Tm2d2 (TM2 domain containing 2) - Rat Genome Database

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Gene: Tm2d2 (TM2 domain containing 2) Rattus norvegicus
Analyze
Symbol: Tm2d2
Name: TM2 domain containing 2
RGD ID: 1306769
Description: Predicted to be located in membrane. Orthologous to human TM2D2 (TM2 domain containing 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2410018g23rik; BBP-like protein 1; LOC290833; RGD1306769; similar to RIKEN cDNA 2410018G23; TM2 domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Arunc2 Arunc1 Arunc4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21667,016,683 - 67,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,012,675 - 67,022,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,293,869 - 72,299,391 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01675,699,837 - 75,705,359 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01670,946,366 - 70,951,899 (-)NCBIRnor_WKY
Rnor_6.01671,804,368 - 71,809,891 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,804,350 - 71,809,925 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,453,135 - 71,458,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,440,489 - 71,446,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,440,754 - 71,446,277 (-)NCBI
Celera1664,921,244 - 64,926,766 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Tm2d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21667,016,683 - 67,022,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,012,675 - 67,022,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,293,869 - 72,299,391 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01675,699,837 - 75,705,359 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01670,946,366 - 70,951,899 (-)NCBIRnor_WKY
Rnor_6.01671,804,368 - 71,809,891 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,804,350 - 71,809,925 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,453,135 - 71,458,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,440,489 - 71,446,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,440,754 - 71,446,277 (-)NCBI
Celera1664,921,244 - 64,926,766 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
TM2D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,988,808 - 38,996,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl838,988,808 - 38,996,824 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,846,327 - 38,854,028 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,965,484 - 38,973,198 (-)NCBINCBI36Build 36hg18NCBI36
Celera837,797,825 - 37,805,586 (-)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,379,168 - 37,386,883 (-)NCBIHuRef
CHM1_1839,048,404 - 39,056,118 (-)NCBICHM1_1
T2T-CHM13v2.0839,265,950 - 39,273,651 (-)NCBIT2T-CHM13v2.0
Tm2d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,507,227 - 25,513,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,507,227 - 25,513,276 (+)EnsemblGRCm39 Ensembl
GRCm38825,017,211 - 25,023,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,017,211 - 25,023,260 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,127,683 - 26,133,732 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,482,825 - 26,488,804 (+)NCBIMGSCv36mm8
Celera826,484,819 - 26,490,229 (+)NCBICelera
Cytogenetic Map8A2NCBI
Tm2d2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,537,919 - 14,545,823 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,537,902 - 14,545,147 (-)NCBIChiLan1.0ChiLan1.0
TM2D2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1835,466,949 - 35,472,985 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl835,466,949 - 35,472,985 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0838,290,204 - 38,297,903 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TM2D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11626,551,563 - 26,557,554 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1626,551,628 - 26,556,285 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,073,125 - 27,079,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01628,383,184 - 28,389,618 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,383,188 - 28,389,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11626,676,903 - 26,683,328 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,253,614 - 27,260,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,291,910 - 27,298,338 (+)NCBIUU_Cfam_GSD_1.0
Tm2d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,159,956 - 49,163,023 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367102,297,247 - 2,301,232 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367102,298,233 - 2,301,239 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TM2D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,601,616 - 47,611,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,601,940 - 47,611,802 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,674,879 - 54,684,745 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TM2D2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,011,616 - 37,017,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,009,511 - 37,017,474 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660524,962,725 - 4,969,314 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tm2d2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247804,612,124 - 4,618,211 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247804,612,830 - 4,618,444 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tm2d2
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:419
Count of miRNA genes:214
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000022425
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH127392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21667,016,882 - 67,017,063 (+)MAPPERmRatBN7.2
Rnor_6.01671,804,568 - 71,804,748NCBIRnor6.0
Rnor_5.01671,453,335 - 71,453,515UniSTSRnor5.0
RGSC_v3.41671,440,689 - 71,440,869UniSTSRGSC3.4
Celera1664,921,444 - 64,921,624UniSTS
RH 3.4 Map16633.1UniSTS
Cytogenetic Map16q12.4UniSTS
RH136732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21667,022,996 - 67,023,132 (+)MAPPERmRatBN7.2
Rnor_6.01671,810,682 - 71,810,817NCBIRnor6.0
Rnor_5.01671,459,449 - 71,459,584UniSTSRnor5.0
RGSC_v3.41671,446,803 - 71,446,938UniSTSRGSC3.4
Celera1664,927,557 - 64,927,692UniSTS
RH 3.4 Map16624.5UniSTS
Cytogenetic Map16q12.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022425   ⟹   ENSRNOP00000022425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,016,683 - 67,022,226 (-)Ensembl
Rnor_6.0 Ensembl1671,804,350 - 71,809,925 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112655   ⟹   ENSRNOP00000094884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,012,675 - 67,022,184 (-)Ensembl
RefSeq Acc Id: NM_001017444   ⟹   NP_001017444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21667,016,683 - 67,022,206 (-)NCBI
Rnor_6.01671,804,368 - 71,809,891 (-)NCBI
Rnor_5.01671,453,135 - 71,458,658 (-)NCBI
RGSC_v3.41671,440,489 - 71,446,012 (-)RGD
Celera1664,921,244 - 64,926,766 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001017444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH93382 (Get FASTA)   NCBI Sequence Viewer  
  EDM09045 (Get FASTA)   NCBI Sequence Viewer  
  EDM09046 (Get FASTA)   NCBI Sequence Viewer  
  Q566R2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001017444   ⟸   NM_001017444
- Peptide Label: precursor
- UniProtKB: Q566R2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022425   ⟸   ENSRNOT00000022425
RefSeq Acc Id: ENSRNOP00000094884   ⟸   ENSRNOT00000112655

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q566R2-F1-model_v2 AlphaFold Q566R2 1-213 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700173
Promoter ID:EPDNEW_R10697
Type:multiple initiation site
Name:Tm2d2_1
Description:TM2 domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,809,890 - 71,809,950EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306769 AgrOrtholog
BioCyc Gene G2FUF-10952 BioCyc
Ensembl Genes ENSRNOG00000016559 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022425.5 UniProtKB/TrEMBL
  ENSRNOP00000094884 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022425.7 UniProtKB/TrEMBL
  ENSRNOT00000112655 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7389050 IMAGE-MGC_LOAD
InterPro TM2 UniProtKB/Swiss-Prot
KEGG Report rno:290833 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112677 IMAGE-MGC_LOAD
NCBI Gene 290833 ENTREZGENE
Pfam TM2 UniProtKB/Swiss-Prot
PhenoGen Tm2d2 PhenoGen
UniProt A0A8L2QCW5_RAT UniProtKB/TrEMBL
  Q566R2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tm2d2  TM2 domain containing 2  RGD1306769  similar to RIKEN cDNA 2410018G23  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1306769  similar to RIKEN cDNA 2410018G23  RGD1306769_predicted  similar to RIKEN cDNA 2410018G23 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306769_predicted  similar to RIKEN cDNA 2410018G23 (predicted)  LOC290833_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290833_predicted  similar to RIKEN cDNA 2410018G23 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL