Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | HS6ST3 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HS6ST3 mRNA | CTD | PMID:24763279 | 1,2-dichloroethane | decreases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of HS6ST3 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HS6ST3 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HS6ST3 mRNA | CTD | PMID:29097150 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hs6st3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HS6ST3 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of HS6ST3 mRNA | CTD | PMID:18648102 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of HS6ST3 mRNA | CTD | PMID:24780913 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of HS6ST3 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of HS6ST3 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of HS6ST3 mRNA | CTD | PMID:32234424 and PMID:35690182 | aflatoxin B1 | increases methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of HS6ST3 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of HS6ST3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of HS6ST3 mRNA | CTD | PMID:21934132 | antirheumatic drug | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of HS6ST3 mRNA | CTD | PMID:24449571 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of HS6ST3 gene | CTD | PMID:35440735 | benzo[a]pyrene | affects expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the expression of HS6ST3 mRNA | CTD | PMID:21714911 | benzo[a]pyrene | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HS6ST3 mRNA | CTD | PMID:32234424 and PMID:35690182 | benzo[a]pyrene | affects methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HS6ST3 3' UTR and Benzo(a)pyrene affects the methylation of HS6ST3 intron | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | Hs6st3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of HS6ST3 intron | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HS6ST3 5' UTR more ... | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HS6ST3 mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HS6ST3 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of HS6ST3 gene | CTD | PMID:28505145 | chlorpyrifos | decreases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of HS6ST3 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Hs6st3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of HS6ST3 mRNA | CTD | PMID:21603599 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of HS6ST3 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of HS6ST3 mRNA | CTD | PMID:26033743 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of HS6ST3 mRNA | CTD | PMID:26577399 | dioxygen | affects methylation | ISO | Hs6st3 (Mus musculus) | 6480464 | Oxygen deficiency affects the methylation of HS6ST3 promoter | CTD | PMID:24205000 | dioxygen | increases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of HS6ST3 mRNA | CTD | PMID:24205000 | dorsomorphin | multiple interactions | ISO | HS6ST3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | entinostat results in decreased expression of HS6ST3 mRNA | CTD | PMID:27188386 | ethanol | increases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | Ethanol results in increased expression of HS6ST3 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Hs6st3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene | CTD | PMID:20938992 | glyphosate | decreases expression | ISO | Hs6st3 (Mus musculus) | 6480464 | Glyphosate results in decreased expression of HS6ST3 mRNA | CTD | PMID:35489704 | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of HS6ST3 gene | CTD | PMID:31011160 | L-methionine | multiple interactions | ISO | Hs6st3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene | CTD | PMID:20938992 | Lasiocarpine | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | lasiocarpine results in decreased expression of HS6ST3 mRNA | CTD | PMID:32234424 and PMID:35690182 | methotrexate | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of HS6ST3 mRNA | CTD | PMID:24449571 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] affects the methylation of HS6ST3 gene | CTD | PMID:33148267 | N-Nitrosopyrrolidine | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of HS6ST3 mRNA | CTD | PMID:32234424 and PMID:35690182 | nickel atom | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Nickel results in decreased expression of HS6ST3 mRNA | CTD | PMID:25583101 | O-methyleugenol | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of HS6ST3 mRNA | CTD | PMID:32234424 and PMID:35690182 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HS6ST3 mRNA | CTD | PMID:33387578 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] affects the methylation of HS6ST3 gene | CTD | PMID:33148267 | permethrin | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Permethrin results in decreased expression of HS6ST3 mRNA | CTD | PMID:37047231 | SB 431542 | multiple interactions | ISO | HS6ST3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA | CTD | PMID:27188386 | sunitinib | decreases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HS6ST3 mRNA | CTD | PMID:31533062 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of HS6ST3 mRNA | CTD | PMID:33387578 | valproic acid | decreases methylation | ISO | HS6ST3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of HS6ST3 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HS6ST3 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | HS6ST3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HS6ST3 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | HS6ST3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA | CTD | PMID:27188386 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of HS6ST3 gene | CTD | PMID:31682807 | |