Tspan14 (tetraspanin 14) - Rat Genome Database

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Gene: Tspan14 (tetraspanin 14) Rattus norvegicus
Analyze
Symbol: Tspan14
Name: tetraspanin 14
RGD ID: 1305714
Description: Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Predicted to be located in cell surface and tetraspanin-enriched microdomain. Predicted to be active in plasma membrane. Orthologous to human TSPAN14 (tetraspanin 14); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC306324; RGD1305714; similar to tetraspanin similar to TM4SF9; tetraspanin-14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21616,784,242 - 16,841,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1616,783,234 - 16,841,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1616,852,777 - 16,880,132 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01617,979,528 - 18,006,887 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01616,905,672 - 16,933,029 (-)NCBIRnor_WKY
Rnor_6.01617,538,855 - 17,595,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1617,538,855 - 17,595,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01617,421,546 - 17,478,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,340,946 - 17,397,964 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,339,921 - 17,398,046 (-)NCBI
Celera1617,010,568 - 17,067,598 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23035126   PMID:23091066  


Genomics

Comparative Map Data
Tspan14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21616,784,242 - 16,841,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1616,783,234 - 16,841,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1616,852,777 - 16,880,132 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01617,979,528 - 18,006,887 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01616,905,672 - 16,933,029 (-)NCBIRnor_WKY
Rnor_6.01617,538,855 - 17,595,960 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1617,538,855 - 17,595,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01617,421,546 - 17,478,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,340,946 - 17,397,964 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,339,921 - 17,398,046 (-)NCBI
Celera1617,010,568 - 17,067,598 (-)NCBICelera
Cytogenetic Map16p14NCBI
TSPAN14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381080,454,310 - 80,522,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1080,454,265 - 80,533,124 (+)EnsemblGRCh38hg38GRCh38
GRCh371082,214,066 - 82,282,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361082,204,047 - 82,269,366 (+)NCBINCBI36Build 36hg18NCBI36
Build 341082,204,046 - 82,269,364NCBI
Celera1076,204,371 - 76,272,722 (+)NCBICelera
Cytogenetic Map10q23.1NCBI
HuRef1076,057,216 - 76,125,170 (+)NCBIHuRef
CHM1_11082,497,044 - 82,565,383 (+)NCBICHM1_1
T2T-CHM13v2.01081,323,409 - 81,391,729 (+)NCBIT2T-CHM13v2.0
Tspan14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,628,384 - 40,689,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,628,402 - 40,688,764 (-)EnsemblGRCm39 Ensembl
GRCm381440,906,427 - 40,967,073 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1440,906,445 - 40,966,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv371441,719,733 - 41,780,096 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361439,815,157 - 39,875,520 (-)NCBIMGSCv36mm8
Celera1437,065,722 - 37,125,273 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
Tspan14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955510448,668 - 490,635 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955510463,548 - 490,635 (+)NCBIChiLan1.0ChiLan1.0
TSPAN14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11080,462,234 - 80,521,771 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1080,464,131 - 80,521,771 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01076,854,589 - 76,922,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TSPAN14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,589,840 - 29,635,448 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl429,586,264 - 29,634,694 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,705,463 - 29,760,708 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,883,249 - 29,938,436 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,883,065 - 29,938,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,752,837 - 29,807,967 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,955,243 - 30,010,372 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,309,656 - 30,364,838 (+)NCBIUU_Cfam_GSD_1.0
Tspan14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721351,064,861 - 51,125,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936716285,389 - 342,947 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936716285,395 - 342,953 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPAN14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1482,305,714 - 82,364,659 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11482,305,594 - 82,364,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,914,194 - 88,972,588 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSPAN14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1951,317,651 - 51,381,388 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl951,319,166 - 51,347,968 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604811,639,848 - 11,706,005 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tspan14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248416,603,374 - 6,633,579 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248416,603,373 - 6,655,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tspan14
387 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:104
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000014772
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat

Markers in Region
AW521715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21616,842,238 - 16,842,401 (-)MAPPERmRatBN7.2
Rnor_6.01617,537,812 - 17,537,974NCBIRnor6.0
Rnor_5.01617,420,273 - 17,420,435UniSTSRnor5.0
RGSC_v3.41617,399,223 - 17,399,385UniSTSRGSC3.4
Celera1617,068,465 - 17,068,627UniSTS
RH 3.4 Map16164.11UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 2 3 74 35 34 11 2
Low 7 6 8 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014772   ⟹   ENSRNOP00000014772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1616,783,234 - 16,841,400 (-)Ensembl
Rnor_6.0 Ensembl1617,538,855 - 17,595,960 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095616   ⟹   ENSRNOP00000097225
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1616,783,234 - 16,841,400 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113745   ⟹   ENSRNOP00000087472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1616,783,308 - 16,796,270 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117906   ⟹   ENSRNOP00000078197
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1616,783,308 - 16,796,950 (-)Ensembl
RefSeq Acc Id: NM_001169127   ⟹   NP_001162598
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21616,784,242 - 16,841,368 (-)NCBI
Rnor_6.01617,538,855 - 17,595,960 (+)NCBI
Rnor_5.01617,421,546 - 17,478,815 (+)NCBI
RGSC_v3.41617,340,946 - 17,397,964 (-)RGD
Celera1617,010,568 - 17,067,598 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001162598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90878 (Get FASTA)   NCBI Sequence Viewer  
  EDL90879 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001162598   ⟸   NM_001169127
- UniProtKB: D4A0Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014772   ⟸   ENSRNOT00000014772
RefSeq Acc Id: ENSRNOP00000087472   ⟸   ENSRNOT00000113745
RefSeq Acc Id: ENSRNOP00000078197   ⟸   ENSRNOT00000117906
RefSeq Acc Id: ENSRNOP00000097225   ⟸   ENSRNOT00000095616

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0Z1-F1-model_v2 AlphaFold D4A0Z1 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699970
Promoter ID:EPDNEW_R10492
Type:initiation region
Name:Tspan14_1
Description:tetraspanin 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01617,538,835 - 17,538,895EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305714 AgrOrtholog
BioCyc Gene G2FUF-11914 BioCyc
Ensembl Genes ENSRNOG00000010813 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014772 ENTREZGENE
  ENSRNOP00000014772.4 UniProtKB/TrEMBL
  ENSRNOP00000078197.1 UniProtKB/TrEMBL
  ENSRNOP00000087472.1 UniProtKB/TrEMBL
  ENSRNOP00000097225.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014772 ENTREZGENE
  ENSRNOT00000014772.7 UniProtKB/TrEMBL
  ENSRNOT00000095616.1 UniProtKB/TrEMBL
  ENSRNOT00000113745.1 UniProtKB/TrEMBL
  ENSRNOT00000117906.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1450.10 UniProtKB/TrEMBL
InterPro Tetraspanin UniProtKB/TrEMBL
  Tetraspanin_CS UniProtKB/TrEMBL
  Tetraspanin_EC2 UniProtKB/TrEMBL
  Tetraspanin_sub UniProtKB/TrEMBL
KEGG Report rno:306324 UniProtKB/TrEMBL
NCBI Gene 306324 ENTREZGENE
PANTHER PTHR19282 UniProtKB/TrEMBL
Pfam Tetraspannin UniProtKB/TrEMBL
PhenoGen Tspan14 PhenoGen
PIRSF Tetraspanin UniProtKB/TrEMBL
PROSITE TM4_1 UniProtKB/TrEMBL
Superfamily-SCOP Tetraspanin UniProtKB/TrEMBL
UniProt A0A8I5Y772_RAT UniProtKB/TrEMBL
  A0A8I6ARC5_RAT UniProtKB/TrEMBL
  A0A8I6GG14_RAT UniProtKB/TrEMBL
  D4A0Z1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tspan14  tetraspanin 14   Tspan14_predicted  tetraspanin 14 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tspan14_predicted  tetraspanin 14 (predicted)  RGD1305714_predicted  similar to tetraspanin similar to TM4SF9 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305714_predicted  similar to tetraspanin similar to TM4SF9 (predicted)  LOC306324_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306324_predicted  similar to tetraspanin similar to TM4SF9 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL