Kbtbd6 (kelch repeat and BTB domain containing 6) - Rat Genome Database

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Gene: Kbtbd6 (kelch repeat and BTB domain containing 6) Rattus norvegicus
Analyze
Symbol: Kbtbd6
Name: kelch repeat and BTB domain containing 6
RGD ID: 1305086
Description: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to several human genes including KBTBD6 (kelch repeat and BTB domain containing 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch repeat and BTB (POZ) domain containing 6; kelch repeat and BTB domain-containing protein 6; LOC306073
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81561,257,360 - 61,259,117 (+)NCBIGRCr8
mRatBN7.21554,848,285 - 54,850,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1554,848,446 - 54,850,453 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1558,981,738 - 58,983,495 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01560,100,130 - 60,101,887 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01556,925,008 - 56,926,765 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01561,731,574 - 61,733,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1561,731,735 - 61,733,742 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01565,395,106 - 65,396,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41561,501,576 - 61,503,070 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11561,517,355 - 61,518,847 (+)NCBI
Celera1554,430,259 - 54,432,016 (+)NCBICelera
Cytogenetic Map15q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Kbtbd6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81561,257,360 - 61,259,117 (+)NCBIGRCr8
mRatBN7.21554,848,285 - 54,850,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1554,848,446 - 54,850,453 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1558,981,738 - 58,983,495 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01560,100,130 - 60,101,887 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01556,925,008 - 56,926,765 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01561,731,574 - 61,733,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1561,731,735 - 61,733,742 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01565,395,106 - 65,396,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41561,501,576 - 61,503,070 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11561,517,355 - 61,518,847 (+)NCBI
Celera1554,430,259 - 54,432,016 (+)NCBICelera
Cytogenetic Map15q12NCBI
KBTBD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381341,127,569 - 41,132,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1341,127,569 - 41,132,802 (-)EnsemblGRCh38hg38GRCh38
GRCh371341,701,705 - 41,706,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,599,709 - 40,604,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 341340,599,708 - 40,604,936NCBI
Celera1322,759,139 - 22,764,364 (-)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1322,501,835 - 22,507,060 (-)NCBIHuRef
CHM1_11341,669,521 - 41,674,743 (-)NCBICHM1_1
T2T-CHM13v2.01340,346,698 - 40,351,926 (-)NCBIT2T-CHM13v2.0
Kbtbd6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391479,689,275 - 79,692,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1479,689,275 - 79,692,258 (+)EnsemblGRCm39 Ensembl
GRCm381479,451,835 - 79,454,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1479,451,835 - 79,454,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv371479,851,642 - 79,854,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361478,185,990 - 78,188,971 (+)NCBIMGSCv36mm8
Celera1476,951,762 - 76,954,813 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1442.66NCBI
KBTBD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21440,644,847 - 40,650,291 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11331,748,565 - 31,754,007 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01322,329,845 - 22,335,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11340,918,892 - 40,924,098 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1340,921,761 - 40,923,813 (-)Ensemblpanpan1.1panPan2
KBTBD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1229,466,707 - 9,478,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl229,467,020 - 9,469,152 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha229,462,763 - 9,475,449 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0229,692,726 - 9,697,554 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl229,693,111 - 9,695,252 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1229,388,031 - 9,400,741 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0229,437,706 - 9,450,363 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,452,135 - 9,464,805 (+)NCBIUU_Cfam_GSD_1.0
LOC100154105
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1125,643,709 - 25,710,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11125,704,933 - 25,710,994 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,509,103 - 26,512,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KBTBD6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1319,388,132 - 19,391,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl319,389,455 - 19,391,482 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605724,844,640 - 24,849,745 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Kbtbd6
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:101
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000015517, ENSRNOT00000071455
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)155284790873690657Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 10 8 3 8 3 70 14 39 9
Below cutoff 3 44 63 52 10 52 8 10 30 30 23 2 8

Sequence


RefSeq Acc Id: ENSRNOT00000015517   ⟹   ENSRNOP00000064349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1554,848,446 - 54,850,453 (+)Ensembl
Rnor_6.0 Ensembl1561,731,735 - 61,733,742 (+)Ensembl
RefSeq Acc Id: NM_001012045   ⟹   NP_001012045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81561,257,360 - 61,259,117 (+)NCBI
mRatBN7.21554,848,285 - 54,850,042 (+)NCBI
Rnor_6.01561,731,574 - 61,733,331 (+)NCBI
Rnor_5.01565,395,106 - 65,396,863 (+)NCBI
RGSC_v3.41561,501,576 - 61,503,070 (+)RGD
Celera1554,430,259 - 54,432,016 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86326 (Get FASTA)   NCBI Sequence Viewer  
  EDM02356 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064349
  ENSRNOP00000064349.1
RefSeq Acc Id: NP_001012045   ⟸   NM_001012045
- UniProtKB: M0R4Q5 (UniProtKB/TrEMBL),   A6HTZ3 (UniProtKB/TrEMBL),   Q5U218 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064349   ⟸   ENSRNOT00000015517
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4Q5-F1-model_v2 AlphaFold M0R4Q5 1-489 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699847
Promoter ID:EPDNEW_R10371
Type:multiple initiation site
Name:Kbtbd6_2
Description:kelch repeat and BTB domain containing 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10370  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01561,731,718 - 61,731,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305086 AgrOrtholog
BioCyc Gene G2FUF-12992 BioCyc
Ensembl Genes ENSRNOG00000011657 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015517 ENTREZGENE
  ENSRNOT00000015517.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114652 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  KBTBD6_7_BACK UniProtKB/TrEMBL
  KBTBD6_7_BTB_POZ UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:306073 UniProtKB/TrEMBL
MGC_CLONE MGC:105795 IMAGE-MGC_LOAD
NCBI Gene 306073 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  KELCH REPEAT AND BTB (POZ) DOMAIN-CONTAINING 6 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Kbtbd6 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011657 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A6HTZ3 ENTREZGENE, UniProtKB/TrEMBL
  M0R4Q5 ENTREZGENE, UniProtKB/TrEMBL
  Q5U218 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kbtbd6  kelch repeat and BTB domain containing 6  Kbtbd6  kelch repeat and BTB (POZ) domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-18 Kbtbd6  kelch repeat and BTB (POZ) domain containing 6  Kbtbd7  kelch repeat and BTB (POZ) domain containing 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Kbtbd7  kelch repeat and BTB (POZ) domain containing 7  Kbtbd7_predicted  kelch repeat and BTB (POZ) domain containing 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Kbtbd7_predicted  kelch repeat and BTB (POZ) domain containing 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED