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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TM2D2 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | decreases expression | ISO | RGD:1552483 | 6480464 | vinylidene chloride results in decreased expression of TM2D2 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1552483 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TM2D2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1552483 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of TM2D2 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1552483 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TM2D2 mRNA | CTD | PMID:18796159, PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TM2D2 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552483 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TM2D2 mRNA | CTD | PMID:21570461, PMID:24680724 | acrylamide | increases expression | ISO | RGD:1602456 | 6480464 | Acrylamide results in increased expression of TM2D2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | RGD:1602456 | 6480464 | Aflatoxin B1 results in decreased methylation of TM2D2 gene | CTD | PMID:27153756 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of TM2D2 mRNA | CTD | PMID:30779732 | antimycin A | decreases expression | ISO | RGD:1602456 | 6480464 | Antimycin A results in decreased expression of TM2D2 mRNA | CTD | PMID:33512557 | aristolochic acid A | decreases expression | ISO | RGD:1602456 | 6480464 | aristolochic acid I results in decreased expression of TM2D2 mRNA | CTD | PMID:33212167 | benzene | increases expression | ISO | RGD:1602456 | 6480464 | Benzene results in increased expression of TM2D2 mRNA | CTD | PMID:19162166 | benzo[a]pyrene | increases expression | ISO | RGD:1552483 | 6480464 | Benzo(a)pyrene results in increased expression of TM2D2 mRNA | CTD | PMID:14625279, PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | RGD:1602456 | 6480464 | Benzo(a)pyrene results in increased methylation of TM2D2 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | RGD:1552483 | 6480464 | [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TM2D2 mRNA] | CTD | PMID:14625279 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of TM2D2 mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | ISO | RGD:1552483 | 6480464 | bisphenol A results in increased expression of TM2D2 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | ISO | RGD:1602456 | 6480464 | bisphenol A results in decreased expression of TM2D2 mRNA | CTD | PMID:29275510 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of TM2D2 gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TM2D2 mRNA | CTD | PMID:25181051 | bortezomib | increases expression | ISO | RGD:1602456 | 6480464 | Bortezomib results in increased expression of TM2D2 mRNA | CTD | PMID:20977926 | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of TM2D2 mRNA | CTD | PMID:24136188 | chrysene | decreases expression | ISO | RGD:1552483 | 6480464 | chrysene results in decreased expression of TM2D2 mRNA | CTD | PMID:26377693 | cisplatin | increases expression | ISO | RGD:1602456 | 6480464 | Cisplatin results in increased expression of TM2D2 mRNA | CTD | PMID:19561079 | clobetasol | increases expression | ISO | RGD:1552483 | 6480464 | Clobetasol results in increased expression of TM2D2 mRNA | CTD | PMID:27462272 | clofibrate | multiple interactions | ISO | RGD:1552483 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of TM2D2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TM2D2 mRNA] | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | RGD:1552483 | 6480464 | Clofibrate results in decreased expression of TM2D2 mRNA | CTD | PMID:17585979, PMID:23811191 | copper(II) sulfate | affects expression | ISO | RGD:1602456 | 6480464 | Copper Sulfate affects the expression of TM2D2 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1602456 | 6480464 | Cyclosporine results in decreased expression of TM2D2 mRNA | CTD | PMID:25562108 | deguelin | decreases expression | ISO | RGD:1602456 | 6480464 | deguelin results in decreased expression of TM2D2 mRNA | CTD | PMID:33512557 | dicrotophos | decreases expression | ISO | RGD:1602456 | 6480464 | dicrotophos results in decreased expression of TM2D2 mRNA | CTD | PMID:28302478 | epoxiconazole | affects expression | ISO | RGD:1552483 | 6480464 | epoxiconazole affects the expression of TM2D2 mRNA | CTD | PMID:35436446 | fenthion | decreases expression | ISO | RGD:1552483 | 6480464 | Fenthion results in decreased expression of TM2D2 mRNA | CTD | PMID:34813904 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of TM2D2 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of TM2D2 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | RGD:1552483 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TM2D2 mRNA | CTD | PMID:22206623 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of TM2D2 mRNA | CTD | PMID:24136188 | paracetamol | multiple interactions | ISO | RGD:1552483 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of TM2D2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TM2D2 mRNA] | CTD | PMID:17585979 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TM2D2 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RGD:1602456 | 6480464 | Acetaminophen results in increased expression of TM2D2 mRNA | CTD | PMID:22230336 | paracetamol | affects expression | ISO | RGD:1552483 | 6480464 | Acetaminophen affects the expression of TM2D2 mRNA | CTD | PMID:17562736 | pirinixic acid | multiple interactions | ISO | RGD:1552483 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TM2D2 mRNA | CTD | PMID:19710929 | potassium chromate | multiple interactions | ISO | RGD:1552483 | 6480464 | [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TM2D2 mRNA] | CTD | PMID:14625279 | potassium dichromate | multiple interactions | ISO | RGD:1552483 | 6480464 | [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TM2D2 mRNA] | CTD | PMID:14625279 | sunitinib | decreases expression | ISO | RGD:1602456 | 6480464 | Sunitinib results in decreased expression of TM2D2 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of TM2D2 mRNA | CTD | PMID:26496021 | tetrachloromethane | affects expression | ISO | RGD:1552483 | 6480464 | Carbon Tetrachloride affects the expression of TM2D2 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | ISO | RGD:1552483 | 6480464 | Carbon Tetrachloride results in decreased expression of TM2D2 mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TM2D2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TM2D2 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TM2D2 mRNA | CTD | PMID:34492290 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of TM2D2 gene | CTD | PMID:27618143 | urethane | increases expression | ISO | RGD:1602456 | 6480464 | Urethane results in increased expression of TM2D2 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | RGD:1552483 | 6480464 | Valproic Acid results in increased expression of TM2D2 mRNA | CTD | PMID:20546886, PMID:21427059 | valproic acid | increases expression | ISO | RGD:1602456 | 6480464 | Valproic Acid results in increased expression of TM2D2 mRNA | CTD | PMID:23179753, PMID:29154799 | |