Prss45 (serine protease 45) - Rat Genome Database

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Gene: Prss45 (serine protease 45) Rattus norvegicus
Analyze
Symbol: Prss45
Name: serine protease 45
RGD ID: 1303021
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human PRSS45P (serine protease 45, pseudogene); INTERACTS WITH bisphenol A; glyphosate; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive serine protease 45; inactive testis serine protease 5; protease, serine, 45; Tessp5; testis serine protease 5; testis-specific serine protease-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,698,713 - 119,704,492 (+)NCBIGRCr8
mRatBN7.28110,820,301 - 110,826,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,820,273 - 110,826,120 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,434,369 - 116,439,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,633,581 - 114,639,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,476,411 - 112,481,935 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,112,726 - 119,118,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,112,678 - 119,118,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,451,036 - 118,456,674 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,224,794 - 115,230,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,244,248 - 115,249,787 (+)NCBI
Celera8110,102,906 - 110,108,428 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prss45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,698,713 - 119,704,492 (+)NCBIGRCr8
mRatBN7.28110,820,301 - 110,826,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,820,273 - 110,826,120 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,434,369 - 116,439,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,633,581 - 114,639,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,476,411 - 112,481,935 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,112,726 - 119,118,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,112,678 - 119,118,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,451,036 - 118,456,674 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,224,794 - 115,230,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,244,248 - 115,249,787 (+)NCBI
Celera8110,102,906 - 110,108,428 (+)NCBICelera
Cytogenetic Map8q32NCBI
PRSS45P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,742,091 - 46,744,755 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,742,350 - 46,750,891 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,783,581 - 46,786,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,758,585 - 46,761,249 (-)NCBINCBI36Build 36hg18NCBI36
Celera346,722,083 - 46,724,746 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,826,375 - 46,829,039 (-)NCBIHuRef
CHM1_1346,733,717 - 46,736,381 (-)NCBICHM1_1
T2T-CHM13v2.0346,758,176 - 46,760,840 (-)NCBIT2T-CHM13v2.0
Prss45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,663,656 - 110,670,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,663,656 - 110,670,381 (+)EnsemblGRCm39 Ensembl
GRCm389110,834,588 - 110,841,310 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,834,588 - 110,841,313 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,737,092 - 110,743,814 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,679,404 - 110,686,126 (+)NCBIMGSCv36mm8
Celera9110,565,323 - 110,572,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Prss45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,400,499 - 25,408,892 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,400,359 - 25,408,044 (+)NCBIChiLan1.0ChiLan1.0
PRSS45P
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,697,862 - 46,706,853 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,702,632 - 46,711,623 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,641,972 - 46,650,897 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,743,464 - 47,752,177 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,743,723 - 47,746,127 (-)Ensemblpanpan1.1panPan2
LOC476645
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,007,085 - 42,016,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,923,268 - 41,932,329 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,489,674 - 42,498,721 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12041,731,104 - 41,740,004 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,131,970 - 42,140,802 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,413,044 - 42,421,869 (+)NCBIUU_Cfam_GSD_1.0
LOC101959260
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,018,817 - 201,026,847 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936596568,655 - 586,331 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100515578
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,676,977 - 29,685,937 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,676,713 - 29,685,965 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,926,026 - 32,935,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227548
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,164,870 - 8,177,432 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,162,821 - 8,167,629 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041158,973,804 - 158,985,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prss45
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:52
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000043249
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat

Markers in Region
BF390882  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,825,870 - 110,826,042 (+)MAPPERmRatBN7.2
Rnor_6.08119,118,273 - 119,118,444NCBIRnor6.0
Rnor_5.08118,456,683 - 118,456,854UniSTSRnor5.0
RGSC_v3.48115,230,341 - 115,230,512UniSTSRGSC3.4
Celera8110,108,437 - 110,108,608UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 10
Low 1 15
Below cutoff 1 1 3 2 2 2 2 4 8 6 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000043249   ⟹   ENSRNOP00000040152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,820,273 - 110,826,120 (+)Ensembl
Rnor_6.0 Ensembl8119,112,678 - 119,118,533 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111118   ⟹   ENSRNOP00000096449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,820,324 - 110,825,862 (+)Ensembl
RefSeq Acc Id: NM_001008864   ⟹   NP_001008864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,698,713 - 119,704,492 (+)NCBI
mRatBN7.28110,820,301 - 110,826,080 (+)NCBI
Rnor_6.08119,112,726 - 119,118,264 (+)NCBI
Rnor_5.08118,451,036 - 118,456,674 (+)NCBI
RGSC_v3.48115,224,794 - 115,230,332 (+)RGD
Celera8110,102,906 - 110,108,428 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008864 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE48386 (Get FASTA)   NCBI Sequence Viewer  
  EDL77053 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040152
  ENSRNOP00000040152.1
  ENSRNOP00000096449.1
GenBank Protein Q6IE62 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008864   ⟸   NM_001008864
- Peptide Label: precursor
- UniProtKB: Q6IE62 (UniProtKB/Swiss-Prot),   A6I3H4 (UniProtKB/TrEMBL),   A0A8I6AV39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040152   ⟸   ENSRNOT00000043249
RefSeq Acc Id: ENSRNOP00000096449   ⟸   ENSRNOT00000111118
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE62-F1-model_v2 AlphaFold Q6IE62 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696337
Promoter ID:EPDNEW_R6862
Type:initiation region
Name:Prss45_1
Description:protease, serine, 45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,112,703 - 119,112,763EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303021 AgrOrtholog
BioCyc Gene G2FUF-29051 BioCyc
Ensembl Genes ENSRNOG00000029649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043249 ENTREZGENE
  ENSRNOT00000043249.3 UniProtKB/Swiss-Prot
  ENSRNOT00000111118.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:408244 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 408244 ENTREZGENE
PANTHER PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  SERINE PROTEASE 45-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
  TRYPTASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss45 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029649 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AV39 ENTREZGENE, UniProtKB/TrEMBL
  A6I3H4 ENTREZGENE, UniProtKB/TrEMBL
  PRS45_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss45  serine protease 45  Prss45  protease, serine, 45  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Prss45  protease, serine, 45  Tessp5  testis serine protease 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Tessp5  testis serine protease 5  Tessp5  testis-specific serine protease-5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Tessp5  testis-specific serine protease-5      Symbol and Name status set to provisional 70820 PROVISIONAL