Nek4 (NIMA-related kinase 4) - Rat Genome Database

Name: Nek4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Nek4 (NIMA-related kinase 4) Rattus norvegicus

Analyze

Symbol:

Nek4

Name:

NIMA-related kinase 4

RGD ID:

1304995

Description:

Predicted to enable manganese ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of DNA-templated transcription; protein phosphorylation; and regulation of cellular senescence. Located in ciliary plasm; ciliary transition zone; and cytoskeleton. Orthologous to human NEK4 (NIMA related kinase 4); INTERACTS WITH 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC306252; NIMA (never in mitosis gene a)-related expressed kinase 4; NIMA (never in mitosis gene a)-related kinase 4; serine/threonine-protein kinase Nek4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEK4 (NIMA related kinase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nek4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEK4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEK4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nek4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEK4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEK4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nek4 (NIMA related kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NEK4 (NIMA related kinase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nek4 (NIMA (never in mitosis gene a)-related expressed kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nek4 (NIMA-related kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nek4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	6,144,900 - 6,185,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,144,959 - 6,188,932 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	6,156,495 - 6,197,248 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,301,957 - 7,342,710 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	16	6,163,758 - 6,204,437 (+)	NCBI	Rnor_WKY
Rnor_6.0	16	7,035,002 - 7,080,272 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	7,035,068 - 7,075,554 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,961,142 - 7,009,810 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	6,386,850 - 6,422,465 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	6,386,924 - 6,422,453 (+)	NCBI
Celera	16	9,003,955 - 9,044,746 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ciliopathy (ISO)

congenital disorder of glycosylation In (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

CGP 52608 (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

indole-3-methanol (EXP)

inulin (ISO)

L-methionine (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IBA,ISO)

mitotic cell cycle (ISO)

positive regulation of DNA-templated transcription (ISO)

protein phosphorylation (ISO)

regulation of cellular senescence (ISO)

Cellular Component

ciliary basal body (IDA)

ciliary plasm (IDA)

ciliary rootlet (IDA)

ciliary transition zone (IDA)

cytoplasm (IBA,ISO)

cytosol (ISO)

Molecular Function

ATP binding (IEA)

manganese ion binding (ISO)

protein serine/threonine kinase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.	Coene KL, etal., Hum Mol Genet. 2011 Sep 15;20(18):3592-605. doi: 10.1093/hmg/ddr280. Epub 2011 Jun 17.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10529384	PMID:12477932	PMID:22851694

Genomics

Comparative Map Data

Nek4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	6,144,900 - 6,185,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,144,959 - 6,188,932 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	6,156,495 - 6,197,248 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,301,957 - 7,342,710 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	16	6,163,758 - 6,204,437 (+)	NCBI	Rnor_WKY
Rnor_6.0	16	7,035,002 - 7,080,272 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	7,035,068 - 7,075,554 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,961,142 - 7,009,810 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	6,386,850 - 6,422,465 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	6,386,924 - 6,422,453 (+)	NCBI
Celera	16	9,003,955 - 9,044,746 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

NEK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	52,708,444 - 52,770,940 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	52,708,444 - 52,770,946 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	52,742,460 - 52,804,956 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,719,840 - 52,779,991 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	52,719,841 - 52,779,979	NCBI
Celera	3	52,723,506 - 52,783,686 (-)	NCBI		Celera
Cytogenetic Map	3	p21.1	NCBI
HuRef	3	52,806,323 - 52,866,636 (-)	NCBI		HuRef
CHM1_1	3	52,696,967 - 52,757,147 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	52,741,355 - 52,803,847 (-)	NCBI		T2T-CHM13v2.0

Nek4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	30,673,334 - 30,710,778 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	30,673,334 - 30,710,778 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	30,951,377 - 30,988,821 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	30,951,377 - 30,988,821 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	31,764,674 - 31,800,587 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	29,780,497 - 29,816,410 (+)	NCBI		MGSCv36	mm8
Celera	14	27,208,772 - 27,245,215 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI

Nek4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	2,696,493 - 2,733,392 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	2,695,674 - 2,733,204 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	52,707,159 - 52,770,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	52,649,280 - 52,712,645 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	53,877,257 - 53,938,520 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	53,878,760 - 53,938,520 (-)	Ensembl	panpan1.1		panPan2

NEK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,056,852 - 37,091,977 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	37,056,754 - 37,092,686 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	37,039,095 - 37,073,987 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	37,407,881 - 37,442,744 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	37,407,885 - 37,440,616 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	36,771,452 - 36,806,315 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	37,179,859 - 37,214,937 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	37,457,447 - 37,492,395 (+)	NCBI		UU_Cfam_GSD_1.0

Nek4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	170,361,288 - 170,389,366 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	3,499,754 - 3,528,329 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	3,499,858 - 3,527,918 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,841,366 - 34,896,565 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	34,844,972 - 34,909,028 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	38,065,216 - 38,081,875 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	14,083,583 - 14,152,775 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	14,121,073 - 14,152,547 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	152,745,104 - 152,816,427 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nek4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	4,453,379 - 4,502,579 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624822	4,454,040 - 4,500,031 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nek4
89 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	13
Count of miRNA genes:	13
Interacting mature miRNAs:	13
Transcripts:	ENSRNOT00000024296
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat

Markers in Region

RH132166

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	6,167,122 - 6,167,314 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	7,057,307 - 7,057,498	NCBI	Rnor6.0
Rnor_5.0	16	6,986,189 - 6,986,380	UniSTS	Rnor5.0
RGSC_v3.4	16	6,404,214 - 6,404,405	UniSTS	RGSC3.4
Celera	16	9,021,946 - 9,022,137	UniSTS
Cytogenetic Map	16	p16	UniSTS

BE118756

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	6,185,128 - 6,185,287 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	7,075,311 - 7,075,469	NCBI	Rnor6.0
Rnor_5.0	16	7,003,894 - 7,004,052	UniSTS	Rnor5.0
RGSC_v3.4	16	6,422,218 - 6,422,376	UniSTS	RGSC3.4
Celera	16	9,004,044 - 9,004,202	UniSTS
RH 3.4 Map	16	43.4	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			13	4	3	4			72	26	41	11
Low	3	43	44	37	16	37	8	11	2	9			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024296 ⟹ ENSRNOP00000024296

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,144,971 - 6,185,376 (+)	Ensembl
Rnor_6.0 Ensembl	16	7,035,068 - 7,075,554 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084977 ⟹ ENSRNOP00000070463

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,144,959 - 6,155,034 (+)	Ensembl
Rnor_6.0 Ensembl	16	7,035,241 - 7,045,218 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095362 ⟹ ENSRNOP00000078317

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,144,971 - 6,185,376 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099879 ⟹ ENSRNOP00000078707

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,144,959 - 6,178,939 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117461 ⟹ ENSRNOP00000086129

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,144,959 - 6,188,932 (+)	Ensembl

RefSeq Acc Id:

NM_001013134 ⟹ NP_001013152

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	6,144,971 - 6,185,376 (+)	NCBI
Rnor_6.0	16	7,035,103 - 7,075,558 (+)	NCBI
Rnor_5.0	16	6,961,142 - 7,009,810 (+)	NCBI
RGSC_v3.4	16	6,386,850 - 6,422,465 (+)	RGD
Celera	16	9,003,955 - 9,044,746 (-)	RGD

Sequence:

show sequence

TGGGCCGGGCCTGGAAGCTCCTACACCGGGTGGGCCGCGATTATGGACGACTTCACTTCCAGTC
GGGCATGAGCGGGGCCTCCCGCTGCCTTATGCGCCGCTACCGCAGCTTCCCGACTGTAGGCCTC
CTTCGGGAACATGCCCCAAGCCGCATACTGTTACTTGCGGGTCGTGGGCAGGGGTAGTTACGGG
GAGGTGACGCTCGTGAAGCATCGGCGGGACGGCAAGCAGTATGTCATCAAAAAGCTGAACCTCC
GGAATGCCTCCAGCCGGGAGCGTCGAGCGGCAGAGCAGGAGGCTCAGCTCCTGTCTCAGTTGAA
GCACCCCAACATTGTCACCTACAAAGAGTCATGGGAGGGCGGAGACGGTCTGCTCTACATCGTC
ATGGGCTTCTGCGAAGGAGGCGATCTGTACCGGAAGCTCAAGGAGCAGAAGGGGCAGCTTCTGC
CTGAGAGTCAGGTGGTGGAGTGGTTTGTCCAGATCGCCATGGCCTTGCAGTACTTACATGAGAA
GCACATCCTTCATCGAGATCTGAAAACTCAGAATGTCTTCCTAACAAGAACAAACATCATCAAA
GTAGGTGACCTAGGCATTGCCCGAGTGTTGGAGAATCACAGTGACATGGCGAGCACCCTCATTG
GCACACCCTATTACATGAGTCCTGAGCTGTTCTCCAACAAACCCTACAACTATAAGTCGGATGT
TTGGGCTTTGGGATGCTGCGTGTATGAAATGGCCACCCTGAAGCATGCTTTTAATGCAAAAGAC
ATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGTTGCCACCAATGCCAAAAGTTTACAGTG
CGGAGCTGGCAGAGCTGATAAGAACCATGTTGAGCAGGAGACCTGAGGAGAGGCCCTCTGTGCG
GAGCATCCTGCGGCAGCCCTACATAAAACACCACATCTCCTTGTTCTTGGAGGCCACCAAGGCG
AAAACTTCCAAAAATAATGTTAAAAACTGTGACTCCAGAGCCAAACCCGTTGCTGCTGTAGTTT
CCAGAAAGGAAGAACCAAATCATGAAATGATTCCCTACCAGCCACGCTCTTCTGAGGGCTCCGC
TGTACATGCCACGGGTGAAGATAAATGTCTGTCCCAAGAAAAACCAGTGGACATTGGTCCCTTG
AAATCACCTGCTAGTCTCGAAGGCCACACTGGCAAACAAGACATGAACAGGACTGCAGAGTCGT
GTGCCACAGTCAGTAGGATAAATATCGATATCTTACCTGCAGAAAGGAGGGACTCAGCAAAAGA
TGGCACAGTTGAGGAGGGCCGACCACAGCACGTGGATGCTTCTAATGAAGTAGACCGTCAATGC
AGTATTTCTCAAGAGAAGGAGAGGCTACAGGGCAACAGCAAGTCTAGTGATCAGCCGGAAAATC
TCCTTCCCAGATGGTCCTCTGGTGGTGGTGATGGGGAAGGGAATGAACTGGTGAAGCTGTTGTA
CTCCTCGGGTAAAGACCAAAAGCCACAGCAGGATCAAGTTACTAGCGGGTGTATTCTAGAAGAT
CAGGACAGCATCCACCCAAGACTGCAGCCGCACAGCTCTGTATCTGAACCTTCTTTGTCCCGGC
AGCGAAGGCAGAGAAAAAGGGAACAGACGAACCACGGTCGGGCAAAGAGCCAGCTCCAAGAATC
ACCCCCTCGTCTTGTGCCTTCTCACCCTGATACTGGGAAAGCAGATATCATAAGTACACAGCAA
AGTGATGGAAACCAAAGTGGACCTGTGGCTAGGTCTGTGAATGGTTCAAGGTCTAGTTCGACAG
CGTCATCAAAGGATCGGCCATTATCAGCCAGAGAGAGGAGACGACTAAAGCAGTCGCAGGAAGA
GATGCTCCCCTCAGGCCCTGCAGTTCAGAGAACTCCAAGTTCAGTAGAGCCAGTGAAACCACAG
GAAGAAGACCAACCCATCCCTGCCCAACGATTCTCTTCTGACTGCAACATCACTCAGGTGAATC
CCACACTCCTGAGGGAAAAGAAGAGACTGATCCATGGACTGTCTGAGGATGAGTTAAGTTCTTC
CACAAGCTCAACTGATAAATCAGATGGGGATTCCAGGGAGGGGAAAAGTCATACAAATGAAATG
AGAGACTTGGTGCAGCTGATGACTCAGACTCTGAGGCTGGAAGCTAAAGAGAGCTGTGAAGATC
TTCATGTACCAAACCCAGGGTCAGAGTTCAGACTTCATCGCAAGTATCGAGACACGCTGGTGCT
CCACGGCAAGGCTGCGGAAGAGGGGGAGCCCCCCTGTGTGGAGTTACCTCCAGGTATCACACCA
GGTTCTGAAAAGATCAGGAGAATAGTTGAAGTCTTAAGAGCTGATGTGATCCAGGGCCTGGGGG
TTCAGCTTTTAGAGCAGGTGTATGATCTTTTGGAGGAGGAAGATGAGTTGGAGAGAGAGGCACG
ATTACAGGAGCACATGGGAGACAAGTATACAACTTACAGTGTGAAAGCTCGCCAGTTGAAGTTT
TTTGAAGAAAATGTGAGTTTTTGAGGTTTGTTCTAACATGCTGCCAGAACTAAAGATCTATTTT
CAAAGGTTTTTTCATCTTAAAAAACCTGTTTCAGTCATTTGGAGGCTGACTACCATCCTTTGAT
ATCGCTTGGAGTCTTCTTACCATAAAAAACTGAAGAGTTTGAAACAATATGAAACAAGTTCACA
AAAGAAAAAAAACTTTGAATATCATGTTTATGAG

hide sequence

RefSeq Acc Id:

XM_039094443 ⟹ XP_038950371

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	6,144,900 - 6,178,398 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013152	(Get FASTA)	NCBI Sequence Viewer
	XP_038950371	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88323	(Get FASTA)	NCBI Sequence Viewer
	EDL88973	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001013152 ⟸ NM_001013134

- UniProtKB:

D3ZDV9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPN
IVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHIL
HRDLKTQNVFLTRTNIIKVGDLGIARVLENHSDMASTLIGTPYYMSPELFSNKPYNYKSDVWAL
GCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSIL
RQPYIKHHISLFLEATKAKTSKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHA
TGEDKCLSQEKPVDIGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTV
EEGRPQHVDASNEVDRQCSISQEKERLQGNSKSSDQPENLLPRWSSGGGDGEGNELVKLLYSSG
KDQKPQQDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKSQLQESPPR
LVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRRLKQSQEEMLP
SGPAVQRTPSSVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREKKRLIHGLSEDELSSSTSS
TDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHVPNPGSEFRLHRKYRDTLVLHGK
AAEEGEPPCVELPPGITPGSEKIRRIVEVLRADVIQGLGVQLLEQVYDLLEEEDELEREARLQE
HMGDKYTTYSVKARQLKFFEENVSF

hide sequence

RefSeq Acc Id:

ENSRNOP00000070463 ⟸ ENSRNOT00000084977

RefSeq Acc Id:

ENSRNOP00000024296 ⟸ ENSRNOT00000024296

RefSeq Acc Id:	XP_038950371 ⟸ XM_039094443
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000078707 ⟸ ENSRNOT00000099879

RefSeq Acc Id:

ENSRNOP00000086129 ⟸ ENSRNOT00000117461

RefSeq Acc Id:

ENSRNOP00000078317 ⟸ ENSRNOT00000095362

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDV9-F1-model_v2	AlphaFold	D3ZDV9	1-793	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699918

Promoter ID:

EPDNEW_R10442

Type:

multiple initiation site

Name:

Nek4_1

Description:

NIMA-related kinase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	7,035,077 - 7,035,137	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304995	AgrOrtholog
BioCyc Gene	G2FUF-12173	BioCyc
Ensembl Genes	ENSRNOG00000017997	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024296	ENTREZGENE
	ENSRNOP00000024296.6	UniProtKB/TrEMBL
	ENSRNOP00000070463.1	UniProtKB/TrEMBL
	ENSRNOP00000078317.1	UniProtKB/TrEMBL
	ENSRNOP00000078707.1	UniProtKB/TrEMBL
	ENSRNOP00000086129.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024296	ENTREZGENE
	ENSRNOT00000024296.8	UniProtKB/TrEMBL
	ENSRNOT00000084977.2	UniProtKB/TrEMBL
	ENSRNOT00000095362.1	UniProtKB/TrEMBL
	ENSRNOT00000099879.1	UniProtKB/TrEMBL
	ENSRNOT00000117461.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:306252	UniProtKB/TrEMBL
NCBI Gene	306252	ENTREZGENE
PANTHER	CAMK FAMILY PROTEIN KINASE	UniProtKB/TrEMBL
	SERINE/THREONINE PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Nek4	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZKL8_RAT	UniProtKB/TrEMBL
	A0A8I5ZLB3_RAT	UniProtKB/TrEMBL
	A0A8I6A574_RAT	UniProtKB/TrEMBL
	D3ZDV9	ENTREZGENE, UniProtKB/TrEMBL
	Q5M813_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-11-21	Nek4	NIMA-related kinase 4	Nek4	NIMA (never in mitosis gene a)-related kinase 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Nek4	NIMA (never in mitosis gene a)-related kinase 4	Nek4	NIMA (never in mitosis gene a)-related expressed kinase 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Nek4	NIMA (never in mitosis gene a)-related expressed kinase 4	Nek4_predicted	NIMA (never in mitosis gene a)-related expressed kinase 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Nek4_predicted	NIMA (never in mitosis gene a)-related expressed kinase 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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