Lep<sup>em1Sage</sup> (leptin; zinc finger nuclease induced mutant1, Sage) - Rat Genome Database

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Gene: Lepem1Sage (leptin; zinc finger nuclease induced mutant1, Sage) Rattus norvegicus
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Symbol: Lepem1Sage
Name: leptin; zinc finger nuclease induced mutant1, Sage
RGD ID: 12904927
Description: This allele possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene.
ASSOCIATED WITH abnormal interferon level; decreased T cell number; increased body weight; ASSOCIATED WITH glucose intolerance; Hypercholesterolemia; hyperinsulinism
Type: allele  of Lep  
Previously known as: Lep tm1sage; Lep^[em1Sage]; Lepem1Sage
Is Marker For: Strains:   SD-Lepem1Sage-/-   SD-Lepem1Sage+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Lepem1Sage-var1 chr4 57670525 57670675 ATCCACAAAGTCCAGGATGACACCAAAACCCTCATCAAGACCATTGTCACCAGGATCAATGACATTTCACACACGGTAGGGAGTCTCTTGTGGGGAAGCAAAGGAGAAGTAGGGCTAGAACCAGAGTCTGAGAATCACAGTGAGCGCCTTC - deletion mRatBN7.2
Lepem1Sage-var1 chr4 56347081 56347231 ATCCACAAAGTCCAGGATGACACCAAAACCCTCATCAAGACCATTGTCACCAGGATCAATGACATTTCACACACGGTAGGGAGTCTCTTGTGGGGAAGCAAAGGAGAAGTAGGGCTAGAACCAGAGTCTGAGAATCACAGTGAGCGCCTTC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Lepem1Sage
SD-Lepem1Sage+/-     SD-Lepem1Sage-/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information