Nek4 (NIMA-related kinase 4) - Rat Genome Database

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Gene: Nek4 (NIMA-related kinase 4) Rattus norvegicus
Analyze
Symbol: Nek4
Name: NIMA-related kinase 4
RGD ID: 1304995
Description: Predicted to enable manganese ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including DNA damage response; positive regulation of DNA-templated transcription; and regulation of cellular senescence. Located in ciliary plasm; ciliary transition zone; and cytoskeleton. Orthologous to human NEK4 (NIMA related kinase 4); INTERACTS WITH 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC306252; NIMA (never in mitosis gene a)-related expressed kinase 4; NIMA (never in mitosis gene a)-related kinase 4; serine/threonine-protein kinase Nek4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,151,292 - 6,200,280 (+)NCBIGRCr8
mRatBN7.2166,144,900 - 6,185,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,144,959 - 6,188,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,156,495 - 6,197,248 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,301,957 - 7,342,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,163,758 - 6,204,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,035,002 - 7,080,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,035,068 - 7,075,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,961,142 - 7,009,810 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,386,850 - 6,422,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,386,924 - 6,422,453 (+)NCBI
Celera169,003,955 - 9,044,746 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Coene KL, etal., Hum Mol Genet. 2011 Sep 15;20(18):3592-605. doi: 10.1093/hmg/ddr280. Epub 2011 Jun 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10529384   PMID:12477932   PMID:22851694  


Genomics

Comparative Map Data
Nek4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,151,292 - 6,200,280 (+)NCBIGRCr8
mRatBN7.2166,144,900 - 6,185,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,144,959 - 6,188,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,156,495 - 6,197,248 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,301,957 - 7,342,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,163,758 - 6,204,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,035,002 - 7,080,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,035,068 - 7,075,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,961,142 - 7,009,810 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,386,850 - 6,422,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,386,924 - 6,422,453 (+)NCBI
Celera169,003,955 - 9,044,746 (-)NCBICelera
Cytogenetic Map16p16NCBI
NEK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,708,444 - 52,770,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,708,444 - 52,770,946 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,742,460 - 52,804,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,719,840 - 52,779,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,719,841 - 52,779,979NCBI
Celera352,723,506 - 52,783,686 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,806,323 - 52,866,636 (-)NCBIHuRef
CHM1_1352,696,967 - 52,757,147 (-)NCBICHM1_1
T2T-CHM13v2.0352,741,355 - 52,803,847 (-)NCBIT2T-CHM13v2.0
Nek4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,673,334 - 30,710,778 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,673,334 - 30,710,778 (+)EnsemblGRCm39 Ensembl
GRCm381430,951,377 - 30,988,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,951,377 - 30,988,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,764,674 - 31,800,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,780,497 - 29,816,410 (+)NCBIMGSCv36mm8
Celera1427,208,772 - 27,245,215 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Nek4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,696,493 - 2,733,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,695,674 - 2,733,204 (-)NCBIChiLan1.0ChiLan1.0
NEK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,704,488 - 52,765,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,707,159 - 52,770,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,649,280 - 52,712,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,877,257 - 53,938,520 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,878,760 - 53,938,520 (-)Ensemblpanpan1.1panPan2
NEK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,056,852 - 37,091,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,056,754 - 37,092,686 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,039,095 - 37,073,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,407,881 - 37,442,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,407,885 - 37,440,616 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,771,452 - 36,806,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,179,859 - 37,214,937 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,457,447 - 37,492,395 (+)NCBIUU_Cfam_GSD_1.0
Nek4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,361,288 - 170,389,366 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,499,754 - 3,528,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,499,858 - 3,527,918 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,841,366 - 34,896,565 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,844,972 - 34,909,028 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,065,216 - 38,081,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,083,583 - 14,152,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,121,073 - 14,152,547 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,745,104 - 152,816,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,453,379 - 4,502,579 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,454,040 - 4,500,031 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek4
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000024296
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat

Markers in Region
RH132166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,167,122 - 6,167,314 (+)MAPPERmRatBN7.2
Rnor_6.0167,057,307 - 7,057,498NCBIRnor6.0
Rnor_5.0166,986,189 - 6,986,380UniSTSRnor5.0
RGSC_v3.4166,404,214 - 6,404,405UniSTSRGSC3.4
Celera169,021,946 - 9,022,137UniSTS
Cytogenetic Map16p16UniSTS
BE118756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,185,128 - 6,185,287 (+)MAPPERmRatBN7.2
Rnor_6.0167,075,311 - 7,075,469NCBIRnor6.0
Rnor_5.0167,003,894 - 7,004,052UniSTSRnor5.0
RGSC_v3.4166,422,218 - 6,422,376UniSTSRGSC3.4
Celera169,004,044 - 9,004,202UniSTS
RH 3.4 Map1643.4UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024296   ⟹   ENSRNOP00000024296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,144,971 - 6,185,376 (+)Ensembl
Rnor_6.0 Ensembl167,035,068 - 7,075,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084977   ⟹   ENSRNOP00000070463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,144,959 - 6,155,034 (+)Ensembl
Rnor_6.0 Ensembl167,035,241 - 7,045,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095362   ⟹   ENSRNOP00000078317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,144,971 - 6,185,376 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099879   ⟹   ENSRNOP00000078707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,144,959 - 6,178,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117461   ⟹   ENSRNOP00000086129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,144,959 - 6,188,932 (+)Ensembl
RefSeq Acc Id: NM_001013134   ⟹   NP_001013152
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,151,419 - 6,191,822 (+)NCBI
mRatBN7.2166,144,971 - 6,185,376 (+)NCBI
Rnor_6.0167,035,103 - 7,075,558 (+)NCBI
Rnor_5.0166,961,142 - 7,009,810 (+)NCBI
RGSC_v3.4166,386,850 - 6,422,465 (+)RGD
Celera169,003,955 - 9,044,746 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094443   ⟹   XP_038950371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,151,305 - 6,180,799 (+)NCBI
mRatBN7.2166,144,900 - 6,178,398 (+)NCBI
RefSeq Acc Id: XM_063275290   ⟹   XP_063131360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,151,292 - 6,200,280 (+)NCBI
RefSeq Acc Id: XM_063275291   ⟹   XP_063131361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,162,970 - 6,200,280 (+)NCBI
RefSeq Acc Id: XM_063275292   ⟹   XP_063131362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,162,971 - 6,200,280 (+)NCBI
RefSeq Acc Id: NP_001013152   ⟸   NM_001013134
- UniProtKB: D3ZDV9 (UniProtKB/TrEMBL),   A6KG16 (UniProtKB/TrEMBL),   A0A8I6A574 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070463   ⟸   ENSRNOT00000084977
Ensembl Acc Id: ENSRNOP00000024296   ⟸   ENSRNOT00000024296
RefSeq Acc Id: XP_038950371   ⟸   XM_039094443
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000078707   ⟸   ENSRNOT00000099879
Ensembl Acc Id: ENSRNOP00000086129   ⟸   ENSRNOT00000117461
Ensembl Acc Id: ENSRNOP00000078317   ⟸   ENSRNOT00000095362
RefSeq Acc Id: XP_063131360   ⟸   XM_063275290
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A574 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131361   ⟸   XM_063275291
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131362   ⟸   XM_063275292
- Peptide Label: isoform X4
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDV9-F1-model_v2 AlphaFold D3ZDV9 1-793 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699918
Promoter ID:EPDNEW_R10442
Type:multiple initiation site
Name:Nek4_1
Description:NIMA-related kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0167,035,077 - 7,035,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304995 AgrOrtholog
BioCyc Gene G2FUF-12173 BioCyc
Ensembl Genes ENSRNOG00000017997 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024296.8 UniProtKB/TrEMBL
  ENSRNOT00000084977.2 UniProtKB/TrEMBL
  ENSRNOT00000095362.1 UniProtKB/TrEMBL
  ENSRNOT00000099879.1 UniProtKB/TrEMBL
  ENSRNOT00000117461.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  NEK_Ser/Thr_kinase_NIMA UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:306252 UniProtKB/TrEMBL
NCBI Gene 306252 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nek4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017997 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZKL8_RAT UniProtKB/TrEMBL
  A0A8I5ZLB3_RAT UniProtKB/TrEMBL
  A0A8I6A574 ENTREZGENE, UniProtKB/TrEMBL
  A6KG16 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDV9 ENTREZGENE, UniProtKB/TrEMBL
  Q5M813_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Nek4  NIMA-related kinase 4  Nek4  NIMA (never in mitosis gene a)-related kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nek4  NIMA (never in mitosis gene a)-related kinase 4  Nek4  NIMA (never in mitosis gene a)-related expressed kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Nek4  NIMA (never in mitosis gene a)-related expressed kinase 4  Nek4_predicted  NIMA (never in mitosis gene a)-related expressed kinase 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Nek4_predicted  NIMA (never in mitosis gene a)-related expressed kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED