Brdt (bromodomain testis associated)

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Gene: Brdt (bromodomain testis associated) Rattus norvegicus

Analyze

Symbol:

Brdt

Name:

bromodomain testis associated (Ensembl:bromodomain, testis-specific)

RGD ID:

1306678

Description:

Predicted to enable histone reader activity and lysine-acetylated histone binding activity. Involved in chromatin remodeling and spermatogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated); PARTICIPATES IN histone modification pathway; INTERACTS WITH allethrin; bisphenol A; cyhalothrin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

bromodomain testis-specific protein; bromodomain, testis-specific; LOC305123

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BRDT (bromodomain testis associated)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Brdt (bromodomain, testis-specific)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Brdt (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BRDT (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BRDT (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Brdt (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BRDT (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BRDT (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Brdt (bromodomain testis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BRDT (bromodomain testis associated)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Brdt (bromodomain, testis-specific)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	brdt (bromodomain, testis-specific)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	BDF1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bet-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fs(1)h	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BDF2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bet-2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	brdt	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	2,421,094 - 2,445,842 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	2,387,796 - 2,445,842 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	2,269,407 - 2,325,496 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,571,032 - 3,627,115 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	2,264,722 - 2,320,671 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	3,437,876 - 3,462,613 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	3,405,995 - 3,462,629 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	3,441,088 - 3,465,798 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,982,760 - 3,007,464 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,982,759 - 3,007,464 (-)	NCBI
Celera	14	2,437,605 - 2,462,270 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

azoospermia (ISO)

genetic disease (ISO)

oligospermia (ISO)

primary ovarian insufficiency (ISO)

spermatogenic failure 21 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

allethrin (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

diclofenac (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

inulin (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quercetin (ISO)

thioacetamide (EXP)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IBA,IDA,IEA,ISO)

male meiosis I (IEA,ISO,ISS)

male meiotic nuclear division (ISO,ISS)

mRNA processing (IEA)

positive regulation of transcription involved in meiotic cell cycle (IEA,ISO,ISS)

regulation of DNA-templated transcription (IBA,ISO)

regulation of RNA splicing (IEA,ISO,ISS)

RNA splicing (IEA)

sperm DNA condensation (IEA,ISO,ISS)

spermatogenesis (IEP,ISO)

Cellular Component

chromatin (IBA)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

histone binding (ISO)

histone reader activity (IEA,ISO,ISS)

lysine-acetylated histone binding (IBA,IEA,ISO,ISS)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of BET genes in testis of men with different spermatogenic impairments.	Barda S, etal., Fertil Steril. 2012 Jan;97(1):46-52.e5. doi: 10.1016/j.fertnstert.2011.10.010. Epub 2011 Oct 28.
2.	Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis.	Dhar S, etal., J Biol Chem. 2012 Feb 24;287(9):6387-405. doi: 10.1074/jbc.M111.288167. Epub 2012 Jan 3.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Association study of single-nucleotide polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with male infertility.	Plaseski T, etal., J Androl. 2012 Jul-Aug;33(4):675-83. doi: 10.2164/jandrol.111.013995. Epub 2011 Oct 20.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	The bromodomain: From epigenome reader to druggable target.	Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12861021	PMID:17728347	PMID:19794495	PMID:22464331	PMID:22570411	PMID:22922464	PMID:28199965

Genomics

Comparative Map Data

Brdt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	2,421,094 - 2,445,842 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	2,387,796 - 2,445,842 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	2,269,407 - 2,325,496 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,571,032 - 3,627,115 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	2,264,722 - 2,320,671 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	3,437,876 - 3,462,613 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	3,405,995 - 3,462,629 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	3,441,088 - 3,465,798 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,982,760 - 3,007,464 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,982,759 - 3,007,464 (-)	NCBI
Celera	14	2,437,605 - 2,462,270 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

BRDT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	91,949,371 - 92,014,428 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	91,949,343 - 92,014,426 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	92,414,928 - 92,479,985 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	92,187,720 - 92,252,573 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	92,127,152 - 92,192,004	NCBI
Celera	1	90,661,426 - 90,726,420 (+)	NCBI		Celera
Cytogenetic Map	1	p22.1	NCBI
HuRef	1	90,535,222 - 90,600,191 (+)	NCBI		HuRef
CHM1_1	1	92,529,832 - 92,594,805 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	91,794,237 - 91,859,235 (+)	NCBI		T2T-CHM13v2.0

Brdt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	107,478,982 - 107,534,927 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	107,479,025 - 107,534,924 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	107,331,116 - 107,387,061 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	107,331,159 - 107,387,058 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	107,760,213 - 107,816,077 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	107,571,461 - 107,625,997 (+)	NCBI		MGSCv36	mm8
Celera	5	104,443,624 - 104,500,438 (+)	NCBI		Celera
Cytogenetic Map	5	E5	NCBI

Brdt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	2,431,192 - 2,494,906 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	2,434,146 - 2,498,523 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRDT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	134,159,217 - 134,233,737 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	94,603,937 - 94,668,852 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	93,348,994 - 93,413,343 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	93,348,994 - 93,413,343 (+)	Ensembl	panpan1.1		panPan2

BRDT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	56,918,939 - 56,977,355 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	56,919,195 - 56,965,638 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	59,625,009 - 59,683,419 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	57,301,471 - 57,359,637 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	57,301,727 - 57,347,925 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	56,978,517 - 57,036,839 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	56,954,886 - 57,013,022 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	57,417,418 - 57,475,552 (-)	NCBI		UU_Cfam_GSD_1.0

Brdt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	101,843,528 - 101,906,986 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936537	7,040,993 - 7,104,245 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRDT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	125,004,494 - 125,060,392 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	125,004,897 - 125,062,208 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	136,603,415 - 136,604,320 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRDT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	41,229,493 - 41,293,899 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	41,229,643 - 41,280,341 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	76,698,619 - 76,761,937 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brdt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	5,727,939 - 5,798,809 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	5,730,805 - 5,798,731 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Brdt
110 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	183
Count of miRNA genes:	120
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000061538
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											11
Low		20	49	39	9	39	2	2	64	35	30	11	2
Below cutoff	3	23	8	2	10	2	6	8	10				6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001402393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000061538 ⟹ ENSRNOP00000058256

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	2,387,796 - 2,445,842 (-)	Ensembl
Rnor_6.0 Ensembl	14	3,405,995 - 3,462,629 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080901 ⟹ ENSRNOP00000072964

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	3,406,034 - 3,446,611 (-)	Ensembl

RefSeq Acc Id:

NM_001012031 ⟹ NP_001012031

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	2,421,094 - 2,445,842 (-)	NCBI
Rnor_6.0	14	3,437,876 - 3,462,613 (-)	NCBI
Rnor_5.0	14	3,441,088 - 3,465,798 (-)	NCBI
RGSC_v3.4	14	2,982,760 - 3,007,464 (-)	RGD
Celera	14	2,437,605 - 2,462,270 (-)	NCBI

Sequence:

show sequence

GCTGGCTGCTGACAGCCGCCATCCGGGCGAGAGCTGGCGGCCACCGGTGGAGAGCCGGGAGCGA
GGGCCCTGCACTGCTTCATCTAGTGCAAACGGAGAGGGTGATTGGATAAGGTCCCTTCCTAAGA
GGTACTACCATTGCTACAGAGGCTCGGCCCCGGGGCCGCCCCTGGCGGCTCTTTGGGAATTTGT
AGACTTCCTGCTAAGGCCTCAATTTGTATTTTTGAAGAACAGAAAGAAATTCTGTGAAGTGTTG
AAACCATTTAAACCATCTAAGACCAAGACATACCTACTGAAACAATGCACAGTATTTGTGTAAA
AAAGGACATATTCTCGTAGACACCTTGAAGATACCAGGATCTGAAGTAGTTGAGAATGTCTCTG
CCAAGTCGACAAATGGCTATTGTTAACCCCCCTCCACCAGAGTACATAAATGCTAAGAAAACTG
GGCGGTTGACCAACCAGCTGCAGTTCCTGCAGAGAGTCGTCCTGAAGGCGCTGTGGAAACACAG
TTTCTCCTGGCCGTTTCAACAGCCTGTGGATGCCGCGAAGCTCAAGCTGCCTGACTATTACACC
ATCATAGAGACGCCAATGGATTTAAGTACAATTAAGAAGCGGCTGGAAAACAGGTACTACGAGA
AGGCTTCCGAATGCGTGGGAGACTTCAACACGATGTTCTCAAACTGCTACTTATACAACAAGCC
TGGAGATGACATTGTGGTTATGGCCCAAGCTCTGGAGAAGTTATTTATGCAGAAGCTGTCTCAG
ATGCCACAGGAAGAGCAGATTGTGGGTGGCAAGGAGAGAATGAAGAAAGATATCCAACAAAAGA
CAGCCGTTTCCTCTGCTAAGGAACAAACTCCCTCCAAATCGGCAGAAAATGTGTTTAAGCGACA
AGAAATTCCTGCTGGGTTTCCTGATGTCTGTCTCTCTCCCTTAAACATGGCACAAGAGGCTCCC
CCGACCTGCGACTCACAGACTGTGGTCCAAATTACAAAGGGTGTGAAGAGGAGGGCGGACACAA
CAACTCCTACCACTTCCTCAGCTAAAGCAAGTAGTGAATCCCCTCCGCCACTGAGAGAAGCGAA
GCCGGCGAATGCGCCAGTGAAGGAAAACACAGTGAAGAGCGTCCTGCCAGACTCTCAGCAGCAA
CACAGGGTTTTAAAAACGGTCAAAGTAACGGAGCAGTTGAAGCACTGCAGCGAGATTCTTAAAG
AAATGCTTGCCAAGAAGCATCTGCCGTACGCATGGCCCTTCTACAACCCTGTGGACGTGGATGC
TTTGGGACTCCACAACTACTATGACATTGTCAAAAACCCCATGGATCTTGGAACGATCAAGGTA
AATACTGCCTGAGTGGGAAGAGCTTGCTTTCCTTGTCTTGATTGTAAAAGTGTCCCATCATTGC
AAAGAAATCGGTCCAATGTCCAGGAAACTGAAGACAATTACATCAGAGTACTAACACTGAAGAG
GACATTGGGACGCTTTAAATACATCTTGCTTTCCTGTAAACACAGCCATCTCACGAGCTAGTGG
AGATTGAACTAGGGCCCTCAGTAATCTTACACAGCATCTCCTGGCCCTGGCTCTCTTTAAAGCA
TGGCTTTGTTTCATTATTTTTATTAATATAGTAAAGTTTGTTAACTTGCTACTAAAAAAAAAAA
AAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001012031	(Get FASTA)	NCBI Sequence Viewer
	NP_001389322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78999	(Get FASTA)	NCBI Sequence Viewer
	AAI58631	(Get FASTA)	NCBI Sequence Viewer
	D4A7T3	(Get FASTA)	NCBI Sequence Viewer
	EDL83966	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012031 ⟸ NM_001012031

- UniProtKB:

Q6AYL3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPD
YYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQK
LSQMPQEEQIVGGKERMKKDIQQKTAVSSAKEQTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQ
EAPPTCDSQTVVQITKGVKRRADTTTPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDS
QQQHRVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGT
IKVNTA

hide sequence

RefSeq Acc Id:

ENSRNOP00000058256 ⟸ ENSRNOT00000061538

RefSeq Acc Id:

ENSRNOP00000072964 ⟸ ENSRNOT00000080901

Protein Domains

Bromo NET

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7T3-F1-model_v2	AlphaFold	D4A7T3	1-952	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699177

Promoter ID:

EPDNEW_R9686

Type:

initiation region

Name:

Brdt_1

Description:

Bromodomain testis-specific protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	3,462,626 - 3,462,686	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306678	AgrOrtholog
BioCyc Gene	G2FUF-16610	BioCyc
Ensembl Genes	ENSRNOG00000002073	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000058256.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000061538.4	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.220	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.920.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7456383	IMAGE-MGC_LOAD
InterPro	BRD4_CDT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromo_Brdt_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromo_Brdt_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromodomain-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromodomain_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NET_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NET_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:305123	UniProtKB/TrEMBL
MGC_CLONE	MGC:187542	IMAGE-MGC_LOAD
NCBI Gene	305123	ENTREZGENE
PANTHER	BROMODOMAIN TESTIS-SPECIFIC PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BET	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BRD4_CDT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bromodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Brdt	PhenoGen
PRINTS	BROMODOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BROMODOMAIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BROMODOMAIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NET	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BROMO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47370	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	BRDT_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	F7F8G2	ENTREZGENE, UniProtKB/TrEMBL
	Q6AYL3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Brdt	bromodomain testis associated	Brdt	bromodomain, testis-specific	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Brdt	bromodomain, testis-specific	Brdt_predicted	bromodomain, testis-specific (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Brdt_predicted	bromodomain, testis-specific (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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