Asxl2 (ASXL transcriptional regulator 2) - Rat Genome Database
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Gene: Asxl2 (ASXL transcriptional regulator 2) Rattus norvegicus
Analyze
Symbol: Asxl2
Name: ASXL transcriptional regulator 2
RGD ID: 1304710
Description: Predicted to have chromatin binding activity and peroxisome proliferator activated receptor binding activity. Involved in positive regulation of lipid storage. Predicted to colocalize with nuclear chromatin. Orthologous to human ASXL2 (ASXL transcriptional regulator 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; valproic acid; (+)-catechin (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: additional sex combs like 2; additional sex combs like 2 (Drosophila); additional sex combs like 2, transcriptional regulator; additional sex combs like transcriptional regulator 2; LOC313922; LOW QUALITY PROTEIN: putative Polycomb group protein ASXL2; putative Polycomb group protein ASXL2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2626,425,017 - 26,514,899 (+)NCBI
Rnor_6.0 Ensembl627,887,797 - 27,915,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0627,835,346 - 27,919,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0637,644,433 - 37,732,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,400,855 - 26,482,465 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,470,864 - 26,484,531 (+)NCBI
Celera625,902,447 - 25,987,120 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
PR-DUB complex  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:19270745   PMID:20577743   PMID:21047783   PMID:21490954   PMID:23046516   PMID:24860998  


Genomics

Comparative Map Data
Asxl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2626,425,017 - 26,514,899 (+)NCBI
Rnor_6.0 Ensembl627,887,797 - 27,915,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0627,835,346 - 27,919,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0637,644,433 - 37,732,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,400,855 - 26,482,465 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,470,864 - 26,484,531 (+)NCBI
Celera625,902,447 - 25,987,120 (+)NCBICelera
Cytogenetic Map6q14NCBI
ASXL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl225,733,753 - 25,878,487 (-)EnsemblGRCh38hg38GRCh38
GRCh38225,733,753 - 25,878,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37225,956,622 - 26,101,356 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37225,962,253 - 26,101,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,815,757 - 25,954,816 (-)NCBINCBI36hg18NCBI36
Build 34225,873,909 - 26,013,007NCBI
Celera225,802,588 - 25,941,650 (-)NCBI
Cytogenetic Map2p23.3NCBI
HuRef225,699,339 - 25,838,712 (-)NCBIHuRef
CHM1_1225,891,914 - 26,030,899 (-)NCBICHM1_1
Asxl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,476,857 - 3,560,811 (+)NCBIGRCm39mm39
GRCm38123,426,857 - 3,510,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,426,857 - 3,506,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,426,884 - 3,506,849 (+)NCBIGRCm37mm9NCBIm37
MGSCv36123,426,901 - 3,502,468 (+)NCBImm8
Celera123,353,949 - 3,434,249 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
Asxl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,786,154 - 7,923,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,786,030 - 7,923,739 (-)NCBIChiLan1.0ChiLan1.0
ASXL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A25,824,278 - 25,973,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,832,527 - 25,973,659 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A25,730,155 - 25,880,089 (-)NCBIMhudiblu_PPA_v0panPan3
ASXL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1719,895,568 - 20,044,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11719,914,026 - 20,065,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Asxl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364936,463,771 - 6,602,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASXL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,044,836 - 113,180,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,044,788 - 113,184,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,991,762 - 120,173,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASXL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,770,068 - 81,919,200 (+)NCBI
Asxl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247387,958,610 - 8,100,223 (-)NCBI

Position Markers
BF404323  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0627,835,324 - 27,835,513NCBIRnor6.0
Rnor_5.0637,645,596 - 37,645,785UniSTSRnor5.0
RGSC_v3.4626,400,946 - 26,401,135UniSTSRGSC3.4
Celera625,902,425 - 25,902,614UniSTS
RH 3.4 Map6117.39UniSTS
Cytogenetic Map6q14UniSTS
BF399538  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0627,835,178 - 27,835,346NCBIRnor6.0
Rnor_5.0637,645,450 - 37,645,618UniSTSRnor5.0
RGSC_v3.4626,400,800 - 26,400,968UniSTSRGSC3.4
Celera625,902,279 - 25,902,447UniSTS
RH 3.4 Map6116.9UniSTS
Cytogenetic Map6q14UniSTS
AU048346  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0627,856,385 - 27,856,508NCBIRnor6.0
Rnor_5.0637,666,657 - 37,666,780UniSTSRnor5.0
RGSC_v3.4626,422,007 - 26,422,131UniSTSRGSC3.4
Celera625,923,486 - 25,923,610UniSTS
Cytogenetic Map6q14UniSTS
RH140747  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0627,835,655 - 27,835,800NCBIRnor6.0
Rnor_5.0637,645,927 - 37,646,072UniSTSRnor5.0
RGSC_v3.4626,401,277 - 26,401,422UniSTSRGSC3.4
Celera625,902,756 - 25,902,901UniSTS
RH 3.4 Map6117.5UniSTS
Cytogenetic Map6q14UniSTS
Asxl2DS-g-a-48f06_r1_177  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4626,458,168 - 26,458,168 (+)RGDRGSC3.4


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295834367603Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000015827, ENSRNOT00000061505
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 25 31 15 19 15 1 1 48 28 40 11 1
Low 2 17 26 26 26 7 9 26 7 1 7
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015827   ⟹   ENSRNOP00000015827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl627,887,797 - 27,915,563 (+)Ensembl
RefSeq Acc Id: XM_003754155   ⟹   XP_003754203
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,902,447 - 25,987,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003754156   ⟹   XP_003754204
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,902,447 - 25,987,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006225712   ⟹   XP_006225774
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,947,767 - 25,987,120 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006225713   ⟹   XP_006225775
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,924,714 - 25,987,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764542   ⟹   XP_008762764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0627,835,346 - 27,919,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764543   ⟹   XP_008762765
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0627,835,346 - 27,919,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776192   ⟹   XP_008774414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,919,554 - 25,987,120 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776193   ⟹   XP_008774415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,924,714 - 25,987,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776194   ⟹   XP_008774416
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera625,924,714 - 25,987,109 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113094   ⟹   XP_038969022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2626,425,017 - 26,514,899 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038969022 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03009 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003754203   ⟸   XM_003754155
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003754204   ⟸   XM_003754156
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006225775   ⟸   XM_006225713
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006225774   ⟸   XM_006225712
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008774414   ⟸   XM_008776192
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008774416   ⟸   XM_008776194
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008774415   ⟸   XM_008776193
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008762764   ⟸   XM_008764542
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008762765   ⟸   XM_008764543
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000015827   ⟸   ENSRNOT00000015827
RefSeq Acc Id: XP_038969022   ⟸   XM_039113094
Protein Domains
ASXH   PHD_3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304710 AgrOrtholog
Ensembl Genes ENSRNOG00000011908 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015827 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015827 UniProtKB/TrEMBL
InterPro ASX-like_PHD UniProtKB/TrEMBL
  ASX/ASX-like UniProtKB/TrEMBL
  ASXH UniProtKB/TrEMBL
  ASXL2 UniProtKB/TrEMBL
NCBI Gene 313922 ENTREZGENE
PANTHER PTHR13578 UniProtKB/TrEMBL
  PTHR13578:SF11 UniProtKB/TrEMBL
Pfam ASXH UniProtKB/TrEMBL
  PHD_3 UniProtKB/TrEMBL
PhenoGen Asxl2 PhenoGen
UniProt D3Z8N9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Asxl2  ASXL transcriptional regulator 2  Asxl2  additional sex combs like 2, transcriptional regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Asxl2  additional sex combs like 2, transcriptional regulator  Asxl2  additional sex combs like transcriptional regulator 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-06-25 Asxl2  additional sex combs like transcriptional regulator 2  Asxl2  additional sex combs like 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Asxl2  additional sex combs like 2 (Drosophila)   Asxl2_predicted  additional sex combs like 2 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Asxl2_predicted  additional sex combs like 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED