Mob1b (MOB kinase activator 1B) - Rat Genome Database

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Gene: Mob1b (MOB kinase activator 1B) Rattus norvegicus
Analyze
Symbol: Mob1b
Name: MOB kinase activator 1B
RGD ID: 1305114
Description: Predicted to enable kinase binding activity and protein kinase activator activity. Predicted to be involved in hippo signaling; positive regulation of protein phosphorylation; and regulation of protein autophosphorylation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB1B (MOB kinase activator 1B); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360920; MOB1, Mps One Binder kinase activator-like 1A; MOB1, Mps One Binder kinase activator-like 1A (yeast); Mobkl1a; mps one binder kinase activator-like 1A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21419,333,058 - 19,365,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,332,459 - 19,365,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,322,781 - 19,355,522 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01420,641,644 - 20,674,385 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01419,344,018 - 19,376,773 (-)NCBIRnor_WKY
Rnor_6.01420,960,052 - 20,992,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,960,052 - 20,992,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,870,121 - 20,903,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,911,418 - 20,944,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,918,734 - 20,944,103 (-)NCBI
Celera1418,672,400 - 18,705,217 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15067004   PMID:15197186   PMID:19739119   PMID:20458337   PMID:32057365  


Genomics

Comparative Map Data
Mob1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21419,333,058 - 19,365,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,332,459 - 19,365,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,322,781 - 19,355,522 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01420,641,644 - 20,674,385 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01419,344,018 - 19,376,773 (-)NCBIRnor_WKY
Rnor_6.01420,960,052 - 20,992,753 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,960,052 - 20,992,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,870,121 - 20,903,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,911,418 - 20,944,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,918,734 - 20,944,103 (-)NCBI
Celera1418,672,400 - 18,705,217 (-)NCBICelera
Cytogenetic Map14p22NCBI
MOB1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,901,851 - 70,988,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl470,902,326 - 71,022,449 (+)EnsemblGRCh38hg38GRCh38
GRCh37471,768,086 - 71,853,885 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,986,928 - 72,072,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 34472,133,098 - 72,218,926NCBI
Celera469,125,042 - 69,210,916 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,573,701 - 67,659,043 (+)NCBIHuRef
CHM1_1471,803,992 - 71,889,766 (+)NCBICHM1_1
T2T-CHM13v2.0474,244,807 - 74,330,605 (+)NCBIT2T-CHM13v2.0
Mob1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,868,730 - 88,906,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,868,714 - 88,912,079 (+)EnsemblGRCm39 Ensembl
GRCm38588,720,871 - 88,758,455 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,720,855 - 88,764,220 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,149,896 - 89,187,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36589,795,458 - 89,832,550 (+)NCBIMGSCv36mm8
Celera586,870,214 - 86,907,770 (+)NCBICelera
Cytogenetic Map5E1NCBI
Mob1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,077,768 - 2,092,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554472,077,768 - 2,141,373 (-)NCBIChiLan1.0ChiLan1.0
MOB1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1459,579,790 - 59,664,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl459,585,888 - 59,664,711 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0453,236,077 - 53,321,548 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MOB1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11360,145,168 - 60,197,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1360,145,366 - 60,195,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1359,879,300 - 59,935,300 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01360,950,317 - 61,006,877 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,950,396 - 61,006,872 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11360,565,698 - 60,622,147 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01360,057,229 - 60,113,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01361,204,611 - 61,261,088 (+)NCBIUU_Cfam_GSD_1.0
Mob1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,394,707 - 15,463,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365983,849,415 - 3,915,758 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365983,846,735 - 3,915,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOB1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl867,648,042 - 67,702,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1867,647,862 - 67,702,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2871,555,822 - 71,606,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOB1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1719,418,464 - 19,493,969 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl719,418,548 - 19,491,465 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660843,364,295 - 3,448,099 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mob1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248902,252,580 - 2,331,868 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mob1b
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:164
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000014650
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat

Markers in Region
BE096355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21419,341,322 - 19,341,506 (+)MAPPERmRatBN7.2
Rnor_6.01420,968,317 - 20,968,500NCBIRnor6.0
Rnor_5.01420,878,386 - 20,878,569UniSTSRnor5.0
RGSC_v3.41420,919,683 - 20,919,866UniSTSRGSC3.4
Celera1418,680,671 - 18,680,854UniSTS
RH 3.4 Map14284.8UniSTS
Cytogenetic Map14p22UniSTS
RH133241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21419,332,594 - 19,332,792 (+)MAPPERmRatBN7.2
Rnor_6.01420,959,589 - 20,959,786NCBIRnor6.0
Rnor_5.01420,869,658 - 20,869,855UniSTSRnor5.0
RGSC_v3.41420,910,955 - 20,911,152UniSTSRGSC3.4
Celera1418,671,937 - 18,672,134UniSTS
RH 3.4 Map14284.5UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 40 50 34 18 34 5 5 74 34 36 11 5
Low 1 2 7 7 1 7 3 6 1 5 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014650   ⟹   ENSRNOP00000014650
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1419,333,058 - 19,345,365 (-)Ensembl
Rnor_6.0 Ensembl1420,960,052 - 20,992,753 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104310   ⟹   ENSRNOP00000077350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1419,333,058 - 19,345,705 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114823   ⟹   ENSRNOP00000088852
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1419,332,459 - 19,365,845 (-)Ensembl
RefSeq Acc Id: NM_001108357   ⟹   NP_001101827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21419,333,058 - 19,365,845 (-)NCBI
Rnor_6.01420,960,052 - 20,992,753 (-)NCBI
Rnor_5.01420,870,121 - 20,903,365 (-)NCBI
RGSC_v3.41420,911,418 - 20,944,224 (-)RGD
Celera1418,672,400 - 18,705,217 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101827 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88528 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101827   ⟸   NM_001108357
- UniProtKB: D4A1V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014650   ⟸   ENSRNOT00000014650
RefSeq Acc Id: ENSRNOP00000088852   ⟸   ENSRNOT00000114823
RefSeq Acc Id: ENSRNOP00000077350   ⟸   ENSRNOT00000104310

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1V7-F1-model_v2 AlphaFold D4A1V7 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699239
Promoter ID:EPDNEW_R9764
Type:initiation region
Name:Mob1b_1
Description:MOB kinase activator 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01420,992,721 - 20,992,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305114 AgrOrtholog
BioCyc Gene G2FUF-16167 BioCyc
Ensembl Genes ENSRNOG00000010996 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014650 ENTREZGENE
  ENSRNOP00000014650.6 UniProtKB/TrEMBL
  ENSRNOP00000077350.1 UniProtKB/TrEMBL
  ENSRNOP00000088852.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014650 ENTREZGENE
  ENSRNOT00000014650.6 UniProtKB/TrEMBL
  ENSRNOT00000104310.1 UniProtKB/TrEMBL
  ENSRNOT00000114823.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.30 UniProtKB/TrEMBL
InterPro Mob1_phocein UniProtKB/TrEMBL
  MOB_kinase_act_sf UniProtKB/TrEMBL
KEGG Report rno:360920 UniProtKB/TrEMBL
NCBI Gene 360920 ENTREZGENE
PANTHER Mob1_phocein UniProtKB/TrEMBL
Pfam Mob1_phocein UniProtKB/TrEMBL
PhenoGen Mob1b PhenoGen
SMART Mob1_phocein UniProtKB/TrEMBL
Superfamily-SCOP Mob1_phocein UniProtKB/TrEMBL
UniProt A0A8I5YCB8_RAT UniProtKB/TrEMBL
  A0A8I6AAQ1_RAT UniProtKB/TrEMBL
  D4A1V7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Mob1b  MOB kinase activator 1B  Mobkl1a  MOB1, Mps One Binder kinase activator-like 1A (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mobkl1a  MOB1, Mps One Binder kinase activator-like 1A (yeast)   Mobkl1a_predicted  MOB1, Mps One Binder kinase activator-like 1A (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mobkl1a_predicted  MOB1, Mps One Binder kinase activator-like 1A (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED