Zrs1 (zone of polarising activity regulatory sequence 1) - Rat Genome Database

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Gene: Zrs1 (zone of polarising activity regulatory sequence 1) Mus musculus
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Symbol: Zrs1
Name: zone of polarising activity regulatory sequence 1
RGD ID: 12904780
MGI Page MGI
Description: This locus represents a highly conserved functional element that is located in an intron of the limb development membrane protein 1 gene. In the developing limb bud, this element functions as a long-range enhancer of the sonic hedgehog (Shh) gene, which is located approximately 1 Mb downstream. Multiple transcription factor binding sites have been identified, and long-range looping interactions have been shown between this element and the Shh gene. Mutations in this element disrupt limb patterning in mice. In the orthologous human element, mutations can result in a range of congenital limb malformations, including preaxial polydactyly, triphalangeal thumbs, Werner mesomelic syndrome (WMS) and polysyndactyly. [provided by RefSeq, Feb 2019]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: Mfcs1; Zrs; Zrs/Lmbr1
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39529,519,495 - 29,520,860 (+)NCBIGRCm39GRCm39mm39
GRCm38529,314,497 - 29,315,862 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:12837695   PMID:14727139   PMID:15677727   PMID:17049204   PMID:17130149   PMID:18156157   PMID:18178630   PMID:18463159   PMID:19097946   PMID:19154714   PMID:19369396   PMID:20386744  
PMID:21465618   PMID:22286052   PMID:22340503   PMID:23650631   PMID:23686920   PMID:24715461   PMID:24777739   PMID:24965254   PMID:27402708   PMID:27768887   PMID:27773569   PMID:28710291  
PMID:28793263   PMID:28949289   PMID:29543231   PMID:29556077   PMID:30213538  


Genomics

Comparative Map Data
Zrs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39529,519,495 - 29,520,860 (+)NCBIGRCm39GRCm39mm39
GRCm38529,314,497 - 29,315,862 (+)NCBIGRCm38GRCm38mm10GRCm38
ZRS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387156,790,708 - 156,793,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377156,583,402 - 156,585,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7qNCBI
T2T-CHM13v2.07157,978,491 - 157,980,862 (+)NCBIT2T-CHM13v2.0

Variants

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Variants in Zrs1
53 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse


Expression


Sequence



Additional Information

Database Acc Id Source(s)
MGD MGI:3028525 ENTREZGENE
NCBI Gene Zrs1 ENTREZGENE
PhenoGen Zrs1 PhenoGen