Tll1 (tolloid-like 1) - Rat Genome Database

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Gene: Tll1 (tolloid-like 1) Rattus norvegicus
Analyze
Symbol: Tll1
Name: tolloid-like 1
RGD ID: 1306120
Description: Predicted to enable collagen binding activity and metalloendopeptidase activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290694; Tll; tolloid-like; tolloid-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81630,275,492 - 30,476,673 (+)NCBIGRCr8
mRatBN7.21625,509,146 - 25,710,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1625,509,146 - 25,709,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,872,934 - 29,070,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01632,307,140 - 32,504,735 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01628,257,416 - 28,456,869 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01627,399,467 - 27,597,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1627,399,467 - 27,597,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01627,269,834 - 27,466,134 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41628,433,106 - 28,641,870 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,369,379 - 28,640,803 (+)NCBI
Celera1625,585,144 - 25,784,010 (+)NCBICelera
Cytogenetic Map16p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. Clark TG, etal., Development. 1999 Jun;126(12):2631-42. doi: 10.1242/dev.126.12.2631.
2. Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial. Cresci S, etal., Circulation. 2011 Sep 27;124(13):1426-34. doi: 10.1161/CIRCULATIONAHA.111.029173. Epub 2011 Sep 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease. LaHaye S, etal., Circ Cardiovasc Genet. 2016 Aug;9(4):320-9. doi: 10.1161/CIRCGENETICS.115.001324. Epub 2016 Jul 14.
6. [Metalloproteinase Tolloid-like 1 gene mutation in Chinese patients with sporadic congenital heart diseases]. Li J, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2012 May;40(5):402-5.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Mutations in mammalian tolloid-like 1 gene detected in adult patients with ASD. Stańczak P, etal., Eur J Hum Genet. 2009 Mar;17(3):344-51. doi: 10.1038/ejhg.2008.175. Epub 2008 Oct 1.
Additional References at PubMed
PMID:12393877   PMID:15632090  


Genomics

Comparative Map Data
Tll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81630,275,492 - 30,476,673 (+)NCBIGRCr8
mRatBN7.21625,509,146 - 25,710,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1625,509,146 - 25,709,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,872,934 - 29,070,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01632,307,140 - 32,504,735 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01628,257,416 - 28,456,869 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01627,399,467 - 27,597,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1627,399,467 - 27,597,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01627,269,834 - 27,466,134 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41628,433,106 - 28,641,870 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,369,379 - 28,640,803 (+)NCBI
Celera1625,585,144 - 25,784,010 (+)NCBICelera
Cytogenetic Map16p13NCBI
TLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,873,237 - 166,104,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,873,237 - 166,104,457 (+)EnsemblGRCh38hg38GRCh38
GRCh374166,794,389 - 167,025,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364167,013,860 - 167,244,443 (+)NCBINCBI36Build 36hg18NCBI36
Build 344167,152,014 - 167,382,598NCBI
Celera4164,129,812 - 164,360,405 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4162,546,596 - 162,777,406 (+)NCBIHuRef
CHM1_14166,770,892 - 167,001,531 (+)NCBICHM1_1
T2T-CHM13v2.04169,219,854 - 169,450,476 (+)NCBIT2T-CHM13v2.0
Tll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39864,466,132 - 64,659,043 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl864,467,965 - 64,659,305 (-)EnsemblGRCm39 Ensembl
GRCm38864,013,098 - 64,206,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,014,931 - 64,206,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv37866,493,567 - 66,684,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36866,907,123 - 67,098,185 (-)NCBIMGSCv36mm8
Celera866,582,326 - 66,773,174 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.19NCBI
Tll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540339,299,461 - 39,491,638 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540339,299,461 - 39,491,638 (-)NCBIChiLan1.0ChiLan1.0
TLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23163,623,646 - 163,856,077 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,979,821 - 164,212,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04158,068,424 - 158,300,856 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14170,156,769 - 170,387,835 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4170,157,417 - 170,384,260 (+)Ensemblpanpan1.1panPan2
TLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,818,794 - 61,945,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,756,281 - 61,941,195 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1562,000,711 - 62,193,335 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,612,914 - 62,806,825 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,611,961 - 62,803,958 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,833,972 - 62,027,206 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,837,920 - 62,031,626 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01562,231,911 - 62,426,446 (+)NCBIUU_Cfam_GSD_1.0
Tll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494318,371,728 - 18,570,362 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555193 - 96,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557 - 198,382 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl842,856,469 - 43,092,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1842,855,883 - 43,094,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2844,819,641 - 44,941,352 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17112,231,084 - 112,455,131 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7112,233,283 - 112,455,803 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603792,102,663 - 92,325,436 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475810,762,274 - 10,959,327 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475810,761,480 - 10,960,057 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tll1
1112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:133
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000065642
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

Markers in Region
Tll  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,708,886 - 25,709,075 (+)MAPPERmRatBN7.2
Rnor_6.01627,596,586 - 27,596,772NCBIRnor6.0
Rnor_5.01627,465,480 - 27,465,666UniSTSRnor5.0
RGSC_v3.41628,641,216 - 28,641,402UniSTSRGSC3.4
Celera1625,783,356 - 25,783,542UniSTS
Cytogenetic Map16p13UniSTS
BI295547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,511,887 - 25,512,084 (+)MAPPERmRatBN7.2
Rnor_6.01627,402,209 - 27,402,405NCBIRnor6.0
Rnor_5.01627,272,576 - 27,272,772UniSTSRnor5.0
RGSC_v3.41628,435,848 - 28,436,044UniSTSRGSC3.4
Celera1625,587,886 - 25,588,082UniSTS
RH 3.4 Map16295.51UniSTS
Cytogenetic Map16p13UniSTS
AA799516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,579,738 - 25,579,832 (+)MAPPERmRatBN7.2
Rnor_6.01627,467,556 - 27,467,649NCBIRnor6.0
Rnor_5.01627,337,923 - 27,338,016UniSTSRnor5.0
RGSC_v3.41628,504,100 - 28,504,193UniSTSRGSC3.4
Celera1625,655,253 - 25,655,346UniSTS
Cytogenetic Map16p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9
Low 3 41 22 6 10 6 8 10 65 35 41 11 8
Below cutoff 2 15 15 8 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065642   ⟹   ENSRNOP00000058943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1625,509,146 - 25,709,543 (+)Ensembl
Rnor_6.0 Ensembl1627,399,467 - 27,597,240 (+)Ensembl
RefSeq Acc Id: NM_001106081   ⟹   NP_001099551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81630,275,492 - 30,475,886 (+)NCBI
mRatBN7.21625,509,146 - 25,709,543 (+)NCBI
Rnor_6.01627,399,467 - 27,597,240 (+)NCBI
Rnor_5.01627,269,834 - 27,466,134 (+)NCBI
RGSC_v3.41628,433,106 - 28,641,870 (+)RGD
Celera1625,585,144 - 25,784,010 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094815   ⟹   XP_038950743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81630,384,962 - 30,476,673 (+)NCBI
mRatBN7.21625,618,617 - 25,710,330 (+)NCBI
RefSeq Acc Id: XM_039094816   ⟹   XP_038950744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81630,422,726 - 30,476,673 (+)NCBI
mRatBN7.21625,656,028 - 25,710,330 (+)NCBI
RefSeq Acc Id: XM_063275708   ⟹   XP_063131778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81630,276,160 - 30,476,673 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099551 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950743 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950744 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131778 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058943
  ENSRNOP00000058943.4
Reference Protein Sequences
RefSeq Acc Id: NP_001099551   ⟸   NM_001106081
- Peptide Label: precursor
- UniProtKB: A6KFP6 (UniProtKB/TrEMBL),   D3Z8U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058943   ⟸   ENSRNOT00000065642
RefSeq Acc Id: XP_038950743   ⟸   XM_039094815
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950744   ⟸   XM_039094816
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131778   ⟸   XM_063275708
- Peptide Label: isoform X1
Protein Domains
CUB   EGF-like   Peptidase M12A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8U5-F1-model_v2 AlphaFold D3Z8U5 1-1012 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700069
Promoter ID:EPDNEW_R10591
Type:multiple initiation site
Name:Tll1_1
Description:tolloid-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01627,399,455 - 27,399,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306120 AgrOrtholog
BioCyc Gene G2FUF-11617 BioCyc
Ensembl Genes ENSRNOG00000033528 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065642 ENTREZGENE
  ENSRNOT00000065642.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro BMP_1/tolloid-like UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  ZnMP_TLD/BMP1 UniProtKB/TrEMBL
KEGG Report rno:678743 UniProtKB/TrEMBL
NCBI Gene Tll1 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 1 UniProtKB/TrEMBL
  OVOCHYMASE-RELATED UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
PhenoGen Tll1 PhenoGen
PIRSF BMP_1/tolloid-like UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033528 RatGTEx
SMART CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6KFP6 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8U5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-17 Tll1  tolloid-like 1   LOC678743  similar to tolloid-like  Data merged from RGD:1596941 1643240 APPROVED
2008-04-30 Tll1  tolloid-like 1   Tll1_predicted  tolloid-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC678743  similar to tolloid-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Tll1_predicted  tolloid-like 1 (predicted)  Tll_predicted  tolloid-like (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Tll_predicted  tolloid-like (predicted)      Symbol and Name status set to approved 70820 APPROVED