Ash2l (ASH2 like histone lysine methyltransferase complex subunit) - Rat Genome Database

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Gene: Ash2l (ASH2 like histone lysine methyltransferase complex subunit) Rattus norvegicus
Analyze
Symbol: Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
RGD ID: 1305632
Description: Predicted to enable beta-catenin binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of cell population proliferation; response to estrogen; and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within DNA damage response and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of euchromatin and histone methyltransferase complex. Biomarker of schizophrenia. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ash2 (absent, small, or homeotic)-like; ash2 (absent, small, or homeotic)-like (Drosophila); LOC290829; set1/Ash2 histone methyltransferase complex subunit ASH2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,943,527 - 72,966,791 (+)NCBIGRCr8
mRatBN7.21666,242,205 - 66,264,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,242,212 - 66,264,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,520,834 - 71,542,299 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,927,142 - 74,948,609 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,167,036 - 70,188,505 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,011,315 - 71,033,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,011,332 - 71,032,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,675,994 - 70,697,849 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,617,717 - 70,639,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,604,210 - 70,639,337 (+)NCBI
Celera1664,152,097 - 64,173,546 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex. Mackowiak M, etal., Eur Neuropsychopharmacol. 2014 Feb;24(2):271-89. doi: 10.1016/j.euroneuro.2013.05.013. Epub 2013 Aug 8.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
Additional References at PubMed
PMID:12477932   PMID:14992727   PMID:15199122   PMID:15960975   PMID:16603732   PMID:17355966   PMID:17500065   PMID:17998332   PMID:18245475   PMID:18838538   PMID:19556245   PMID:20463296  
PMID:22723415  


Genomics

Comparative Map Data
Ash2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,943,527 - 72,966,791 (+)NCBIGRCr8
mRatBN7.21666,242,205 - 66,264,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,242,212 - 66,264,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,520,834 - 71,542,299 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,927,142 - 74,948,609 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,167,036 - 70,188,505 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,011,315 - 71,033,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,011,332 - 71,032,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,675,994 - 70,697,849 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,617,717 - 70,639,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,604,210 - 70,639,337 (+)NCBI
Celera1664,152,097 - 64,173,546 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
ASH2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,105,493 - 38,140,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,105,493 - 38,144,076 (+)EnsemblGRCh38hg38GRCh38
GRCh37837,963,011 - 37,997,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,082,168 - 38,116,385 (+)NCBINCBI36Build 36hg18NCBI36
Build 34838,082,222 - 38,116,215NCBI
Celera836,915,527 - 36,949,763 (+)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,498,048 - 36,532,653 (+)NCBIHuRef
CHM1_1838,164,558 - 38,199,166 (+)NCBICHM1_1
T2T-CHM13v2.0838,382,461 - 38,417,070 (+)NCBIT2T-CHM13v2.0
Ash2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,306,028 - 26,337,722 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,306,024 - 26,337,722 (-)EnsemblGRCm39 Ensembl
GRCm38825,816,000 - 25,847,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,815,996 - 25,847,694 (-)EnsemblGRCm38mm10GRCm38
MGSCv37826,927,342 - 26,958,142 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,282,420 - 27,306,314 (-)NCBIMGSCv36mm8
Celera827,285,099 - 27,316,003 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Ash2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,731,506 - 13,761,684 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,731,651 - 13,757,475 (+)NCBIChiLan1.0ChiLan1.0
ASH2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,668,224 - 56,703,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,385,206 - 32,419,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,408,151 - 37,442,080 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,583,265 - 34,618,183 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,583,265 - 34,618,183 (+)Ensemblpanpan1.1panPan2
ASH2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,334,419 - 27,366,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,334,420 - 27,366,950 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,851,728 - 27,884,205 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,233,604 - 29,265,821 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,233,605 - 29,265,789 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,455,901 - 27,488,143 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,033,174 - 28,065,614 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,072,602 - 28,104,856 (-)NCBIUU_Cfam_GSD_1.0
Ash2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,941,735 - 49,971,854 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,489,522 - 1,518,849 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,489,483 - 1,519,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASH2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,386,425 - 48,417,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,386,426 - 48,417,560 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,511,516 - 55,552,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASH2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,125,359 - 36,163,142 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660525,828,630 - 5,863,832 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ash2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,502,512 - 5,531,446 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,502,708 - 5,531,541 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ash2l
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:227
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000020181
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH140073  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map16621.91UniSTS
Cytogenetic Map16q12.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020181   ⟹   ENSRNOP00000020181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,242,212 - 66,264,061 (+)Ensembl
Rnor_6.0 Ensembl1671,011,341 - 71,032,790 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086891   ⟹   ENSRNOP00000068617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,242,212 - 66,264,061 (+)Ensembl
Rnor_6.0 Ensembl1671,011,332 - 71,032,474 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100676   ⟹   ENSRNOP00000094978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,242,494 - 66,264,061 (+)Ensembl
RefSeq Acc Id: NM_001106089   ⟹   NP_001099559
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,944,961 - 72,966,410 (+)NCBI
mRatBN7.21666,242,230 - 66,263,680 (+)NCBI
Rnor_6.01671,011,341 - 71,032,790 (+)NCBI
Rnor_5.01670,675,994 - 70,697,849 (+)NCBI
RGSC_v3.41670,617,717 - 70,639,166 (+)RGD
Celera1664,152,097 - 64,173,546 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253303   ⟹   XP_006253365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,943,527 - 72,966,791 (+)NCBI
mRatBN7.21666,242,205 - 66,264,064 (+)NCBI
Rnor_6.01671,011,315 - 71,033,171 (+)NCBI
Rnor_5.01670,675,994 - 70,697,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253304   ⟹   XP_006253366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,945,180 - 72,966,791 (+)NCBI
mRatBN7.21666,242,465 - 66,264,064 (+)NCBI
Rnor_6.01671,011,594 - 71,033,171 (+)NCBI
Rnor_5.01670,675,994 - 70,697,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063275243   ⟹   XP_063131313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,945,180 - 72,966,791 (+)NCBI
RefSeq Acc Id: NP_001099559   ⟸   NM_001106089
- UniProtKB: A6IW01 (UniProtKB/TrEMBL),   A0A8I6ASM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253365   ⟸   XM_006253303
- Peptide Label: isoform X1
- UniProtKB: D3ZTV7 (UniProtKB/TrEMBL),   A0A8I6ASM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253366   ⟸   XM_006253304
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JT90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020181   ⟸   ENSRNOT00000020181
RefSeq Acc Id: ENSRNOP00000068617   ⟸   ENSRNOT00000086891
RefSeq Acc Id: ENSRNOP00000094978   ⟸   ENSRNOT00000100676
RefSeq Acc Id: XP_063131313   ⟸   XM_063275243
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JT90 (UniProtKB/TrEMBL)
Protein Domains
B30.2/SPRY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JT90-F1-model_v2 AlphaFold A0A0G2JT90 1-629 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700171
Promoter ID:EPDNEW_R10688
Type:multiple initiation site
Name:Ash2l_1
Description:ASH2 like histone lysine methyltransferase complex subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,011,339 - 71,011,399EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305632 AgrOrtholog
BioCyc Gene G2FUF-10980 BioCyc
Ensembl Genes ENSRNOG00000014875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020181.8 UniProtKB/TrEMBL
  ENSRNOT00000086891.2 UniProtKB/TrEMBL
  ENSRNOT00000100676.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.90.980.20 UniProtKB/TrEMBL
InterPro ASH2 UniProtKB/TrEMBL
  ASH2-like_PHD UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  B302 UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
KEGG Report rno:290829 UniProtKB/TrEMBL
NCBI Gene 290829 ENTREZGENE
PANTHER PTHR10598 UniProtKB/TrEMBL
  SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 UniProtKB/TrEMBL
Pfam ASH2L-like_WH UniProtKB/TrEMBL
  PHD_ash2p_like UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
PhenoGen Ash2l PhenoGen
PROSITE B302_SPRY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014875 RatGTEx
SMART SPRY UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
UniProt A0A0G2JT90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASM7 ENTREZGENE, UniProtKB/TrEMBL
  A6IW01 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTV7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Ash2l  ASH2 like histone lysine methyltransferase complex subunit  Ash2l  ash2 (absent, small, or homeotic)-like (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ash2l  ash2 (absent, small, or homeotic)-like (Drosophila)   Ash2l_predicted  ash2 (absent, small, or homeotic)-like (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ash2l_predicted  ash2 (absent, small, or homeotic)-like (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED