Lep<sup>m1Kyo</sup> (leptin; ENU induced mutant1, Kyo) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lepm1Kyo (leptin; ENU induced mutant1, Kyo) Rattus norvegicus
Symbol: Lepm1Kyo
Name: leptin; ENU induced mutant1, Kyo
RGD ID: 12792963
Description: A nonsense mutation (Q92X) was induced by N-ethyl-N-nitrosourea (ENU) in F344/NSlc rats.
ASSOCIATED WITH increased circulating cholesterol level; increased circulating triglyceride level; increased liver triglyceride level; ASSOCIATED WITH Insulin Resistance; obesity
Type: allele  of Lep  
Previously known as: Lep^[m1Kyo]; Lepm1Kyo
Is Marker For: Strains:   F344-Lepm1Kyo   W.F344-Lepm1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Lepm1Kyo-var1 chr4 57672294 57672294 C T point_mutation mRatBN7.2
Lepm1Kyo-var1 chr4 56348850 56348850 C T point_mutation Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Lepm1Kyo



Nucleotide Sequences

Additional Information