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Gene: L2hgdh (L-2-hydroxyglutarate dehydrogenase) Rattus norvegicus
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Symbol: L2hgdh
Name: L-2-hydroxyglutarate dehydrogenase
Description: Predicted to have (S)-2-hydroxy-acid oxidase activity and 2-hydroxyglutarate dehydrogenase activity. Predicted to be involved in cellular protein metabolic process. Predicted to localize to the integral component of membrane and mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; L-2-hydroxyglutaric aciduria; cerebellar ataxia; hereditary spastic paraplegia; and visual epilepsy. Orthologous to human L2HGDH (L-2-hydroxyglutarate dehydrogenase); PARTICIPATES IN butanoate metabolic pathway; INTERACTS WITH 2,6-dinitrotoluene; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: L-2-hydroxyglutarate dehydrogenase, mitochondrial; LOC314196; RGD1306250; similar to cDNA sequence BC016226
Orthologs:
Homo sapiens (human) : L2HGDH (L-2-hydroxyglutarate dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : L2hgdh (L-2-hydroxyglutarate dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : L2hgdh (L-2-hydroxyglutarate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Canis lupus familiaris (dog) : L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : L2hgdh (L-2-hydroxyglutarate dehydrogenase)
Sus scrofa (pig) : L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Chlorocebus sabaeus (green monkey) : L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Heterocephalus glaber (naked mole-rat) : L2hgdh (L-2-hydroxyglutarate dehydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0692,016,560 - 92,057,643 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,016,622 - 92,057,816 (-)Ensembl
Rnor_5.06101,466,089 - 101,507,172 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,730,715 - 91,771,825 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1691,735,909 - 91,775,259 (-)NCBI
Celera686,659,422 - 86,700,511 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on L2hgdh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306250
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.