Lep<sup>m1Kyo</sup> (leptin; ENU induced mutant1, Kyo) - Rat Genome Database

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Gene: Lepm1Kyo (leptin; ENU induced mutant1, Kyo) Rattus norvegicus
Symbol: Lepm1Kyo
Name: leptin; ENU induced mutant1, Kyo
RGD ID: 12792963
Description: A nonsense mutation (Q92X) was induced by N-ethyl-N-nitrosourea (ENU) in F344/NSlc rats.
ASSOCIATED WITH increased circulating cholesterol level; increased circulating triglyceride level; increased liver triglyceride level; ASSOCIATED WITH Insulin Resistance; obesity
Type: allele  of Lep  
Previously known as: Lepm1Kyo
Is Marker For: Strains:   F344-Lepm1Kyo   W.F344-Lepm1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.


Related Rat Strains
The following Strains have been annotated to Lepm1Kyo



Nucleotide Sequences

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Lepm1Kyo-var1 chr4 57672294 57672294 C T point_mutation
Lepm1Kyo-var1 chr4 56348850 56348850 C T point_mutation

Additional Information