Slc22a14 (solute carrier family 22, member 14) - Rat Genome Database

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Gene: Slc22a14 (solute carrier family 22, member 14) Rattus norvegicus
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Symbol: Slc22a14
Name: solute carrier family 22, member 14
RGD ID: 1306470
Description: Predicted to enable riboflavin transmembrane transporter activity. Predicted to be involved in riboflavin transport and transmembrane transport. Predicted to act upstream of or within flagellated sperm motility and sperm capacitation. Predicted to be located in sperm principal piece. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC22A14 (solute carrier family 22 member 14); INTERACTS WITH bisphenol A; trichloroethene; 2,3',4,4',5-Pentachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC316061; solute carrier family 22 (organic cation transporter), member 14; solute carrier family 22 member 14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,772,275 - 127,794,222 (-)NCBIGRCr8
mRatBN7.28118,894,537 - 118,916,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,895,259 - 118,908,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,496,296 - 124,517,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,695,253 - 122,716,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,528,109 - 120,549,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,858,425 - 127,871,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,065,929 - 127,078,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,132,131 - 124,145,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,153,605 - 124,167,928 (-)NCBI
Celera8118,069,008 - 118,081,349 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Slc22a14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,772,275 - 127,794,222 (-)NCBIGRCr8
mRatBN7.28118,894,537 - 118,916,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,895,259 - 118,908,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,496,296 - 124,517,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,695,253 - 122,716,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,528,109 - 120,549,961 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,858,425 - 127,871,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,065,929 - 127,078,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,132,131 - 124,145,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,153,605 - 124,167,928 (-)NCBI
Celera8118,069,008 - 118,081,349 (-)NCBICelera
Cytogenetic Map8q32NCBI
SLC22A14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,278,832 - 38,318,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,282,294 - 38,318,575 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,323,785 - 38,360,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,322,449 - 38,334,863 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,322,430 - 38,335,069NCBI
Celera338,283,102 - 38,295,539 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,389,428 - 38,401,865 (+)NCBIHuRef
CHM1_1338,299,121 - 38,311,552 (+)NCBICHM1_1
T2T-CHM13v2.0338,284,541 - 38,324,319 (+)NCBIT2T-CHM13v2.0
Slc22a14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,998,521 - 119,019,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,998,523 - 119,019,473 (-)EnsemblGRCm39 Ensembl
GRCm389119,169,453 - 119,190,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,169,455 - 119,365,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,078,574 - 119,099,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,018,154 - 119,039,091 (-)NCBIMGSCv36mm8
Celera9119,637,344 - 119,658,281 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Slc22a14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554215,009,279 - 5,020,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554215,009,560 - 5,023,833 (-)NCBIChiLan1.0ChiLan1.0
LOC100994888
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,217,886 - 38,272,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,240,382 - 38,277,275 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,179,107 - 38,216,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,463,156 - 38,499,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,486,595 - 38,498,833 (+)Ensemblpanpan1.1panPan2
SLC22A14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,075,485 - 8,104,214 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,075,539 - 8,101,828 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,116,633 - 8,145,060 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,364,930 - 8,393,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,364,980 - 8,391,456 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,179,216 - 8,207,948 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,319,389 - 8,348,059 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,313,019 - 8,341,739 (+)NCBIUU_Cfam_GSD_1.0
Slc22a14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,347,314 - 194,387,615 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,486,083 - 27,500,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,487,459 - 27,501,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,149,231 - 23,159,598 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,148,924 - 23,162,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,363,455 - 25,399,166 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,097,989 - 1,111,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,098,235 - 1,110,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,829,218 - 9,842,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477319,969,763 - 19,980,009 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477319,964,690 - 19,980,122 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a14
186 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:113
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000055928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
RH144542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,895,405 - 118,895,662 (+)MAPPERmRatBN7.2
Rnor_6.08127,858,572 - 127,858,828NCBIRnor6.0
Rnor_5.08127,066,076 - 127,066,332UniSTSRnor5.0
RGSC_v3.48124,132,278 - 124,132,534UniSTSRGSC3.4
Celera8118,069,155 - 118,069,411UniSTS
RH 3.4 Map81290.3UniSTS
Cytogenetic Map8q32UniSTS


Expression


Sequence


RefSeq Acc Id: NM_001108193   ⟹   NP_001101663
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,275 - 127,794,150 (-)NCBI
mRatBN7.28118,894,537 - 118,916,416 (-)NCBI
Rnor_6.08127,858,425 - 127,871,192 (-)NCBI
Rnor_5.08127,065,929 - 127,078,390 (-)NCBI
RGSC_v3.48124,132,131 - 124,145,289 (-)RGD
Celera8118,069,008 - 118,081,349 (-)RGD
Sequence:
RefSeq Acc Id: NM_001393686   ⟹   NP_001380615
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,275 - 127,794,150 (-)NCBI
mRatBN7.28118,894,537 - 118,916,416 (-)NCBI
RefSeq Acc Id: XM_039081631   ⟹   XP_038937559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,137 (-)NCBI
mRatBN7.28118,894,537 - 118,916,323 (-)NCBI
RefSeq Acc Id: XM_039081633   ⟹   XP_038937561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,153 (-)NCBI
mRatBN7.28118,894,537 - 118,916,384 (-)NCBI
RefSeq Acc Id: XM_039081634   ⟹   XP_038937562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,120 (-)NCBI
mRatBN7.28118,894,537 - 118,916,309 (-)NCBI
RefSeq Acc Id: XM_039081635   ⟹   XP_038937563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,793,870 (-)NCBI
mRatBN7.28118,894,537 - 118,916,137 (-)NCBI
RefSeq Acc Id: XM_039081637   ⟹   XP_038937565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,137 (-)NCBI
mRatBN7.28118,894,537 - 118,916,323 (-)NCBI
RefSeq Acc Id: XM_039081639   ⟹   XP_038937567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,137 (-)NCBI
mRatBN7.28118,895,647 - 118,916,323 (-)NCBI
RefSeq Acc Id: XM_063265652   ⟹   XP_063121722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,140 (-)NCBI
RefSeq Acc Id: XM_063265653   ⟹   XP_063121723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,772,996 - 127,794,222 (-)NCBI
RefSeq Acc Id: NP_001101663   ⟸   NM_001108193
- Peptide Label: isoform 1
- UniProtKB: E9PU08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937561   ⟸   XM_039081633
- Peptide Label: isoform X1
- UniProtKB: E9PU08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937565   ⟸   XM_039081637
- Peptide Label: isoform X2
- UniProtKB: B4F7B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937559   ⟸   XM_039081631
- Peptide Label: isoform X1
- UniProtKB: E9PU08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937562   ⟸   XM_039081634
- Peptide Label: isoform X1
- UniProtKB: E9PU08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937563   ⟸   XM_039081635
- Peptide Label: isoform X1
- UniProtKB: E9PU08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937567   ⟸   XM_039081639
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001380615   ⟸   NM_001393686
- Peptide Label: isoform 2
- UniProtKB: B4F7B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121723   ⟸   XM_063265653
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063121722   ⟸   XM_063265652
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU08-F1-model_v2 AlphaFold E9PU08 1-608 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306470 AgrOrtholog
BioCyc Gene G2FUF-28799 BioCyc
Ensembl Genes ENSRNOG00000042259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055928 ENTREZGENE
  ENSRNOT00000055928.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
KEGG Report rno:316061 UniProtKB/TrEMBL
NCBI Gene 316061 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 14 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
  Sugar_tr UniProtKB/TrEMBL
PhenoGen Slc22a14 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042259 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A6I3V6_RAT UniProtKB/TrEMBL
  B4F7B0 ENTREZGENE, UniProtKB/TrEMBL
  E9PU08 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-19 Slc22a14  solute carrier family 22, member 14  Slc22a14  solute carrier family 22 (organic cation transporter), member 14   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc22a14  solute carrier family 22 (organic cation transporter), member 14   Slc22a14_predicted  solute carrier family 22 (organic cation transporter), member 14 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc22a14_predicted  solute carrier family 22 (organic cation transporter), member 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED