Mmp12<sup>em2Soar</sup> (matrix metallopeptidase 12; TALEN induced mutant 2,Soar)

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Gene: Mmp12^em2Soar (matrix metallopeptidase 12; TALEN induced mutant 2,Soar) Rattus norvegicus

Symbol:	Mmp12^em2Soar
Name:	matrix metallopeptidase 12; TALEN induced mutant 2,Soar
RGD ID:	12910506
Description:	The TALEN genome editing system caused a 607-bp deletion in the exon 2 of rat Mmp12 ASSOCIATED WITH decreased fetal weight; decreased litter size
Type:	allele of Mmp12
Previously known as:	Mmp12^[em2Soar]; Mmp12em2Soar
Is Marker For:	Strains: SD-Mmp12^em2Soar
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated

#	Reference Title	Reference Citation
1.	HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.	Chakraborty D, etal., Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2.

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Mmp12em2Soar-var1	chr8	4582897	4583503	TGCAATGCTTGTGTTTTGTCTAGTGGTACTTGTCAAGATTTTTTGACTATCAAGGGGACAGAATTCCAATGACAAAAACAAAAACCAATAGAAACCTCCTAGAAGAAAAACTCCAGGAAATGCAGCAGTTCTTTGGGCTAGAAGTAACTGGGCAACTGGACACCTCAACTCTGAAAATAATGCACACGTCTCGATGTGGAGTGCCTGATGTACAGCATCTTAGAGCAGTGCCCCAGAGGTCAAGATGGATGAAGCGGTATCTCACTTACAGGTAATGTCATTGGAGAACTCTTCTACTTGCCTATGAGTGTAGCCTCTAGAACCCTAGAACATTTAGCTACAACGAAATTCTAAATCCAAGAGTAGCCTCTGCAAATTGTTAATACAAATGTGTTCATTTTCTCCAGACTGGGTTGATGGCTCAGTGGAAAAAGCACTTGTCATACACTATAAGGGCCAGAGTTCAGACCACAAGAAGCCAGGCATGGCGGCTGCCTATAATCCCAGCACATGGGAGGAAGAGATGGGGATGCCTAGGGCAAGTTGGCTAGCCAGATTAGTAGAATTAGGGGTCTTTGGCTTTGGTTGAGAGAACTTTCCTCAATAA	-	deletion	mRatBN7.2
Mmp12em2Soar-var1	chr8	5607704	5608310	TGCAATGCTTGTGTTTTGTCTAGTGGTACTTGTCAAGATTTTTTGACTATCAAGGGGACAGAATTCCAATGACAAAAACAAAAACCAATAGAAACCTCCTAGAAGAAAAACTCCAGGAAATGCAGCAGTTCTTTGGGCTAGAAGTAACTGGGCAACTGGACACCTCAACTCTGAAAATAATGCACACGTCTCGATGTGGAGTGCCTGATGTACAGCATCTTAGAGCAGTGCCCCAGAGGTCAAGATGGATGAAGCGGTATCTCACTTACAGGTAATGTCATTGGAGAACTCTTCTACTTGCCTATGAGTGTAGCCTCTAGAACCCTAGAACATTTAGCTACAACGAAATTCTAAATCCAAGAGTAGCCTCTGCAAATTGTTAATACAAATGTGTTCATTTTCTCCAGACTGGGTTGATGGCTCAGTGGAAAAAGCACTTGTCATACACTATAAGGGCCAGAGTTCAGACCACAAGAAGCCAGGCATGGCGGCTGCCTATAATCCCAGCACATGGGAGGAAGAGATGGGGATGCCTAGGGCAAGTTGGCTAGCCAGATTAGTAGAATTAGGGGTCTTTGGCTTTGGTTGAGAGAACTTTCCTCAATAA	-	deletion	Rnor_6.0

Related Rat Strains

The following Strains have been annotated to Mmp12^em2Soar

SD-Mmp12^em2Soar

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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