Gpr158 (G protein-coupled receptor 158) - Rat Genome Database

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Gene: Gpr158 (G protein-coupled receptor 158) Rattus norvegicus
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Symbol: Gpr158
Name: G protein-coupled receptor 158
RGD ID: 1305841
Description: Predicted to enable G protein-coupled glycine receptor activity and enzyme activator activity. Predicted to be involved in several processes, including positive regulation of neurotransmitter secretion; protein localization to plasma membrane; and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Orthologous to human GPR158 (G protein-coupled receptor 158); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291352; metabotropic glycine receptor; mGlyR; probable G-protein coupled receptor 158; similar to G protein-coupled receptor 158 isoform a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,685,879 - 89,152,659 (+)NCBIGRCr8
mRatBN7.21783,777,625 - 84,244,428 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,834,569 - 84,244,428 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1787,313,345 - 87,722,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01791,148,711 - 91,558,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01785,165,655 - 85,575,174 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01788,215,131 - 88,654,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,215,834 - 88,651,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01789,902,429 - 90,335,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41795,323,129 - 95,730,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11795,333,685 - 95,738,420 (+)NCBI
Celera1784,638,349 - 84,841,527 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22689652   PMID:36634900  


Genomics

Comparative Map Data
Gpr158
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,685,879 - 89,152,659 (+)NCBIGRCr8
mRatBN7.21783,777,625 - 84,244,428 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,834,569 - 84,244,428 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1787,313,345 - 87,722,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01791,148,711 - 91,558,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01785,165,655 - 85,575,174 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01788,215,131 - 88,654,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,215,834 - 88,651,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01789,902,429 - 90,335,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41795,323,129 - 95,730,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11795,333,685 - 95,738,420 (+)NCBI
Celera1784,638,349 - 84,841,527 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
GPR158
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381025,175,001 - 25,602,229 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1025,174,802 - 25,602,229 (+)EnsemblGRCh38hg38GRCh38
GRCh371025,463,930 - 25,891,158 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361025,504,296 - 25,931,164 (+)NCBINCBI36Build 36hg18NCBI36
Celera1025,165,702 - 25,598,388 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1025,124,846 - 25,550,757 (+)NCBIHuRef
CHM1_11025,464,879 - 25,891,900 (+)NCBICHM1_1
T2T-CHM13v2.01025,193,234 - 25,626,794 (+)NCBIT2T-CHM13v2.0
Gpr158
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39221,372,378 - 21,835,355 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl221,372,353 - 21,835,358 (+)EnsemblGRCm39 Ensembl
GRCm38221,367,567 - 21,830,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl221,367,542 - 21,830,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37221,289,194 - 21,752,171 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36221,285,321 - 21,748,298 (+)NCBIMGSCv36mm8
Celera221,246,752 - 21,710,952 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map214.92NCBI
Gpr158
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554293,641,709 - 4,053,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554293,641,764 - 4,053,860 (-)NCBIChiLan1.0ChiLan1.0
GPR158
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2837,876,693 - 38,299,274 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11037,881,597 - 38,304,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01025,352,131 - 25,777,652 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11025,721,768 - 26,143,954 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1025,722,127 - 26,140,997 (+)Ensemblpanpan1.1panPan2
GPR158
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127,969,781 - 8,379,657 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,971,800 - 8,378,198 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26,664,668 - 7,073,497 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026,168,494 - 6,578,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26,168,494 - 6,578,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.125,538,054 - 5,948,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025,616,670 - 6,026,418 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025,782,879 - 6,192,914 (-)NCBIUU_Cfam_GSD_1.0
Gpr158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934424,670,867 - 25,061,002 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936484836,700 - 1,226,162 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936484835,886 - 1,224,450 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR158
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1049,862,312 - 50,202,453 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11049,862,312 - 50,202,748 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,286,186 - 55,471,492 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR158
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1924,903,263 - 25,310,817 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605130,863,478 - 31,284,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr158
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247963,302,496 - 3,806,219 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247963,299,535 - 3,806,346 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr158
3481 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:197
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000034098
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
D17Got107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,150,477 - 84,150,623 (+)MAPPERmRatBN7.2
Rnor_6.01788,559,593 - 88,559,738NCBIRnor6.0
Rnor_5.01790,242,677 - 90,242,822UniSTSRnor5.0
Celera1784,731,947 - 84,732,092UniSTS
RH 3.4 Map17868.8RGD
RH 3.4 Map17868.8UniSTS
Cytogenetic Map17q12.3UniSTS
BE119491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21783,922,999 - 83,923,164 (+)MAPPERmRatBN7.2
Rnor_6.01788,336,752 - 88,336,916NCBIRnor6.0
Rnor_5.01790,022,350 - 90,022,514UniSTSRnor5.0
RGSC_v3.41795,414,071 - 95,414,235UniSTSRGSC3.4
Celera1783,176,898 - 83,177,062UniSTS
RH 3.4 Map17876.4UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 6 22 113 75 74 49 11 49 6 134 53 93 18 56 25

Sequence


Ensembl Acc Id: ENSRNOT00000034098   ⟹   ENSRNOP00000038884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1783,834,569 - 84,244,428 (+)Ensembl
Rnor_6.0 Ensembl1788,215,834 - 88,651,476 (+)Ensembl
RefSeq Acc Id: NM_001170326   ⟹   NP_001163797
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81788,742,823 - 89,152,658 (+)NCBI
mRatBN7.21783,834,569 - 84,244,428 (+)NCBI
Rnor_6.01788,215,131 - 88,654,352 (+)NCBI
Rnor_5.01789,902,429 - 90,335,831 (+)NCBI
RGSC_v3.41795,323,129 - 95,730,463 (+)RGD
Celera1784,638,349 - 84,841,527 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095563   ⟹   XP_038951491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81788,685,879 - 89,152,659 (+)NCBI
mRatBN7.21783,777,625 - 84,244,422 (+)NCBI
RefSeq Acc Id: XM_039095564   ⟹   XP_038951492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81788,685,900 - 89,152,659 (+)NCBI
mRatBN7.21783,777,644 - 84,244,422 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001163797 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951492 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A6L0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038884.6
RefSeq Acc Id: NP_001163797   ⟸   NM_001170326
- Peptide Label: precursor
- UniProtKB: D4A6L0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038884   ⟸   ENSRNOT00000034098
RefSeq Acc Id: XP_038951491   ⟸   XM_039095563
- Peptide Label: isoform X1
- UniProtKB: D4A6L0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951492   ⟸   XM_039095564
- Peptide Label: isoform X1
- UniProtKB: D4A6L0 (UniProtKB/Swiss-Prot)
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6L0-F1-model_v2 AlphaFold D4A6L0 1-1202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305841 AgrOrtholog
BioCyc Gene G2FUF-8498 BioCyc
Ensembl Genes ENSRNOG00000024832 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034098.7 UniProtKB/TrEMBL
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR158/179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291352 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 158-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR32546 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr158 PhenoGen
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024832 RatGTEx
UniProt A0A0A0MY13_RAT UniProtKB/TrEMBL
  D4A6L0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Gpr158  G protein-coupled receptor 158  LOC686523  similar to G protein-coupled receptor 158 isoform a  Data merged from RGD:1596374 1643240 APPROVED
2013-05-24 Gpr158  G protein-coupled receptor 158  LOC678897  similar to G protein-coupled receptor 158 isoform a  Data merged from RGD:1595524 1643240 APPROVED
2008-04-30 Gpr158  G protein-coupled receptor 158   Gpr158_predicted  G protein-coupled receptor 158 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC686523  similar to G protein-coupled receptor 158 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC678897  similar to G protein-coupled receptor 158 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Gpr158_predicted  G protein-coupled receptor 158 (predicted)      Symbol and Name status set to approved 70820 APPROVED