Dr1 (down-regulator of transcription 1) - Rat Genome Database

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Gene: Dr1 (down-regulator of transcription 1) Rattus norvegicus
Analyze
Symbol: Dr1
Name: down-regulator of transcription 1
RGD ID: 1305201
Description: Is predicted to contribute to transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; chromatin organization; and regulation of transcription by RNA polymerase II. Predicted to localize to Ada2/Gcn5/Ada3 transcription activator complex; RNA polymerase II transcription regulator complex; and negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1); PARTICIPATES IN RNA polymerase II transcription initiation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: down-regulator of transcription 1, TBP-binding (negative cofactor 2); LOC100910207; LOC289881; NC2-beta; negative cofactor 2-beta; protein Dr1-like; TATA-binding protein-associated phosphoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,458,223 - 1,469,578 (-)NCBI
Rnor_6.0 Ensembl142,463,643 - 2,474,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,621,026 - 1,632,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0142,463,651 - 2,475,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,462,579 - 2,473,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,005,938 - 2,017,291 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,005,938 - 2,017,291 (-)NCBI
Celera141,480,040 - 1,491,393 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18838386   PMID:19103755   PMID:20508642  


Genomics

Comparative Map Data
Dr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,458,223 - 1,469,578 (-)NCBI
Rnor_6.0 Ensembl142,463,643 - 2,474,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,621,026 - 1,632,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0142,463,651 - 2,475,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,462,579 - 2,473,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,005,938 - 2,017,291 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,005,938 - 2,017,291 (-)NCBI
Celera141,480,040 - 1,491,393 (-)NCBICelera
Cytogenetic Map14p22NCBI
DR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl193,345,907 - 93,369,493 (+)EnsemblGRCh38hg38GRCh38
GRCh38193,345,907 - 93,369,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37193,811,464 - 93,835,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,584,066 - 93,600,737 (+)NCBINCBI36hg18NCBI36
Build 34193,523,498 - 93,540,167NCBI
Celera192,065,544 - 92,082,224 (+)NCBI
Cytogenetic Map1p22.1NCBI
HuRef191,933,028 - 91,949,702 (+)NCBIHuRef
CHM1_1193,926,443 - 93,943,112 (+)NCBICHM1_1
Dr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,416,763 - 108,428,387 (+)NCBIGRCm39mm39
GRCm39 Ensembl5108,416,763 - 108,428,392 (+)Ensembl
GRCm385108,268,897 - 108,280,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,268,897 - 108,280,526 (+)EnsemblGRCm38mm10GRCm38
MGSCv375108,697,916 - 108,709,540 (+)NCBIGRCm37mm9NCBIm37
MGSCv365108,509,199 - 108,520,823 (+)NCBImm8
Celera5105,388,795 - 105,400,436 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map552.82NCBI
Dr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554231,262,633 - 1,281,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554231,262,633 - 1,281,870 (-)NCBIChiLan1.0ChiLan1.0
DR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1194,746,109 - 94,762,736 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,746,109 - 94,762,736 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0196,014,758 - 96,031,402 (+)NCBIMhudiblu_PPA_v0panPan3
DR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,687,581 - 55,717,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl655,693,752 - 55,716,516 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha658,394,802 - 58,423,443 (-)NCBI
ROS_Cfam_1.0656,062,710 - 56,091,972 (-)NCBI
UMICH_Zoey_3.1655,742,084 - 55,770,728 (-)NCBI
UNSW_CanFamBas_1.0655,726,996 - 55,756,232 (-)NCBI
UU_Cfam_GSD_1.0656,180,439 - 56,209,096 (-)NCBI
Dr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,094,464 - 103,112,245 (+)NCBI
SpeTri2.0NW_0049365375,835,774 - 5,853,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,815,456 - 123,835,826 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,815,088 - 123,835,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,471,129 - 135,491,365 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,873,024 - 39,890,090 (-)NCBI
ChlSab1.1 Ensembl2039,870,814 - 39,890,106 (-)Ensembl
Vero_WHO_p1.0NW_02366603378,142,864 - 78,159,920 (+)NCBI
Dr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247424,263,288 - 4,282,097 (-)NCBI

Position Markers
RH131134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,458,343 - 1,458,530 (+)MAPPER
Rnor_6.0142,463,772 - 2,463,958NCBIRnor6.0
Rnor_6.0141,621,146 - 1,621,332NCBIRnor6.0
Rnor_5.0142,462,700 - 2,462,886UniSTSRnor5.0
Rnor_5.0141,616,377 - 1,616,563UniSTSRnor5.0
RGSC_v3.4142,006,059 - 2,006,245UniSTSRGSC3.4
Celera141,480,161 - 1,480,347UniSTS
RH 3.4 Map1431.9UniSTS
Cytogenetic Map14p22UniSTS
AI179296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,459,971 - 1,460,066 (+)MAPPER
Rnor_6.0142,465,400 - 2,465,494NCBIRnor6.0
Rnor_6.0141,622,774 - 1,622,868NCBIRnor6.0
Rnor_5.0142,464,328 - 2,464,422UniSTSRnor5.0
Rnor_5.0141,618,005 - 1,618,099UniSTSRnor5.0
RGSC_v3.4142,007,687 - 2,007,781UniSTSRGSC3.4
Celera141,481,789 - 1,481,883UniSTS
RH 3.4 Map1425.3UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14222782512680613Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14222782519230541Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:653
Count of miRNA genes:294
Interacting mature miRNAs:382
Transcripts:ENSRNOT00000000080
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 22 23 11 11 11 61 17 39 6
Below cutoff 3 19 33 29 8 29 8 10 12 17 3 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000080   ⟹   ENSRNOP00000000080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,621,026 - 1,632,378 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074874   ⟹   ENSRNOP00000064336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl142,463,643 - 2,474,780 (-)Ensembl
RefSeq Acc Id: NM_001011914   ⟹   NP_001011914
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,458,223 - 1,469,578 (-)NCBI
Rnor_6.0142,463,651 - 2,475,004 (-)NCBI
Rnor_5.0142,462,579 - 2,473,932 (-)NCBI
RGSC_v3.4142,005,938 - 2,017,291 (-)RGD
Celera141,480,040 - 1,491,393 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011914 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83822 (Get FASTA)   NCBI Sequence Viewer  
  EDL84000 (Get FASTA)   NCBI Sequence Viewer  
  Q5XI68 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001011914   ⟸   NM_001011914
- UniProtKB: Q5XI68 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064336   ⟸   ENSRNOT00000074874
RefSeq Acc Id: ENSRNOP00000000080   ⟸   ENSRNOT00000000080
Protein Domains
Histone-fold

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305201 AgrOrtholog
  RGD:6499394 AgrOrtholog
Ensembl Genes ENSRNOG00000000070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000048308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000000080 UniProtKB/Swiss-Prot
  ENSRNOP00000064336 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000080 UniProtKB/Swiss-Prot
  ENSRNOT00000074874 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111461 IMAGE-MGC_LOAD
InterPro CBFA_NFYB_domain UniProtKB/Swiss-Prot
  Histone-fold UniProtKB/Swiss-Prot
  Ncb2 UniProtKB/Swiss-Prot
KEGG Report rno:100910207 UniProtKB/Swiss-Prot
  rno:289881 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94897 IMAGE-MGC_LOAD
NCBI Gene 289881 ENTREZGENE
PANTHER PTHR46138 UniProtKB/Swiss-Prot
Pfam CBFD_NFYB_HMF UniProtKB/Swiss-Prot
PhenoGen Dr1 PhenoGen
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniProt NC2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dr1  down-regulator of transcription 1  LOC100910207  protein Dr1-like  Data Merged 737654 PROVISIONAL
2015-08-19 Dr1  down-regulator of transcription 1  Dr1  down-regulator of transcription 1, TBP-binding (negative cofactor 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-04 Dr1  down-regulator of transcription 1, TBP-binding (negative cofactor 2)  Dr1  down-regulator of transcription 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910207  protein Dr1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Dr1  down-regulator of transcription 1  Dr1_predicted  down-regulator of transcription 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dr1_predicted  down-regulator of transcription 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED