Gtpbp3 (GTP binding protein 3) - Rat Genome Database

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Gene: Gtpbp3 (GTP binding protein 3) Rattus norvegicus
Analyze
Symbol: Gtpbp3
Name: GTP binding protein 3
RGD ID: 1305367
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be located in nucleus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTP binding protein 3 (mitochondrial); GTP-binding protein 3; LOC290633; tRNA modification GTPase GTPBP3, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,175,766 - 18,180,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,175,766 - 18,180,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,226,809 - 18,231,900 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01619,359,482 - 19,364,473 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01618,279,747 - 18,284,838 (+)NCBIRnor_WKY
Rnor_6.01619,897,135 - 19,902,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,896,986 - 19,902,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,758,699 - 19,763,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,659,339 - 18,664,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,659,336 - 18,664,439 (+)NCBI
Celera1618,380,702 - 18,385,801 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Gtpbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,175,766 - 18,180,857 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,175,766 - 18,180,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,226,809 - 18,231,900 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01619,359,482 - 19,364,473 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01618,279,747 - 18,284,838 (+)NCBIRnor_WKY
Rnor_6.01619,897,135 - 19,902,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,896,986 - 19,902,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,758,699 - 19,763,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,659,339 - 18,664,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,659,336 - 18,664,439 (+)NCBI
Celera1618,380,702 - 18,385,801 (+)NCBICelera
Cytogenetic Map16p14NCBI
GTPBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,334,982 - 17,342,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1917,334,920 - 17,342,731 (+)EnsemblGRCh38hg38GRCh38
GRCh371917,445,791 - 17,453,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,309,364 - 17,314,530 (+)NCBINCBI36Build 36hg18NCBI36
Celera1917,350,088 - 17,355,271 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,012,217 - 17,019,987 (+)NCBIHuRef
CHM1_11917,445,227 - 17,452,976 (+)NCBICHM1_1
T2T-CHM13v2.01917,469,817 - 17,477,573 (+)NCBIT2T-CHM13v2.0
Gtpbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,938,788 - 71,952,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,940,747 - 71,952,227 (+)EnsemblGRCm39 Ensembl
GRCm38871,486,144 - 71,499,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,488,103 - 71,499,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,012,002 - 74,017,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,417,092 - 74,422,389 (+)NCBIMGSCv36mm8
MGSCv36870,872,407 - 70,877,705 (+)NCBIMGSCv36mm8
Celera873,999,199 - 74,003,692 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
Gtpbp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955524899,475 - 903,168 (-)NCBIChiLan1.0ChiLan1.0
GTPBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,797,130 - 17,804,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,797,131 - 17,804,481 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,822,786 - 16,830,787 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GTPBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,422,653 - 45,427,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,423,089 - 45,426,574 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,335,604 - 45,340,476 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,908,930 - 45,913,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,908,930 - 45,913,676 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,145,446 - 45,150,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,555,343 - 45,560,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,831,437 - 45,836,311 (-)NCBIUU_Cfam_GSD_1.0
Gtpbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,978,805 - 203,982,556 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,527,670 - 3,531,494 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365963,527,903 - 3,532,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GTPBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,352,026 - 60,357,176 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,352,012 - 60,355,403 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GTPBP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,844,678 - 15,847,517 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,593,124 - 3,598,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gtpbp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908615,181 - 619,914 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908616,831 - 619,953 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gtpbp3
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:189
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000060355
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat

Markers in Region
RH131780  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,180,387 - 18,180,745 (+)MAPPERmRatBN7.2
mRatBN7.21618,180,441 - 18,180,745 (+)MAPPERmRatBN7.2
Rnor_6.01619,901,811 - 19,902,114NCBIRnor6.0
Rnor_6.01619,901,757 - 19,902,114NCBIRnor6.0
Rnor_5.01619,763,375 - 19,763,678UniSTSRnor5.0
Rnor_5.01619,763,321 - 19,763,678UniSTSRnor5.0
RGSC_v3.41618,663,972 - 18,664,329UniSTSRGSC3.4
RGSC_v3.41618,664,026 - 18,664,329UniSTSRGSC3.4
Celera1618,385,386 - 18,385,689UniSTS
Celera1618,385,332 - 18,385,689UniSTS
RH 3.4 Map16181.1UniSTS
Cytogenetic Map16p14UniSTS
UniSTS:235923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,179,484 - 18,179,855 (+)MAPPERmRatBN7.2
Rnor_6.01619,900,854 - 19,901,224NCBIRnor6.0
Rnor_5.01619,762,418 - 19,762,788UniSTSRnor5.0
RGSC_v3.41618,663,068 - 18,663,438UniSTSRGSC3.4
Celera1618,384,429 - 18,384,799UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 2 2 1 2 43 18 25
Low 3 31 55 39 18 39 8 11 31 17 16 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060355   ⟹   ENSRNOP00000057102
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,175,766 - 18,180,857 (+)Ensembl
Rnor_6.0 Ensembl1619,896,986 - 19,902,245 (+)Ensembl
RefSeq Acc Id: NM_001011919   ⟹   NP_001011919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21618,175,766 - 18,180,857 (+)NCBI
Rnor_6.01619,897,135 - 19,902,226 (+)NCBI
Rnor_5.01619,758,699 - 19,763,790 (+)NCBI
RGSC_v3.41618,659,339 - 18,664,441 (+)RGD
Celera1618,380,702 - 18,385,801 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011919 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87083 (Get FASTA)   NCBI Sequence Viewer  
  Q5PQQ1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001011919   ⟸   NM_001011919
- Peptide Label: precursor
- UniProtKB: Q5PQQ1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057102   ⟸   ENSRNOT00000060355
Protein Domains
TrmE-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQQ1-F1-model_v2 AlphaFold Q5PQQ1 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305367 AgrOrtholog
BioCyc Gene G2FUF-11847 BioCyc
BioCyc Pathway PWY-7889 [tRNA-uridine 2-thiolation (mammalian mitochondria)] BioCyc
Ensembl Genes ENSRNOG00000023403 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000057102 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060355 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.430 UniProtKB/Swiss-Prot
  3.30.1360.120 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189218 IMAGE-MGC_LOAD
InterPro G_TrmE UniProtKB/Swiss-Prot
  GTP-bd_TrmE_N UniProtKB/Swiss-Prot
  GTP_binding_domain UniProtKB/Swiss-Prot
  GTPase_MnmE UniProtKB/Swiss-Prot
  MnmE_dom2 UniProtKB/Swiss-Prot
  MnmE_helical UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot
KEGG Report rno:290633 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94548 IMAGE-MGC_LOAD
NCBI Gene 290633 ENTREZGENE
Pfam MMR_HSR1 UniProtKB/Swiss-Prot
  MnmE_helical UniProtKB/Swiss-Prot
  TrmE_N UniProtKB/Swiss-Prot
PhenoGen Gtpbp3 PhenoGen
PROSITE G_TRME UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGRFAMs mnmE_trmE_thdF UniProtKB/Swiss-Prot
  small_GTP UniProtKB/Swiss-Prot
UniProt GTPB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Gtpbp3  GTP binding protein 3  Gtpbp3  GTP binding protein 3 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Gtpbp3  GTP binding protein 3 (mitochondrial)  Gtpbp3  GTP binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gtpbp3  GTP binding protein 3  Gtpbp3_predicted  GTP binding protein 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gtpbp3_predicted  GTP binding protein 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED