Nr1i2<sup>em1Sage</sup> (nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage)

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Gene: Nr1i2^em1Sage (nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage) Rattus norvegicus

Analyze

Symbol:

Nr1i2^em1Sage

Name:

nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage

RGD ID:

12902626

Description:

This ZFN induced allele contains a 20-bp deletion within exon 2 of the Nr1i2 gene.
ASSOCIATED WITH abnormal enzyme/coenzyme level; increased body weight; increased thyroid gland weight

Type:

allele of Nr1i2

Previously known as:

Nr1i2 ^em1Sage; Nr1i2 em1Sage; nuclear receptor subfamily 1, group I, member 2; endonuclease induced mutant1, SAGE

Is Marker For:

Strains: SD-Nr1i2^em1Sage SD-Nr1i2^em1Sage Nr1i3^em1Sage SD-Nr1i2^em1Sage Nr1i3^em1Sage Ahr^em1Sage

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	11	65,043,639 - 65,043,757	RGD	Rnor6.0	Rnor_6.0	rn6	Rnor6.0

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal enzyme/coenzyme level (IMP)

increased body weight (IMP)

increased thyroid gland weight (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats.	Forbes KP, etal., Drug Metab Dispos. 2017 Oct;45(10):1068-1076. doi: 10.1124/dmd.117.075788. Epub 2017 Jul 17.
2.	Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.	Haines C, etal., Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13.
3.	Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase.	Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.

Genomics

Related Rat Strains

The following Strains have been annotated to Nr1i2^em1Sage

SD-Nr1i2^em1Sage

SD-Nr1i2^em1Sage Nr1i3^em1Sage

SD-Nr1i2^em1Sage Nr1i3^em1Sage Ahr^em1Sage

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-14	Nr1i2^em1Sage	nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage	Nr1i2 ^em1Sage	nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage	Symbol changed	629549	APPROVED
2017-06-20	Nr1i2 ^em1Sage	nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage	Nr1i2 ^em1Sage	nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, SAGE	Name changed	629549	APPROVED
2017-06-20	Nr1i2 ^em1Sage	nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, SAGE	Nr1i2 ^em1Sage	nuclear receptor subfamily 1, group I, member 2; endonuclease induced mutant1, SAGE	Name changed	629549	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype