Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of IKBIP mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | affects expression | ISO | Ikbip (Mus musculus) | 6480464 | ethylene dichloride affects the expression of IKBIP mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IKBIP mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Estradiol results in decreased expression of IKBIP mRNA | CTD | PMID:23019147 | 17beta-estradiol | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of IKBIP mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IKBIP mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IKBIP mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IKBIP mRNA | CTD | PMID:15034205 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBIP mRNA] | CTD | PMID:15034205 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of IKBIP mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Ikbip (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of IKBIP promoter | CTD | PMID:26251327 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | Fenretinide results in decreased expression of IKBIP mRNA | CTD | PMID:28973697 | 5-fluorouracil | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of IKBIP mRNA | CTD | PMID:17982676 | 5-fluorouracil | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | TP53 protein promotes the reaction [Fluorouracil results in increased expression of IKBIP mRNA] | CTD | PMID:17982676 | aflatoxin B1 | affects expression | ISO | IKBIP (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of IKBIP protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of IKBIP mRNA | CTD | PMID:21632981 | antimycin A | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Antimycin A results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | aristolochic acid A | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of IKBIP mRNA and aristolochic acid I results in decreased expression of IKBIP protein | CTD | PMID:33212167 | atrazine | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Atrazine results in decreased expression of IKBIP mRNA | CTD | PMID:22378314 | avobenzone | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | avobenzone results in increased expression of IKBIP mRNA | CTD | PMID:31016361 | benzo[a]pyrene | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IKBIP mRNA] | CTD | PMID:15034205 | benzo[a]pyrene | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of IKBIP mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of IKBIP mRNA | CTD | PMID:15034205 and PMID:19770486 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bis(2-ethylhexyl) phthalate | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of IKBIP mRNA | CTD | PMID:31163220 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of IKBIP protein | CTD | PMID:31163220 | bisphenol A | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | bisphenol A results in increased expression of IKBIP mRNA | CTD | PMID:23798566 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of IKBIP mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of IKBIP mRNA and bisphenol A results in decreased expression of IKBIP protein | CTD | PMID:29275510 and PMID:34186270 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of IKBIP mRNA | CTD | PMID:25181051 | bisphenol F | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | bisphenol F results in increased expression of IKBIP protein | CTD | PMID:34186270 | bleomycin A2 | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Bleomycin results in increased expression of IKBIP mRNA | CTD | PMID:36087614 | butan-1-ol | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of IKBIP mRNA | CTD | PMID:29432896 | cadmium atom | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBIP mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBIP mRNA | CTD | PMID:35301059 | carbon nanotube | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cisplatin | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Cisplatin results in increased expression of IKBIP mRNA | CTD | PMID:21151649 | copper(II) sulfate | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of IKBIP mRNA | CTD | PMID:19549813 | Cuprizon | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Cuprizone co-treated with Haloperidol] results in increased expression of IKBIP protein | CTD | PMID:34122009 | cyclosporin A | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of IKBIP mRNA | CTD | PMID:19770486 | cyclosporin A | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of IKBIP mRNA | CTD | PMID:25562108 | cyclosporin A | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of IKBIP mRNA | CTD | PMID:20106945 | deguelin | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | deguelin results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | diazinon | increases methylation | ISO | IKBIP (Homo sapiens) | 6480464 | Diazinon results in increased methylation of IKBIP gene | CTD | PMID:22964155 | dicrotophos | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of IKBIP mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IKBIP mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of IKBIP mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | entinostat results in increased expression of IKBIP mRNA | CTD | PMID:27188386 | epoxiconazole | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | epoxiconazole results in increased expression of IKBIP mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of IKBIP mRNA | CTD | PMID:23649840 | fenvalerate | decreases expression | EXP | | 6480464 | fenvalerate results in decreased expression of IKBIP mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IKBIP mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of IKBIP mRNA | CTD | PMID:23649840 | fragrance | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Perfume results in increased expression of IKBIP mRNA | CTD | PMID:24768652 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of IKBIP mRNA | CTD | PMID:33387578 | haloperidol | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Cuprizone co-treated with Haloperidol] results in increased expression of IKBIP protein | CTD | PMID:34122009 | hydrogen peroxide | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IKBIP protein | CTD | PMID:18951874 | inulin | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IKBIP mRNA | CTD | PMID:36331819 | iron dichloride | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of IKBIP mRNA | CTD | PMID:35984750 | ivermectin | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of IKBIP protein | CTD | PMID:32959892 | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of IKBIP mRNA | CTD | PMID:20080153 | methyl methanesulfonate | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of IKBIP mRNA | CTD | PMID:23649840 | methylparaben | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | methylparaben results in decreased expression of IKBIP mRNA | CTD | PMID:31745603 | nickel atom | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Nickel results in increased expression of IKBIP mRNA | CTD | PMID:25583101 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of IKBIP mRNA | CTD | PMID:25729387 | paracetamol | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of IKBIP mRNA | CTD | PMID:22230336 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of IKBIP mRNA | CTD | PMID:27153767 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ikbip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IKBIP mRNA | CTD | PMID:36331819 | perfluorooctanoic acid | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of IKBIP protein | CTD | PMID:26879310 | phenylmercury acetate | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of IKBIP mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IKBIP mRNA | CTD | PMID:27188386 | picoxystrobin | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | pirinixic acid | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of IKBIP mRNA | CTD | PMID:20813756 | pyrimidifen | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | pyrimidifen results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | quercetin | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Quercetin results in increased expression of IKBIP mRNA | CTD | PMID:21632981 | rotenone | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Rotenone results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | SB 431542 | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IKBIP mRNA | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of IKBIP mRNA | CTD | PMID:19073995 | sunitinib | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Sunitinib results in increased expression of IKBIP mRNA | CTD | PMID:31533062 | tebufenpyrad | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of IKBIP mRNA | CTD | PMID:33512557 | temozolomide | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Temozolomide results in increased expression of IKBIP mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of IKBIP mRNA | CTD | PMID:27339419 and PMID:31919559 | theophylline | multiple interactions | ISO | IKBIP (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IKBIP protein | CTD | PMID:18951874 | titanium dioxide | decreases expression | ISO | Ikbip (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of IKBIP mRNA | CTD | PMID:19464567 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of IKBIP mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of IKBIP mRNA | CTD | PMID:25729387 | urethane | decreases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Urethane results in decreased expression of IKBIP mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | Ikbip (Mus musculus) | 6480464 | Valproic Acid results in increased expression of IKBIP mRNA | CTD | PMID:19136453 and PMID:21427059 | valproic acid | affects expression | ISO | IKBIP (Homo sapiens) | 6480464 | Valproic Acid affects the expression of IKBIP mRNA | CTD | PMID:23179753 | valproic acid | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of IKBIP mRNA | CTD | PMID:25192806 and PMID:27188386 | vorinostat | increases expression | ISO | IKBIP (Homo sapiens) | 6480464 | vorinostat results in increased expression of IKBIP mRNA | CTD | PMID:27188386 | |