Ubtfl1 (upstream binding transcription factor like 1) - Rat Genome Database

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Gene: Ubtfl1 (upstream binding transcription factor like 1) Rattus norvegicus
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Symbol: Ubtfl1
Name: upstream binding transcription factor like 1
RGD ID: 1304745
Description: Predicted to act upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Orthologous to human UBTFL1 (upstream binding transcription factor like 1); INTERACTS WITH benzo[a]pyrene (ortholog); perfluorohexanesulfonic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC300381; RGD1304745; similar to methyl-CpG binding domain protein 3-like protein 2; Ubtfl2; upstream binding transcription factor like 2; upstream-binding factor 1-like protein 1
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8823,787,567 - 23,788,754 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl823,787,567 - 23,788,754 (-)EnsemblGRCr8
mRatBN7.2815,511,217 - 15,512,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl816,073,983 - 16,075,170 (+)EnsemblmRatBN7.2
Rnor_6.0817,561,870 - 17,563,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl817,562,026 - 17,563,062 (-)Ensemblrn6Rnor6.0
Rnor_5.0817,618,877 - 17,634,474 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4815,874,433 - 15,875,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera816,939,658 - 16,940,845 (-)NCBICelera
RGSC_v3.1815,874,432 - 15,932,549 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
Ubtfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8823,787,567 - 23,788,754 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl823,787,567 - 23,788,754 (-)EnsemblGRCr8
mRatBN7.2815,511,217 - 15,512,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl816,073,983 - 16,075,170 (+)EnsemblmRatBN7.2
Rnor_6.0817,561,870 - 17,563,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl817,562,026 - 17,563,062 (-)Ensemblrn6Rnor6.0
Rnor_5.0817,618,877 - 17,634,474 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4815,874,433 - 15,875,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera816,939,658 - 16,940,845 (-)NCBICelera
RGSC_v3.1815,874,432 - 15,932,549 (-)NCBI
Cytogenetic Map8q13NCBI
UBTFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381190,085,950 - 90,087,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1190,085,950 - 90,087,131 (+)Ensemblhg38GRCh38
GRCh371189,819,118 - 89,820,299 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361189,458,757 - 89,459,947 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1185,144,267 - 85,145,448 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,903,248 - 85,904,429 (+)NCBIHuRef
CHM1_11189,702,145 - 89,703,327 (+)NCBICHM1_1
T2T-CHM13v2.01190,006,027 - 90,007,208 (+)NCBIT2T-CHM13v2.0
Ubtfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39918,315,714 - 18,322,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl918,315,714 - 18,324,473 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38918,404,418 - 18,411,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl918,404,418 - 18,413,177 (+)Ensemblmm10GRCm38
MGSCv37918,208,862 - 18,215,946 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36918,154,820 - 18,161,904 (+)NCBIMGSCv36mm8
Celera915,688,053 - 15,695,137 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map97.04NCBI
LOC117974918
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2951,230,026 - 51,231,397 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11151,263,372 - 51,265,241 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,971,442 - 48,972,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Ubtfl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,121,221 - 2,122,460 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936933371,183 - 376,907 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBTFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1923,060,755 - 23,069,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UBTFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1181,168,060 - 81,173,080 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604344,573,493 - 44,575,528 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubtfl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845327,418 - 328,587 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624845326,830 - 328,587 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ubtfl1
3 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 1 3 4 4 3 1 3 6 2 3 25 1

Sequence


Ensembl Acc Id: ENSRNOT00000092214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl816,073,983 - 16,075,170 (+)Ensembl
Rnor_6.0 Ensembl817,562,026 - 17,563,062 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101632   ⟹   ENSRNOP00000083146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl823,787,567 - 23,788,754 (-)Ensembl
RefSeq Acc Id: NM_001421232   ⟹   NP_001408161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8823,787,567 - 23,788,754 (-)NCBI
mRatBN7.2815,511,217 - 15,512,404 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001408161 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083146
RefSeq Acc Id: NP_001408161   ⟸   NM_001421232
Ensembl Acc Id: ENSRNOP00000083146   ⟸   ENSRNOT00000101632

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304745 AgrOrtholog
BioCyc Gene G2FUF-31602 BioCyc
Ensembl Genes ENSRNOG00000052334 Ensembl
  ENSRNOG00000079909 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101632 ENTREZGENE
NCBI Gene 300381 ENTREZGENE
PhenoGen Ubtfl1 PhenoGen
RatGTEx ENSRNOG00000052334 RatGTEx
  ENSRNOG00000079909 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-15 Ubtfl1  upstream binding transcription factor like 1  Ubtfl1b  upstream binding transcription factor like 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-05-15 Ubtfl1b  upstream binding transcription factor like 1B  Ubtfl2  upstream binding transcription factor like 2  Name and Symbol changed 629549 APPROVED
2023-05-12 Ubtfl2  upstream binding transcription factor like 2  RGD1304745  similar to methyl-CpG binding domain protein 3-like protein 2  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1304745  similar to methyl-CpG binding domain protein 3-like protein 2   RGD1304745_predicted  similar to methyl-CpG binding domain protein 3-like protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1304745_predicted  similar to methyl-CpG binding domain protein 3-like protein 2 (predicted)  LOC300381_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC300381_predicted  similar to methyl-CpG binding domain protein 3-like protein 2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL