Slc49a3 (solute carrier family 49 member 3)

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Gene: Slc49a3 (solute carrier family 49 member 3) Rattus norvegicus

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Symbol:

Slc49a3

Name:

solute carrier family 49 member 3

RGD ID:

1304688

Description:

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC49A3 (solute carrier family 49 member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC305625; major facilitator superfamily domain containing 7; major facilitator superfamily domain-containing protein 7; Mfsd7; RGD1304688; similar to RIKEN cDNA 4732482E20; solute carrier family 49 member A3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC49A3 (solute carrier family 49 member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc49a3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc49a3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC49A3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC49A3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc49a3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC49A3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC49A3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc49a3 (solute carrier family 49 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Slc49a3 (solute carrier family 49 member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC49A3 (solute carrier family 49 member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	B0416.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	slc49a3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C05G5.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C42C1.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc49a3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,448,274 - 1,459,126 (+)	NCBI		GRCr8
mRatBN7.2	14	1,305,091 - 1,319,723 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,305,680 - 1,314,132 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,187,477 - 1,195,868 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,489,234 - 2,497,625 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,185,909 - 1,194,300 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,309,759 - 2,322,269 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,311,122 - 2,319,574 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,308,778 - 2,323,663 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,853,158 - 1,861,610 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	1,848,596 - 1,860,673 (+)	NCBI
Celera	14	1,327,581 - 1,336,029 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cherubism (ISO)

Mental Retardation, Autosomal Recessive 53 (ISO)

retinitis pigmentosa 40 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

cisplatin (ISO)

Cuprizon (EXP)

DDE (ISO)

ethanol (ISO)

fulvestrant (ISO)

gentamycin (EXP)

inulin (ISO)

manganese(II) chloride (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

Triptolide (EXP)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

transmembrane transport (IEA)

Cellular Component

membrane (IBA)

Molecular Function

protein binding (ISO)

transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Slc49a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,448,274 - 1,459,126 (+)	NCBI		GRCr8
mRatBN7.2	14	1,305,091 - 1,319,723 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,305,680 - 1,314,132 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,187,477 - 1,195,868 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,489,234 - 2,497,625 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,185,909 - 1,194,300 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,309,759 - 2,322,269 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,311,122 - 2,319,574 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,308,778 - 2,323,663 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,853,158 - 1,861,610 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	1,848,596 - 1,860,673 (+)	NCBI
Celera	14	1,327,581 - 1,336,029 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

SLC49A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	676,826 - 691,624 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	681,829 - 689,271 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	675,618 - 682,940 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	665,618 - 672,973 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	616,683 - 623,713 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	650,451 - 655,312 (-)	NCBI		HuRef
CHM1_1	4	675,408 - 682,763 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	676,500 - 691,967 (-)	NCBI		T2T-CHM13v2.0

Slc49a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,588,920 - 108,598,631 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,588,920 - 108,596,966 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	108,441,052 - 108,450,765 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,441,054 - 108,449,100 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	108,870,073 - 108,877,910 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,681,356 - 108,689,193 (-)	NCBI		MGSCv36	mm8
Celera	5	105,561,240 - 105,569,077 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	53.11	NCBI

Slc49a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	289,874 - 295,127 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	289,301 - 295,443 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC49A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	990,660 - 998,391 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	948,723 - 956,381 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	725,725 - 733,127 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	715,736 - 723,399 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	715,736 - 723,399 (-)	Ensembl	panpan1.1		panPan2

SLC49A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	91,732,589 - 91,738,161 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	91,731,437 - 91,737,753 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	94,196,598 - 94,203,629 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	92,730,706 - 92,737,740 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	92,730,043 - 92,743,145 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	91,901,848 - 91,909,457 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	91,956,586 - 91,964,802 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	92,339,460 - 92,346,496 (+)	NCBI		UU_Cfam_GSD_1.0

Slc49a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	68,681,966 - 68,715,851 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	22,403,239 - 22,409,878 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	22,403,186 - 22,410,563 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC49A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	120,102 - 128,425 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	120,088 - 128,420 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	158,066 - 163,220 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC49A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	48,097,722 - 48,106,367 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	48,098,727 - 48,106,238 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	4,484,579 - 4,492,558 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc49a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	26,356,154 - 26,361,611 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	26,356,236 - 26,361,799 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc49a3
48 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	418
Count of miRNA genes:	235
Interacting mature miRNAs:	272
Transcripts:	ENSRNOT00000037459
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat

Markers in Region

BF390294

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	1,313,967 - 1,314,124 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	2,319,410 - 2,319,566	NCBI	Rnor6.0
Rnor_5.0	14	2,317,764 - 2,317,920	UniSTS	Rnor5.0
RGSC_v3.4	14	1,861,446 - 1,861,602	UniSTS	RGSC3.4
Celera	14	1,335,865 - 1,336,021	UniSTS
RH 3.4 Map	14	14.5	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	59	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037459 ⟹ ENSRNOP00000037657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,305,680 - 1,314,132 (+)	Ensembl
Rnor_6.0 Ensembl	14	2,311,122 - 2,319,574 (+)	Ensembl

RefSeq Acc Id:

NM_001107246 ⟹ NP_001100716

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,450,674 - 1,459,126 (+)	NCBI
mRatBN7.2	14	1,305,680 - 1,314,132 (+)	NCBI
Rnor_6.0	14	2,311,122 - 2,319,574 (+)	NCBI
Rnor_5.0	14	2,308,778 - 2,323,663 (+)	NCBI
RGSC_v3.4	14	1,853,158 - 1,861,610 (+)	RGD
Celera	14	1,327,581 - 1,336,029 (+)	RGD

Sequence:

show sequence

CGCGGACGTGTTCATGGTACAGGCCATACACACTTGTATCCAAATTACCTCTTAAAAGGAAATT
TTTGCCCTCCGGTTTTCAACTCGGCTTCTGTCTGTGGGTAATCCTGGTTTCCTTTCACCAAACT
TGTCCTTCGGGGCGGAGACTAACCAGATCATTCCGCCCCGCCCTGCTCCTGGGACAGCCTACCC
ACCGCTGCAGCGCTTTGCAGTGTAATGCAAGTGGGCGGCCCGCAGACACTGGGATGGCCCGGAC
TATGGACCGACTGGAAGCCTGCAACAGCCCGGGAACATCTGGGACCCCCGGAGACGCGTTGCCT
GGTCCCCGTGTATATGCGCGCCGCTGGGTCTTTCTGCTGGTGGTTAGCCTCCTGAGCTGCTCCA
ACGCGATGCTCTGGCTCACCTTCGCGCCCGTAGCAGACACCATAGCGCAGCACTTCTCCCTGTC
CATGGACCAGATCAACTGGCTGTCACTAATATACCTTGTGTTATCCATCCCATTTGGCATGGCA
GCCATATGGGTTCTGGACTCTGTTGGCCTCCGTGGAGCGACTATCCTGGGTGCATGGCTGAATT
TTTCTGGGAGTTTGCTACGTGCTGTGCCGTGCTTGGCTGTCAGGATCCCCAGTCCCTTTGCCTT
CTTCATGAGTGGCCAGAGCCTCTGTGCTCTGGCCCAGACCCTGGTCATCTCTTCTCCAGCCAAG
CTGGCTGCCTTGTGGTTTCCAGAGCACCAACGAGCCACAGCTAACATGATCGGCACCATGTCAA
ATCCTCTGGGCATCCTAATAGCAAATGTGCTGTCTCCTGCCCTCGTCAAGAAAGCAGAAGACAT
CCCTATGATGCTTGGCATCTACATCGTTCCTGCTGCCCTTGCCTGTCTGTTGGCCACTGTCTGC
CTCTGGGAGAGTGTGCCTCCTACCCCACCGTCCGCAGGGGCTGCCAGCTCTACTTCAGAGAGTT
TCCTCCACGGGCTCAAACTGCTCATGAAGAATAAGGCCTATGTCATCCTGGCCGTATGCTTCGG
TGGTGGCATCGGTGTCTTCTCCAGCTTCTCAGCCCTCCTGGAACAGATCTTTTGTGCCAACGGC
TACTCTAATGAGTTCTCAGGCCTCTGTGGGGCTCTCTTCATCGTGTTTGGAATTTTGGGGGCAC
TGCTTCTAGGCCTGTATGTGGACCGGACCAAGCACTTCACCGAAGCCACCAAGATAGGCCTCTG
TTTGACTTCCCTGACCTTCGTGGCCTTCGCTCTGGTATCCCAGCTGCAGGGACAGACCTTTGCA
CTGGCTGCCATCTGCTCTCTCCTTGGGCTCTTTGGCTTCTCGGTGGCACCTGTGGTCATGGAGC
TGGCAGTTGAGTGTTCGTTTCCTGTGGGTGAGGGTGCCTCTGCTGGCTTGATCTTTGTCCTGGG
GCAGGCCGAGGGCGTGCTCATCATGCTGCTATTGACGGCAGTGACTGTGCGGCGAACAGGCCCA
TCCTTCTCTACCTGCCGGCAGGGTGAGGACCCTCTGGACTGGACAGTGTCCCTGCTGCTGCTGG
CTGGCCTATGTACCCTTTTCACCTGTGTCTTGGTGATCTTCTTCAACACACCATACCGGCGCCT
GGAGGCTGAGTCTGGAGGATCCTCTTCACCCATGATGTGTGCCGGGGATCCAAGAAATGAAAGC
CCCACCCAAGTGGCACCACTTGAGACTCCTGGCTTGACACCTCCAGACGACGCCTTGCAGGAAG
CTCCTGGGCCTGCTTCTGTCTCCAAAGGACACTCAGAATGGACAGAGACCATAACCAGAAATGT
CTAGTAAAGCATAGGGTTGCTAGGGTCTCTTTGTGCCAGCAATCCCTCTGACAGGGACACACAG
TCCTTAACAGACCCAGGGTATGATTAGGATGGCCTTTTGGTCCTCAGGAAGACTGTGGTGGAAT
TGAAAATAACTGCTGTTGAATGGATACTAGTCAGTTAGGGTGGACCCTGGCCAAGCCATATTTA
TGGTGGCTACTGCAAGAGGGCCTGTGCAGGGCCAAAGGGAGGGAGTTAGAGACTCCTGGCATAA
GACCTGGGGCGTTCTGAAGGCTATGGCATGACCGGTCTGAGGCAGACAGGTGTAGGAAGAACTT
GTCTCCACTGTCTCACCAGGCACTGAGCCCGATTCTAAAACAGCACAGAGGGTGGTGAGCTGGT
CTGAGCAGAGTAGGGAACACATTCCCTGCAATGAACACCCCTAGGGATGTTTATGTGTCCAACT
TTATTGAGTGATTGAGCAGCATATACTTCCTCCTCCACATGGGCAAGCATAGAGCTCAACACTT
TGTGGTCTAGGTTGCCAGCCACAGCAATGAAGGCAAGCACCAGCATGTGAGTTAGGTGGGGTAT
CGAGGGGGAAGTCATGTTGGTGGTGGTAGGAGGAGGAGAGACAAGGTTCCTGGGCTCCAGCAGC
CCTGACACTGTAAATTACAGGCACCAAACTCCTTTCAGTGGGTTCCAGACTCTGGTTTGACCTG
GTCAGGGGTGAAAAAGGTCAGTGGGCCAAGGGCCAGGCCAGGGAAGGGGCTGGGGATGTATGCA
AAGTAAGGTCAGAAGAGGGATTGGAGGAAGTGGGGCGGAGAGGGGTGGGAGAAGGGAAACTGTA
AGAGAGGGAAATGGAGGGAAGAAAGGGGTGGGATACTGTGAGTAATGTGTTGGTGGGAGTGATG
GGAGTGGTAAATAAATGGAATAGACATGCTGGAAACCTAGACCTT

hide sequence

RefSeq Acc Id:

XR_005492981

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,448,274 - 1,458,049 (+)	NCBI
mRatBN7.2	14	1,305,091 - 1,313,055 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100716	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84010	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037657.4

RefSeq Acc Id:

NP_001100716 ⟸ NM_001107246

- UniProtKB:

D3ZU10 (UniProtKB/TrEMBL), A6KPF4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARTMDRLEACNSPGTSGTPGDALPGPRVYARRWVFLLVVSLLSCSNAMLWLTFAPVADTIAQH
FSLSMDQINWLSLIYLVLSIPFGMAAIWVLDSVGLRGATILGAWLNFSGSLLRAVPCLAVRIPS
PFAFFMSGQSLCALAQTLVISSPAKLAALWFPEHQRATANMIGTMSNPLGILIANVLSPALVKK
AEDIPMMLGIYIVPAALACLLATVCLWESVPPTPPSAGAASSTSESFLHGLKLLMKNKAYVILA
VCFGGGIGVFSSFSALLEQIFCANGYSNEFSGLCGALFIVFGILGALLLGLYVDRTKHFTEATK
IGLCLTSLTFVAFALVSQLQGQTFALAAICSLLGLFGFSVAPVVMELAVECSFPVGEGASAGLI
FVLGQAEGVLIMLLLTAVTVRRTGPSFSTCRQGEDPLDWTVSLLLLAGLCTLFTCVLVIFFNTP
YRRLEAESGGSSSPMMCAGDPRNESPTQVAPLETPGLTPPDDALQEAPGPASVSKGHSEWTETI
TRNV

hide sequence

Ensembl Acc Id:

ENSRNOP00000037657 ⟸ ENSRNOT00000037459

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZU10-F1-model_v2	AlphaFold	D3ZU10	1-516	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304688	AgrOrtholog
BioCyc Gene	G2FUF-16676	BioCyc
Ensembl Genes	ENSRNOG00000023937	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037459.5	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	Major_facilitator_SF	UniProtKB/TrEMBL
	MFS_1	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
	SLC49-like	UniProtKB/TrEMBL
KEGG Report	rno:305625	UniProtKB/TrEMBL
NCBI Gene	305625	ENTREZGENE
PANTHER	MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED	UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 49 MEMBER A3	UniProtKB/TrEMBL
Pfam	MFS_1	UniProtKB/TrEMBL
PhenoGen	Slc49a3	PhenoGen
PROSITE	MFS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000023937	RatGTEx
Superfamily-SCOP	MFS_gen_substrate_transporter	UniProtKB/TrEMBL
UniProt	A6KPF4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZU10	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	Slc49a3	solute carrier family 49 member 3	Mfsd7	major facilitator superfamily domain containing 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Mfsd7	major facilitator superfamily domain containing 7	RGD1304688_predicted	similar to RIKEN cDNA 4732482E20 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1304688_predicted	similar to RIKEN cDNA 4732482E20 (predicted)	LOC305625_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC305625_predicted	similar to RIKEN cDNA 4732482E20 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar