Metap1 (methionyl aminopeptidase 1)

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Gene: Metap1 (methionyl aminopeptidase 1) Rattus norvegicus

Analyze

Symbol:

Metap1

Name:

methionyl aminopeptidase 1

RGD ID:

1305545

Description:

Predicted to enable metalloaminopeptidase activity. Predicted to be involved in platelet aggregation and protein maturation. Predicted to be active in cytosol. Orthologous to human METAP1 (methionyl aminopeptidase 1); INTERACTS WITH bisphenol A; fenvalerate; fipronil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC295500; methionine aminopeptidase 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	METAP1 (methionyl aminopeptidase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Metap1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Metap1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	METAP1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	METAP1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Metap1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	METAP1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	METAP1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Metap1 (methionyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	METAP1 (methionyl aminopeptidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Metap1 (methionyl aminopeptidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	metap1 (methionyl aminopeptidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG13630	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	map-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	metap1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	226,991,305 - 227,024,360 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	226,991,301 - 227,024,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	234,740,035 - 234,773,125 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	232,639,760 - 232,672,849 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	227,504,445 - 227,537,534 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	243,744,620 - 243,777,673 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	243,744,620 - 243,777,673 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	262,279,056 - 262,312,345 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	235,995,228 - 236,028,564 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	235,981,694 - 236,015,641 (-)	NCBI
Celera	2	219,147,349 - 219,180,340 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

clobetasol (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

fumagillin (ISO)

furan (EXP)

menadione (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

platelet aggregation (ISO)

protein maturation (IEA,ISO)

protein modification process (IEA)

proteolysis (IEA)

Cellular Component

cytosol (IBA)

Molecular Function

aminopeptidase activity (ISO)

initiator methionyl aminopeptidase activity (IEA)

metal ion binding (IEA)

metalloaminopeptidase activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23382103

Genomics

Comparative Map Data

Metap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	226,991,305 - 227,024,360 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	226,991,301 - 227,024,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	234,740,035 - 234,773,125 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	232,639,760 - 232,672,849 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	227,504,445 - 227,537,534 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	243,744,620 - 243,777,673 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	243,744,620 - 243,777,673 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	262,279,056 - 262,312,345 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	235,995,228 - 236,028,564 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	235,981,694 - 236,015,641 (-)	NCBI
Celera	2	219,147,349 - 219,180,340 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

METAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	98,995,721 - 99,062,809 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	98,995,659 - 99,062,809 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	99,916,872 - 99,983,960 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	100,175,620 - 100,202,983 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	100,313,774 - 100,341,137	NCBI
Celera	4	97,214,261 - 97,281,435 (+)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI
HuRef	4	95,655,807 - 95,722,944 (+)	NCBI		HuRef
CHM1_1	4	99,893,768 - 99,960,938 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	102,310,655 - 102,377,714 (+)	NCBI		T2T-CHM13v2.0

Metap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	138,164,721 - 138,195,143 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	138,164,717 - 138,195,276 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	138,458,960 - 138,489,382 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	138,458,956 - 138,489,515 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	138,121,924 - 138,152,346 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	138,396,347 - 138,426,769 (-)	NCBI		MGSCv36	mm8
Celera	3	144,881,648 - 144,911,869 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI

Metap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	9,276,062 - 9,300,516 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	9,211,813 - 9,302,001 (+)	NCBI	ChiLan1.0	ChiLan1.0

METAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	97,336,588 - 97,404,042 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	91,394,445 - 91,461,882 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	102,085,891 - 102,125,934 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	102,091,987 - 102,125,934 (+)	Ensembl	panpan1.1		panPan2

METAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	21,201,019 - 21,241,164 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	21,192,948 - 21,239,996 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	20,688,967 - 20,756,979 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	21,358,917 - 21,427,066 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	21,358,397 - 21,427,061 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	21,325,013 - 21,392,943 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	21,151,678 - 21,219,743 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	18,675,938 - 18,744,040 (-)	NCBI		UU_Cfam_GSD_1.0

Metap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	20,472,238 - 20,529,551 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	3,815,694 - 3,873,009 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936520	3,815,693 - 3,873,003 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METAP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	121,288,690 - 121,352,459 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	121,285,793 - 121,352,612 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	130,476,632 - 130,537,571 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	47,114,609 - 47,181,611 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	47,114,505 - 47,180,118 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	25,545,104 - 25,629,423 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Metap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004625024	63,001 - 157,891 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004625024	63,001 - 157,721 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Metap1
178 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	548
Count of miRNA genes:	261
Interacting mature miRNAs:	330
Transcripts:	ENSRNOT00000017579
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat

Markers in Region

RH130329

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	226,992,561 - 226,992,748 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	243,745,877 - 243,746,063	NCBI	Rnor6.0
Rnor_5.0	2	262,280,313 - 262,280,499	UniSTS	Rnor5.0
RGSC_v3.4	2	235,996,485 - 235,996,671	UniSTS	RGSC3.4
Celera	2	219,148,606 - 219,148,792	UniSTS
RH 3.4 Map	2	1606.3	UniSTS
Cytogenetic Map	2	q44	UniSTS

RH142492

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	226,999,790 - 226,999,920 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	243,753,106 - 243,753,235	NCBI	Rnor6.0
Rnor_5.0	2	262,287,542 - 262,287,671	UniSTS	Rnor5.0
RGSC_v3.4	2	236,003,714 - 236,003,843	UniSTS	RGSC3.4
Celera	2	219,155,835 - 219,155,964	UniSTS
RH 3.4 Map	2	1595.1	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017579 ⟹ ENSRNOP00000017579

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	226,991,301 - 227,024,434 (-)	Ensembl
Rnor_6.0 Ensembl	2	243,744,620 - 243,777,673 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106081 ⟹ ENSRNOP00000096177

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	226,991,301 - 227,024,434 (-)	Ensembl

RefSeq Acc Id:

NM_001106476 ⟹ NP_001099946

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	226,991,305 - 227,024,360 (-)	NCBI
Rnor_6.0	2	243,744,620 - 243,777,673 (-)	NCBI
Rnor_5.0	2	262,279,056 - 262,312,345 (-)	NCBI
RGSC_v3.4	2	235,995,228 - 236,028,564 (-)	RGD
Celera	2	219,147,349 - 219,180,340 (-)	RGD

Sequence:

show sequence

CTGAGTTCCTCCCCCGGCTGGGTCGCTCTCTCTCTCTCTCTCCCCTCCCTTTGGCGGTTCCTCC
CTCCTCCGGCAGCCAGGCAGCATGGCGGCGGTGGAGACACGGGTGTGCGAGACGGACGGCTGCA
GCAGCGAGGCCAAGCTCCAGTGTCCCACCTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTG
CTCGCAGGAATGCTTTAAAGGAAGCTGGGCGACTCACAAGTTACTACATAAGAAAGCAAAAGAT
GAAAAGGCAAAGCGAGAAGTATGTTCCTGGACTCTAGAAGGTGATGTGAACACTGACCCGTGGG
CAGGCTATCGGTACACTGGTAAACTCAGACCACATTATCCACTGATGCCAACACGGCCAGTGCC
CAGTTACATTCAGAGGCCGGACTATGCTGACCATCCCTTAGGAATGTCTGAATCCGAGCAAGCT
CTTAAAGGGACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGACTTGTGT
GCAGGCTTGCCAGAGAAGTTTTGGACATTGCTGCTGGGATGATTAAAGCAGGTGTAACTACTGA
AGAAATTGACCACGCTGTACACTTAGCATGCATTGCAAGAAACTGCTATCCTTCCCCCTTGAAT
TACTATAACTTCCCAAAGTCTTGCTGTACCTCAGTGAATGAAGTCATCTGCCATGGGATTCCAG
ACAGGCGGCCTTTGCAAGAAGGTGATATTGTTAATGTGGACATCACTCTCTATCGGAACGGCTA
TCACGGGGATCTAAACGAGACCTTTTTCGTTGGAGATGTGGATGAAGGAGCACGGAAACTCGTT
CAGACTACATATGAATGCCTGATGCAAGCCGTCGATGCAGTGAAGCCTGGCGTCCGATACAGAG
AACTGGGAAACATCATTCAGAAACATGCCCAGGCAAATGGATTCTCAGTTGTTCGAAGCTATTG
TGGACATGGGATCCACAAACTTTTCCATACAGCCCCCAACGTACCACACTATGCCAAAAATAAA
GCGGTTGGTGTGATGAAGTCGGGCCATGTGTTTACAATCGAGCCAATGATTTGTGAAGGTGGAT
GGCAGGATGAGACCTGGCCAGATGGCTGGACTGCAGTGACGAGGGACGGGAAAAGATCCGCTCA
GTTTGAGCACACTCTGCTGGTCACGGACACTGGCTGTGAGATTCTCACCCGGAGACTCGATAGT
GCTCGGCCTCATTTCATGTCCCAGTTTTAATTTCTCTCAAGATGCATAACATCCGAACACCATC
TCGTACTGTGCATTTTATTGAAAGTACAGAAATGAAGTGTTGTTGTTTTTTTTTTTTAAGTCGC
CCGTTTTGTTTTGAGTGTGGAGGAGAGTGGACTCCAGCACTGGGTGTGTGTCCTCAGGGGCAGA
GAAGAATAAAGGAAACATTGCTTACTGCCTCCCGTGCCTGGCCTCACCCCCTCAGTTTTCTGTA
CTGTGTTTTCTTCTTTGCCCCTTGCGCACTTGACCTAAATCTGCCCGTCATTGCGTTGTCACTG
CCACAGACCAGCCGCCAAGGGCCAGCTGCTGTCCAGGAGAAGGTGGAAGATGAGAAGTCTTGAA
ACTTTAGCAACATGTTGCTCCAGATTTTTATTATATATTGATATATATGGAAATATATATGCAT
ACATTTTAAATTCCATACACGTGATTACTGAACACTAGATGACTGTCGGTCTGGGTTGATTCTG
CTTTGACAGGATTATCTGTTCTCATAAATGGATCCATAACTCGCTAGTGAGTAATTCCTAGTCA
GGACCTGGTCTGCTCCCCTCACCATGCTGATTATTTATCTTGTCTGTCTATAGGGAAGCCTGCA
GTGTGGATGGTGTCAGTGAGGGAGTAGTTAGACTCACTTGGGAGGTTATCAGACTTGTAAGGTC
TGGTGTGTGGCAGCAGCTGTGGGGAGTTTTACAACGCACTGCTGCTTCAGACCTCTGTTTGGTC
AGAGATGTGAGGGAAGAAGCCCCCTTTCTTCAGAAACTTGGGTTGTAAGGGCACCCCTCTGGAG
TACTCAGAGAAGAATGGGCTGTCCTGTGGCAGGTGAAGGGGAGAATTCCAAATGTCCCCAGTGG
GAGCACAGTTGTGGGTGGCTGCGAGCTACCATTTTGTAAATGACAGCAGTGAGAAAGGAACGAG
TTGCAGTGCTGTAAGCACTCAGTATGCATGCTGCTACCCTGTATGCAAATGCACTCACCTCTGT
AGTTGAGAGTCTCGTCAGAAATGACCGTGGTGCCTGGAATCTGGGCTCCTCAGTGGTTGTTCAA
ATACAAGTGGAGACACACCAGATGATAAAGTTGTCATGAGAGTATCCTTGATTTCTGGTTGTCT
CATGACTTTATTCCAGTATACTTTGATACCGCTGACACATACTTCAAGACATCTTTCCCAGAGT
GCCTCAGACCTTATTGCTTTAAGAGAATGATGATAATGTTTTCATGACTTTATTTTAAATGATT
TAGTAAAGTGATTGAATCTGGTGTGGACTTCTGGGTGTGTGTGTGTTTAAAGTTTTTATCAAAC
TGTAATATTTGTGAATGGAATGCCTTGTAATATGAATGTTAATATAATATGTAAAGGGAGATTA
AACGTTTGAATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099946	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82321	(Get FASTA)	NCBI Sequence Viewer
	EDL82322	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099946 ⟸ NM_001106476

- UniProtKB:

D3ZE72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREV
CSWTLEGDVNTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQI
KLLSSEDIEGMRLVCRLAREVLDIAAGMIKAGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKS
CCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGDVDEGARKLVQTTYECL
MQAVDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKS
GHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
QF

hide sequence

RefSeq Acc Id:

ENSRNOP00000017579 ⟸ ENSRNOT00000017579

RefSeq Acc Id:

ENSRNOP00000096177 ⟸ ENSRNOT00000106081

Protein Domains

MYND-like zinc finger Peptidase M24

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZE72-F1-model_v2	AlphaFold	D3ZE72	1-386	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691789

Promoter ID:

EPDNEW_R2314

Type:

multiple initiation site

Name:

Metap1_1

Description:

methionyl aminopeptidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	243,777,599 - 243,777,659	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305545	AgrOrtholog
BioCyc Gene	G2FUF-51062	BioCyc
BioCyc Pathway	PWY-7799 [Arg/N-end rule pathway (eukaryotic)]	BioCyc
	PWY-7800 [Ac/N-end rule pathway]	BioCyc
Ensembl Genes	ENSRNOG00000012947	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017579	ENTREZGENE
	ENSRNOP00000017579.5	UniProtKB/TrEMBL
	ENSRNOP00000096177.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017579	ENTREZGENE
	ENSRNOT00000017579.6	UniProtKB/TrEMBL
	ENSRNOT00000106081.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.230.10	UniProtKB/TrEMBL
InterPro	Creatinase/aminopeptidase-like	UniProtKB/TrEMBL
	Pept_M24_MAP	UniProtKB/TrEMBL
	Pept_M24_structural-domain	UniProtKB/TrEMBL
	Pept_M24A_MAP1	UniProtKB/TrEMBL
	zf-C6H2	UniProtKB/TrEMBL
KEGG Report	rno:295500	UniProtKB/TrEMBL
NCBI Gene	295500	ENTREZGENE
PANTHER	METHIONINE AMINOPEPTIDASE	UniProtKB/TrEMBL
	METHIONINE AMINOPEPTIDASE 1	UniProtKB/TrEMBL
Pfam	Peptidase_M24	UniProtKB/TrEMBL
	zf-C6H2	UniProtKB/TrEMBL
PhenoGen	Metap1	PhenoGen
PRINTS	MAPEPTIDASE	UniProtKB/TrEMBL
PROSITE	MAP_1	UniProtKB/TrEMBL
Superfamily-SCOP	Peptidase_M24_cat_core	UniProtKB/TrEMBL
TIGRFAMs	met_pdase_I	UniProtKB/TrEMBL
UniProt	A0A8I6ASW2_RAT	UniProtKB/TrEMBL
	D3ZE72	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Metap1	methionyl aminopeptidase 1	Metap1_predicted	methionyl aminopeptidase 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Metap1_predicted	methionyl aminopeptidase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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