Dync2i1 (dynein 2 intermediate chain 1) - Rat Genome Database

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Gene: Dync2i1 (dynein 2 intermediate chain 1) Rattus norvegicus
Analyze
Symbol: Dync2i1
Name: dynein 2 intermediate chain 1
RGD ID: 1306493
Description: Predicted to have dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to colocalize with interphase microtubule organizing center and spindle pole. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; genistein.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cytoplasmic dynein 2 intermediate chain 1; LOC314523; RGD1306493; similar to hypothetical protein FLJ10300; WD repeat domain 60; WD repeat-containing protein 60; Wdr60
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26137,133,418 - 137,189,937 (-)NCBI
Rnor_6.0 Ensembl6144,069,022 - 144,123,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06144,069,077 - 144,124,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06153,007,323 - 153,063,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46143,478,863 - 143,534,960 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16143,485,229 - 143,566,989 (-)NCBI
Celera6134,799,216 - 134,853,660 (-)NCBICelera
Cytogenetic Map6q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:22326026   PMID:22664934   PMID:23376485   PMID:23910462   PMID:25205765   PMID:25830415  


Genomics

Comparative Map Data
Dync2i1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26137,133,418 - 137,189,937 (-)NCBI
Rnor_6.0 Ensembl6144,069,022 - 144,123,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06144,069,077 - 144,124,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06153,007,323 - 153,063,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46143,478,863 - 143,534,960 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16143,485,229 - 143,566,989 (-)NCBI
Celera6134,799,216 - 134,853,660 (-)NCBICelera
Cytogenetic Map6q33NCBI
DYNC2I1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7158,856,558 - 158,956,747 (+)EnsemblGRCh38hg38GRCh38
GRCh387158,839,245 - 158,958,695 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377158,631,936 - 158,738,880 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367158,342,030 - 158,431,644 (+)NCBINCBI36hg18NCBI36
Celera7153,081,253 - 153,173,045 (+)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7152,387,759 - 152,477,997 (+)NCBIHuRef
CHM1_17158,657,218 - 158,746,574 (+)NCBICHM1_1
CRA_TCAGchr7v27157,852,877 - 157,941,993 (+)NCBI
Dync2i1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,169,881 - 116,226,665 (-)NCBIGRCm39mm39
GRCm39 Ensembl12116,169,882 - 116,226,642 (-)Ensembl
GRCm3812116,206,261 - 116,263,046 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,206,262 - 116,263,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712117,445,523 - 117,501,498 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612110,442,837 - 110,464,344 (-)NCBImm8
MGSCv3612116,681,849 - 116,704,995 (-)NCBImm8
Cytogenetic Map12F2NCBI
Dync2i1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555791,057,680 - 1,124,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555791,056,291 - 1,124,623 (+)NCBIChiLan1.0ChiLan1.0
DYNC2I1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17162,142,751 - 162,219,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7162,140,534 - 162,218,224 (+)Ensemblpanpan1.1panPan2
DYNC2I1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11620,810,735 - 20,859,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1620,810,345 - 20,859,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1621,315,043 - 21,362,048 (+)NCBI
ROS_Cfam_1.01622,541,514 - 22,590,144 (+)NCBI
UMICH_Zoey_3.11620,909,158 - 20,957,846 (+)NCBI
UNSW_CanFamBas_1.01621,493,172 - 21,541,474 (+)NCBI
UU_Cfam_GSD_1.01621,547,449 - 21,595,738 (+)NCBI
Dync2i1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118476,896 - 544,500 (-)NCBI
SpeTri2.0NW_004936856724,863 - 792,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC2I1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18508,277 - 555,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118507,163 - 555,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218777,589 - 793,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC2I1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121126,798,952 - 126,828,361 (+)NCBI
Dync2i1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624800213,589 - 301,066 (-)NCBI

Position Markers
D6Got189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,216,457 - 137,216,727 (+)MAPPER
Rnor_6.06144,152,817 - 144,153,084NCBIRnor6.0
Rnor_5.06153,089,470 - 153,089,737UniSTSRnor5.0
RGSC_v3.46143,563,372 - 143,563,640RGDRGSC3.4
RGSC_v3.46143,563,373 - 143,563,640UniSTSRGSC3.4
RGSC_v3.16143,569,560 - 143,569,827RGD
Celera6134,881,693 - 134,881,938UniSTS
RH 3.4 Map6937.4UniSTS
RH 3.4 Map6937.4RGD
RH 2.0 Map61190.6RGD
Cytogenetic Map6q33UniSTS
AI103063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,143,148 - 137,143,254 (+)MAPPER
Rnor_6.06144,078,195 - 144,078,300NCBIRnor6.0
Rnor_5.06153,016,441 - 153,016,546UniSTSRnor5.0
RGSC_v3.46143,488,593 - 143,488,698UniSTSRGSC3.4
Celera6134,808,433 - 134,808,538UniSTS
RH 3.4 Map6944.41UniSTS
Cytogenetic Map6q33UniSTS
RH133577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,133,448 - 137,133,628 (+)MAPPER
Rnor_6.06144,069,108 - 144,069,287NCBIRnor6.0
Rnor_6.06143,874,524 - 143,874,703NCBIRnor6.0
Rnor_5.06153,007,354 - 153,007,533UniSTSRnor5.0
Rnor_5.06152,815,354 - 152,815,533UniSTSRnor5.0
RGSC_v3.46143,478,894 - 143,479,073UniSTSRGSC3.4
Celera6134,799,247 - 134,799,426UniSTS
RH 3.4 Map6938.0UniSTS
Cytogenetic Map6q33UniSTS
BI303067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26137,165,460 - 137,165,616 (+)MAPPER
Rnor_6.06144,100,501 - 144,100,656NCBIRnor6.0
Rnor_5.06153,038,747 - 153,038,902UniSTSRnor5.0
RGSC_v3.46143,510,901 - 143,511,056UniSTSRGSC3.4
Celera6134,830,679 - 134,830,834UniSTS
RH 3.4 Map6938.09UniSTS
Cytogenetic Map6q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)699273921144273921Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)699273921144792678Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)6101207574147991367Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6104363890147991367Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6117355600147991367Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6127286494144745573Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6127286494147249902Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6127286494147991367Rat
2312560Pur20Proteinuria QTL 202.10.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6130561943144745573Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:112
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000006144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 73 21 41 11
Low 3 43 55 39 19 39 8 11 1 14 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006144   ⟹   ENSRNOP00000006144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6144,069,077 - 144,123,596 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087845   ⟹   ENSRNOP00000072019
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6144,069,022 - 144,123,729 (-)Ensembl
RefSeq Acc Id: NM_001191773   ⟹   NP_001178702
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,553 (-)NCBI
Rnor_6.06144,069,077 - 144,123,596 (-)NCBI
Rnor_5.06153,007,323 - 153,063,140 (-)NCBI
Celera6134,799,216 - 134,853,660 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240688   ⟹   XP_006240750
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,725 (-)NCBI
Rnor_6.06144,069,077 - 144,123,762 (-)NCBI
Rnor_5.06153,007,323 - 153,063,140 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594193   ⟹   XP_017449682
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,725 (-)NCBI
Rnor_6.06144,069,077 - 144,123,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594194   ⟹   XP_017449683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,526 (-)NCBI
Rnor_6.06144,069,077 - 144,123,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594195   ⟹   XP_017449684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,724 (-)NCBI
Rnor_6.06144,069,077 - 144,123,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594196   ⟹   XP_017449685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,525 (-)NCBI
Rnor_6.06144,069,077 - 144,123,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594197   ⟹   XP_017449686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,519 (-)NCBI
Rnor_6.06144,069,077 - 144,123,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594198   ⟹   XP_017449687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,189,882 (-)NCBI
Rnor_6.06144,069,077 - 144,124,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594199   ⟹   XP_017449688
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,189,882 (-)NCBI
Rnor_6.06144,069,077 - 144,124,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594200   ⟹   XP_017449689
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,188,522 (-)NCBI
Rnor_6.06144,069,077 - 144,123,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594201   ⟹   XP_017449690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06144,080,347 - 144,123,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112428   ⟹   XP_038968356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,189,882 (-)NCBI
RefSeq Acc Id: XM_039112429   ⟹   XP_038968357
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,189,882 (-)NCBI
RefSeq Acc Id: XM_039112430   ⟹   XP_038968358
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,133,418 - 137,189,937 (-)NCBI
RefSeq Acc Id: XR_001838171
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26137,143,664 - 137,188,726 (-)NCBI
Rnor_6.06144,078,731 - 144,123,762 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001178702   ⟸   NM_001191773
- UniProtKB: D3ZYV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240750   ⟸   XM_006240688
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449688   ⟸   XM_017594199
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449687   ⟸   XM_017594198
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449684   ⟸   XM_017594195
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017449682   ⟸   XM_017594193
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449689   ⟸   XM_017594200
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449686   ⟸   XM_017594197
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449683   ⟸   XM_017594194
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017449685   ⟸   XM_017594196
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017449690   ⟸   XM_017594201
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000006144   ⟸   ENSRNOT00000006144
RefSeq Acc Id: ENSRNOP00000072019   ⟸   ENSRNOT00000087845
RefSeq Acc Id: XP_038968358   ⟸   XM_039112430
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038968357   ⟸   XM_039112429
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038968356   ⟸   XM_039112428
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694908
Promoter ID:EPDNEW_R5431
Type:initiation region
Name:Wdr60_1
Description:WD repeat domain 60
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06144,123,746 - 144,123,806EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
6 144080973 144080974 G T snv LEW/Crl (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306493 AgrOrtholog
Ensembl Genes ENSRNOG00000004520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006144 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072019 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006144 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000087845 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDR60 UniProtKB/TrEMBL
KEGG Report rno:314523 UniProtKB/TrEMBL
NCBI Gene 314523 ENTREZGENE
PANTHER PTHR16022 UniProtKB/TrEMBL
PhenoGen Dync2i1 PhenoGen
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K1X3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYV1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-22 Dync2i1  dynein 2 intermediate chain 1  Wdr60  WD repeat domain 60  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Wdr60  WD repeat domain 60  RGD1306493_predicted  similar to hypothetical protein FLJ10300 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306493_predicted  similar to hypothetical protein FLJ10300 (predicted)  LOC314523_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314523_predicted  similar to hypothetical protein FLJ10300 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL