Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tle2 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TLE2 mRNA] | CTD | PMID:31150632 | Tle2 | Rat | 1,1-dichloroethene | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of TLE2 mRNA | CTD | PMID:26682919 | Tle2 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of TLE2 mRNA | CTD | PMID:17555576 | Tle2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of TLE2 mRNA | CTD | PMID:35192832 | Tle2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | TLE2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TLE2 mRNA | CTD | PMID:22298810 | Tle2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TLE2 mRNA | CTD | PMID:33387578 | Tle2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TLE2 mRNA | CTD | PMID:21570461 | Tle2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TLE2 mRNA | CTD | PMID:22298810 | Tle2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Tle2 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of TLE2 mRNA | CTD | PMID:25172293 | Tle2 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Tle2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of TLE2 mRNA | CTD | PMID:26251327 | Tle2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TLE2 mRNA | CTD | PMID:28628672 | Tle2 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Tle2 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of TLE2 exon | CTD | PMID:33297965 | Tle2 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of TLE2 mRNA | CTD | PMID:31881176 | Tle2 | Rat | aflatoxin B1 | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of TLE2 mRNA | CTD | PMID:27153756 | Tle2 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | TLE2 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of TLE2 intron | CTD | PMID:30157460 | Tle2 | Rat | all-trans-retinoic acid | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of TLE2 mRNA | CTD | PMID:21934132 | Tle2 | Rat | arsane | affects methylation | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of TLE2 gene | CTD | PMID:25304211 | Tle2 | Rat | arsenic atom | affects methylation | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of TLE2 gene | CTD | PMID:25304211 | Tle2 | Rat | arsenous acid | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of TLE2 mRNA | CTD | PMID:20458559 | Tle2 | Rat | arsenous acid | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of TLE2 mRNA | CTD | PMID:26705709 | Tle2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Tle2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of TLE2 mRNA] | CTD | PMID:22228805 | Tle2 | Rat | benzo[a]pyrene | affects methylation | ISO | TLE2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TLE2 promoter | CTD | PMID:27901495 | Tle2 | Rat | benzo[a]pyrene | increases expression | ISO | Tle2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TLE2 mRNA | CTD | PMID:22228805 | Tle2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of TLE2 mRNA | CTD | PMID:28085963 | Tle2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TLE2 mRNA | CTD | PMID:25181051 more ... | Tle2 | Rat | bisphenol A | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of TLE2 mRNA | CTD | PMID:32156529 | Tle2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TLE2 mRNA | CTD | PMID:35192832 | Tle2 | Rat | bisphenol A | decreases methylation | ISO | TLE2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of TLE2 gene | CTD | PMID:31601247 | Tle2 | Rat | bisphenol A | increases expression | ISO | Tle2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of TLE2 mRNA | CTD | PMID:34585602 | Tle2 | Rat | bisphenol F | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of TLE2 mRNA | CTD | PMID:38685157 | Tle2 | Rat | cadmium atom | multiple interactions | ISO | Tle2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TLE2 mRNA | CTD | PMID:37325564 | Tle2 | Rat | cadmium dichloride | multiple interactions | ISO | Tle2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TLE2 mRNA | CTD | PMID:37325564 | Tle2 | Rat | caffeine | decreases phosphorylation | ISO | TLE2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of TLE2 protein | CTD | PMID:35688186 | Tle2 | Rat | carbon nanotube | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Tle2 | Rat | chlorpyrifos | increases expression | ISO | Tle2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of TLE2 mRNA | CTD | PMID:37019170 | Tle2 | Rat | cisplatin | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of TLE2 mRNA | CTD | PMID:27392435 | Tle2 | Rat | clofibrate | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of TLE2 mRNA | CTD | PMID:23811191 | Tle2 | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of TLE2 mRNA | CTD | PMID:24386269 | Tle2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of TLE2 mRNA | CTD | PMID:30556269 | Tle2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of TLE2 mRNA | CTD | PMID:30556269 | Tle2 | Rat | dexamethasone | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TLE2 mRNA | CTD | PMID:28628672 | Tle2 | Rat | diarsenic trioxide | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of TLE2 mRNA | CTD | PMID:20458559 | Tle2 | Rat | diarsenic trioxide | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of TLE2 mRNA | CTD | PMID:26705709 | Tle2 | Rat | Dibutyl phosphate | affects expression | ISO | TLE2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of TLE2 mRNA | CTD | PMID:37042841 | Tle2 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TLE2 mRNA | CTD | PMID:21266533 | Tle2 | Rat | dibutyl phthalate | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of TLE2 mRNA | CTD | PMID:17361019 and PMID:21266533 | Tle2 | Rat | dichloroacetic acid | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Dichloroacetic Acid results in decreased expression of TLE2 mRNA | CTD | PMID:28962523 | Tle2 | Rat | dioxygen | multiple interactions | ISO | Tle2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TLE2 mRNA | CTD | PMID:30529165 | Tle2 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of TLE2 mRNA | CTD | PMID:21551480 | Tle2 | Rat | dorsomorphin | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLE2 mRNA | CTD | PMID:27188386 | Tle2 | Rat | doxorubicin | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TLE2 mRNA | CTD | PMID:29803840 | Tle2 | Rat | elemental selenium | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Selenium results in increased expression of TLE2 mRNA | CTD | PMID:19244175 | Tle2 | Rat | entinostat | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | entinostat results in increased expression of TLE2 mRNA | CTD | PMID:26272509 and PMID:27188386 | Tle2 | Rat | entinostat | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLE2 mRNA | CTD | PMID:27188386 | Tle2 | Rat | folic acid | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of TLE2 mRNA | CTD | PMID:21867686 | Tle2 | Rat | FR900359 | increases phosphorylation | ISO | TLE2 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of TLE2 protein | CTD | PMID:37730182 | Tle2 | Rat | furan | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | furan results in decreased expression of TLE2 mRNA | CTD | PMID:24183702 | Tle2 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of TLE2 mRNA | CTD | PMID:25539665 | Tle2 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TLE2 mRNA | CTD | PMID:33387578 | Tle2 | Rat | hydrogen peroxide | affects expression | ISO | TLE2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of TLE2 mRNA | CTD | PMID:20044591 | Tle2 | Rat | indometacin | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TLE2 mRNA | CTD | PMID:28628672 | Tle2 | Rat | lead(0) | affects expression | ISO | TLE2 (Homo sapiens) | 6480464 | Lead affects the expression of TLE2 mRNA | CTD | PMID:28903495 | Tle2 | Rat | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of TLE2 mRNA | CTD | PMID:28801915 | Tle2 | Rat | methamphetamine | increases expression | ISO | Tle2 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of TLE2 mRNA | CTD | PMID:26307267 | Tle2 | Rat | methylseleninic acid | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | methylselenic acid results in increased expression of TLE2 mRNA | CTD | PMID:18548127 | Tle2 | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of TLE2 mRNA | CTD | PMID:22401849 | Tle2 | Rat | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of TLE2 mRNA | CTD | PMID:28801915 | Tle2 | Rat | nickel atom | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of TLE2 mRNA | CTD | PMID:24768652 and PMID:25583101 | Tle2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TLE2 mRNA | CTD | PMID:25729387 | Tle2 | Rat | paracetamol | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of TLE2 mRNA | CTD | PMID:17562736 | Tle2 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of TLE2 mRNA | CTD | PMID:32680482 | Tle2 | Rat | phenobarbital | affects expression | ISO | TLE2 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of TLE2 mRNA | CTD | PMID:19159669 | Tle2 | Rat | phenobarbital | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Phenobarbital affects the expression of TLE2 mRNA | CTD | PMID:23091169 | Tle2 | Rat | pirinixic acid | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of TLE2 mRNA | CTD | PMID:23811191 | Tle2 | Rat | progesterone | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Progesterone results in increased expression of TLE2 mRNA | CTD | PMID:21540246 | Tle2 | Rat | resveratrol | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of TLE2 mRNA | CTD | PMID:23557933 | Tle2 | Rat | SB 431542 | multiple interactions | ISO | TLE2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLE2 mRNA | CTD | PMID:27188386 | Tle2 | Rat | selenium atom | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Selenium results in increased expression of TLE2 mRNA | CTD | PMID:19244175 | Tle2 | Rat | silicon dioxide | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of TLE2 mRNA | CTD | PMID:25895662 | Tle2 | Rat | sodium arsenite | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TLE2 mRNA | CTD | PMID:34032870 | Tle2 | Rat | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of TLE2 mRNA | CTD | PMID:22110744 | Tle2 | Rat | tamoxifen | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of TLE2 mRNA | CTD | PMID:17555576 | Tle2 | Rat | tetrachloroethene | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of TLE2 mRNA | CTD | PMID:28973375 | Tle2 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TLE2 mRNA | CTD | PMID:31150632 | Tle2 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TLE2 mRNA] | CTD | PMID:31150632 | Tle2 | Rat | tetraphene | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | benz(a)anthracene results in decreased expression of TLE2 mRNA | CTD | PMID:26377693 | Tle2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TLE2 mRNA | CTD | PMID:23411599 and PMID:34492290 | Tle2 | Rat | titanium dioxide | decreases methylation | ISO | Tle2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of TLE2 gene and titanium dioxide results in decreased methylation of TLE2 promoter | CTD | PMID:35295148 | Tle2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TLE2 mRNA | CTD | PMID:25729387 | Tle2 | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of TLE2 gene | CTD | PMID:27618143 | Tle2 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of TLE2 mRNA | CTD | PMID:33387578 | Tle2 | Rat | triclosan | decreases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of TLE2 mRNA | CTD | PMID:30510588 | Tle2 | Rat | trimellitic anhydride | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of TLE2 mRNA | CTD | PMID:19042947 | Tle2 | Rat | triptonide | decreases expression | ISO | Tle2 (Mus musculus) | 6480464 | triptonide results in decreased expression of TLE2 mRNA | CTD | PMID:33045310 | Tle2 | Rat | valproic acid | increases expression | ISO | TLE2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TLE2 mRNA | CTD | PMID:19101580 | Tle2 | Rat | valproic acid | affects expression | ISO | Tle2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of TLE2 mRNA | CTD | PMID:17963808 | Tle2 | Rat | valproic acid | increases methylation | ISO | TLE2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of TLE2 gene | CTD | PMID:29154799 | |