope | Rat | bufalin | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | bufalin results in decreased expression of COPE protein | CTD | PMID:23091618 | Cope | Rat | butan-1-ol | multiple interactions | ISO | COPE (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of COPE mRNA | CTD | PMID:29432896 | Cope | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of COPE promoter | CTD | PMID:22457795 | Cope | Rat | cadmium dichloride | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of COPE mRNA | CTD | PMID:38568856 | Cope | Rat | caffeine | increases phosphorylation | ISO | COPE (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of COPE protein | CTD | PMID:35688186 | Cope | Rat | carbon nanotube | increases expression | ISO | Cope (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Cope | Rat | chlorpyrifos | increases expression | ISO | Cope (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of COPE mRNA | CTD | PMID:37019170 | Cope | Rat | chrysene | decreases expression | ISO | Cope (Mus musculus) | 6480464 | chrysene results in decreased expression of COPE mRNA | CTD | PMID:26377693 | Cope | Rat | clobetasol | increases expression | ISO | Cope (Mus musculus) | 6480464 | Clobetasol results in increased expression of COPE mRNA | CTD | PMID:27462272 | Cope | Rat | clofibrate | decreases expression | ISO | Cope (Mus musculus) | 6480464 | Clofibrate results in decreased expression of COPE mRNA | CTD | PMID:17585979 | Cope | Rat | cobalt dichloride | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of COPE mRNA and cobaltous chloride results in decreased expression of COPE protein | CTD | PMID:16622835 and PMID:19376846 | Cope | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of COPE mRNA | CTD | PMID:30556269 | Cope | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of COPE mRNA | CTD | PMID:30556269 | Cope | Rat | coumarin | increases phosphorylation | ISO | COPE (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of COPE protein | CTD | PMID:35688186 | Cope | Rat | crocidolite asbestos | increases expression | ISO | Cope (Mus musculus) | 6480464 | Asbestos and Crocidolite results in increased expression of COPE mRNA | CTD | PMID:29279043 | Cope | Rat | cyclosporin A | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of COPE mRNA | CTD | PMID:20106945 more ... | Cope | Rat | elemental selenium | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Selenium results in increased expression of COPE mRNA | CTD | PMID:19244175 | Cope | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of COPE mRNA | CTD | PMID:29391264 | Cope | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of COPE mRNA | CTD | PMID:23962444 | Cope | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of COPE mRNA | CTD | PMID:24136188 | Cope | Rat | folic acid | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of COPE mRNA | CTD | PMID:22206623 | Cope | Rat | FR900359 | increases phosphorylation | ISO | COPE (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of COPE protein | CTD | PMID:37730182 | Cope | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of COPE mRNA | CTD | PMID:24136188 | Cope | Rat | hydralazine | multiple interactions | ISO | COPE (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of COPE mRNA | CTD | PMID:17183730 | Cope | Rat | ivermectin | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of COPE protein | CTD | PMID:32959892 | Cope | Rat | maneb | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA | CTD | PMID:18386188 | Cope | Rat | methidathion | increases expression | ISO | Cope (Mus musculus) | 6480464 | methidathion results in increased expression of COPE mRNA | CTD | PMID:34813904 | Cope | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of COPE mRNA | CTD | PMID:24136188 | Cope | Rat | paclitaxel | affects response to substance | ISO | COPE (Homo sapiens) | 6480464 | COPE protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | Cope | Rat | paracetamol | affects expression | ISO | Cope (Mus musculus) | 6480464 | Acetaminophen affects the expression of COPE mRNA | CTD | PMID:17562736 | Cope | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of COPE mRNA | CTD | PMID:33387578 | Cope | Rat | paraquat | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA | CTD | PMID:18386188 | Cope | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Cope (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of COPE mRNA | CTD | PMID:36331819 | Cope | Rat | quercetin | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Quercetin results in increased expression of COPE mRNA | CTD | PMID:21632981 | Cope | Rat | resveratrol | multiple interactions | ISO | COPE (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of COPE mRNA | CTD | PMID:23557933 | Cope | Rat | selenium atom | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Selenium results in increased expression of COPE mRNA | CTD | PMID:19244175 | Cope | Rat | sodium arsenite | increases expression | ISO | COPE (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of COPE mRNA | CTD | PMID:38568856 | Cope | Rat | sodium arsenite | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of COPE protein | CTD | PMID:30528433 | Cope | Rat | sunitinib | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of COPE mRNA | CTD | PMID:31533062 | Cope | Rat | T-2 toxin | affects expression | EXP | | 6480464 | T-2 Toxin affects the expression of COPE protein | CTD | PMID:26141394 | Cope | Rat | tamoxifen | affects expression | ISO | Cope (Mus musculus) | 6480464 | Tamoxifen affects the expression of COPE mRNA | CTD | PMID:17555576 | Cope | Rat | tert-butyl hydroperoxide | decreases expression | ISO | COPE (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of COPE mRNA | CTD | PMID:15336504 | Cope | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of COPE mRNA | CTD | PMID:26496021 | Cope | Rat | testosterone | decreases expression | ISO | Cope (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of COPE mRNA | CTD | PMID:33848595 | Cope | Rat | tetrachloroethene | decreases expression | ISO | Cope (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of COPE mRNA | CTD | PMID:28973375 | Cope | Rat | tetrachloromethane | increases expression | ISO | Cope (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of COPE mRNA | CTD | PMID:31919559 | Cope | Rat | triphenyl phosphate | affects expression | ISO | COPE (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of COPE mRNA | CTD | PMID:37042841 | Cope | Rat | tunicamycin | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of COPE mRNA | CTD | PMID:29453283 | Cope | Rat | valproic acid | multiple interactions | ISO | COPE (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of COPE mRNA | CTD | PMID:17183730 | Cope | Rat | valproic acid | increases methylation | ISO | COPE (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of COPE gene | CTD | PMID:29154799 | Cope | Rat | vitamin E | increases expression | ISO | COPE (Homo sapiens) | 6480464 | Vitamin E results in increased expression of COPE mRNA | CTD | PMID:19244175 | |