Cdkn1b<sup>we</sup> (cyclin-dependent kinase inhibitor 1B; white eye mutation) - Rat Genome Database

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Gene: Cdkn1bwe (cyclin-dependent kinase inhibitor 1B; white eye mutation) Rattus norvegicus
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Symbol: Cdkn1bwe
Name: cyclin-dependent kinase inhibitor 1B; white eye mutation
RGD ID: 12910941
Description: A tandem duplication of 8 nt in exon 2 of the rat Cdkn1b was identified in the Sprague-Dawley white eye mutant strain. The 8-nt insertion results in a frameshift after codon 177 (p. G177fs), predicting a different C-terminal domain containing 42 p27-unrelated amino acid residues.
ASSOCIATED WITH increased pheochromocytoma incidence; thyroid gland hyperplasia; ASSOCIATED WITH cataract; multiple endocrine neoplasia; paraganglioma
Type: allele  of Cdkn1b  
Previously known as: Cdkn1bwe; p27-G177fs
Is Marker For: Strains:   SD-Cdkn1bwe  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Fritz A, etal., Cancer Res 2002 Jun 1;62(11):3048-51.
2. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Pellegata NS, etal., Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15558-63. Epub 2006 Oct 9.

Genomics


Related Rat Strains
The following Strains have been annotated to Cdkn1bwe


Expression


Sequence

Nucleotide Sequences


Additional Information