Lcn8 (lipocalin 8) - Rat Genome Database

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Gene: Lcn8 (lipocalin 8) Rattus norvegicus
Analyze
Symbol: Lcn8
Name: lipocalin 8
RGD ID: 1306747
Description: Predicted to enable small molecule binding activity. Predicted to act upstream of or within response to hormone. Predicted to be located in extracellular region. Orthologous to human LCN8 (lipocalin 8); INTERACTS WITH 3,4-methylenedioxymethamphetamine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: epididymal 17 kDa protein; epididymal 17 kDa protein precursor; epididymal-specific lipocalin-8; LOC366008; RGD1306747; similar to lipocalin precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,467,934 - 8,473,691 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,467,934 - 8,470,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,573,170 - 11,576,154 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,159,394 - 20,162,378 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,349,246 - 18,352,230 (+)NCBIRnor_WKY
Rnor_6.032,871,890 - 2,875,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,872,031 - 2,875,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,853,444 - 2,856,428 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,820,216 - 3,823,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,820,237 - 3,822,481 (+)NCBI
Celera33,292,835 - 3,295,819 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11181548  


Genomics

Comparative Map Data
Lcn8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,467,934 - 8,473,691 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,467,934 - 8,470,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,573,170 - 11,576,154 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0320,159,394 - 20,162,378 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,349,246 - 18,352,230 (+)NCBIRnor_WKY
Rnor_6.032,871,890 - 2,875,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,872,031 - 2,875,015 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,853,444 - 2,856,428 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,820,216 - 3,823,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,820,237 - 3,822,481 (+)NCBI
Celera33,292,835 - 3,295,819 (+)NCBICelera
Cytogenetic Map3p13NCBI
LCN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,754,386 - 136,758,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9136,754,386 - 136,758,543 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,648,838 - 139,652,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,768,661 - 138,772,552 (-)NCBINCBI36Build 36hg18NCBI36
Celera9110,161,959 - 110,165,851 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,107,983 - 109,111,935 (-)NCBIHuRef
CHM1_19139,797,366 - 139,801,258 (-)NCBICHM1_1
T2T-CHM13v2.09148,987,564 - 148,991,721 (-)NCBIT2T-CHM13v2.0
Lcn8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,543,130 - 25,546,229 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,543,132 - 25,546,229 (+)EnsemblGRCm39 Ensembl
GRCm38225,653,118 - 25,656,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,653,120 - 25,656,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,508,638 - 25,511,737 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,475,127 - 25,478,226 (+)NCBIMGSCv36mm8
Celera225,381,431 - 25,384,530 (+)NCBICelera
Cytogenetic Map2A3NCBI
Lcn8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,877,501 - 4,879,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,877,845 - 4,879,978 (-)NCBIChiLan1.0ChiLan1.0
LCN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19136,782,390 - 136,787,292 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,783,245 - 136,787,178 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09107,811,520 - 107,817,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LCN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,789,948 - 48,796,002 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,769,526 - 48,794,188 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,003,406 - 48,009,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,667,935 - 49,674,144 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,669,396 - 49,672,318 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,444,078 - 48,450,287 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,742,733 - 48,748,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,789,748 - 48,795,960 (+)NCBIUU_Cfam_GSD_1.0
Lcn8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,240,745 - 202,243,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,131,292 - 1,133,597 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366691,131,292 - 1,134,313 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,434,872 - 1,439,861 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,435,151 - 1,438,604 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,833,411 - 3,836,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lcn8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247601,052,765 - 1,055,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lcn8
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:79
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000023062
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 10 4 2
Below cutoff 2 4 19 13 6 13 1 1 21 9 14 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023062   ⟹   ENSRNOP00000023062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,467,934 - 8,470,918 (+)Ensembl
Rnor_6.0 Ensembl32,872,031 - 2,875,015 (+)Ensembl
RefSeq Acc Id: NM_001128183   ⟹   NP_001121655
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,467,934 - 8,470,918 (+)NCBI
Rnor_6.032,872,031 - 2,875,015 (+)NCBI
Rnor_5.032,853,444 - 2,856,428 (+)NCBI
RGSC_v3.433,820,216 - 3,823,200 (+)RGD
Celera33,292,835 - 3,295,819 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233632   ⟹   XP_006233694
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,467,956 - 8,473,691 (+)NCBI
Rnor_6.032,871,890 - 2,875,682 (+)NCBI
Rnor_5.032,853,444 - 2,856,428 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001121655 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABG24234 (Get FASTA)   NCBI Sequence Viewer  
  EDL93551 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001121655   ⟸   NM_001128183
- Peptide Label: precursor
- UniProtKB: B3EY82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233694   ⟸   XM_006233632
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000023062   ⟸   ENSRNOT00000023062
Protein Domains
Lipocln_cytosolic_FA-bd_dom

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B3EY82-F1-model_v2 AlphaFold B3EY82 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691889
Promoter ID:EPDNEW_R2413
Type:single initiation site
Name:Lcn8_1
Description:lipocalin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,872,032 - 2,872,092EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306747 AgrOrtholog
BioCyc Gene G2FUF-50431 BioCyc
Ensembl Genes ENSRNOG00000017161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023062 ENTREZGENE
  ENSRNOP00000023062.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023062 ENTREZGENE
  ENSRNOT00000023062.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocln_cytosolic_FA_bd UniProtKB/TrEMBL
KEGG Report rno:366008 UniProtKB/TrEMBL
NCBI Gene 366008 ENTREZGENE
PANTHER PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Lcn8 PhenoGen
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt B3EY82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lcn8  lipocalin 8   Lcn8_predicted  lipocalin 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Lcn8_predicted  lipocalin 8 (predicted)  RGD1306747_predicted  similar to lipocalin precursor; epididymal 17 kDa protein precursor (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1306747_predicted  similar to lipocalin precursor; epididymal 17 kDa protein precursor (predicted)  LOC366008_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366008_predicted  similar to lipocalin precursor; epididymal 17 kDa protein precursor (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL