Nr1i2<sup>em1Sage</sup> (nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage) - Rat Genome Database

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Gene: Nr1i2em1Sage (nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage) Rattus norvegicus
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Symbol: Nr1i2em1Sage
Name: nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage
RGD ID: 12902626
Description: This ZFN induced allele contains a 20-bp deletion within exon 2 of the Nr1i2 gene.
ASSOCIATED WITH abnormal enzyme/coenzyme level; increased body weight; increased thyroid gland weight
Type: allele  of Nr1i2  
Previously known as: Nr1i2 em1Sage; Nr1i2 em1Sage; nuclear receptor subfamily 1, group I, member 2; endonuclease induced mutant1, SAGE
Is Marker For: Strains:   SD-Nr1i2em1Sage   SD-Nr1i2em1Sage Nr1i3em1Sage   SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,043,639 - 65,043,757RGDRnor6.0Rnor_6.0rn6Rnor6.0


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats. Forbes KP, etal., Drug Metab Dispos. 2017 Oct;45(10):1068-1076. doi: 10.1124/dmd.117.075788. Epub 2017 Jul 17.
2. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Haines C, etal., Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13.
3. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.

Genomics


Related Rat Strains
The following Strains have been annotated to Nr1i2em1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-14 Nr1i2em1Sage  nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage  Nr1i2 em1Sage  nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage  Symbol changed 629549 APPROVED
2017-06-20 Nr1i2 em1Sage  nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage  Nr1i2 em1Sage  nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, SAGE  Name changed 629549 APPROVED
2017-06-20 Nr1i2 em1Sage  nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, SAGE  Nr1i2 em1Sage  nuclear receptor subfamily 1, group I, member 2; endonuclease induced mutant1, SAGE  Name changed 629549 APPROVED