Srd5a3 (steroid 5 alpha-reductase 3)

Gene: Srd5a3 (steroid 5 alpha-reductase 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Srd5a3

Name:

steroid 5 alpha-reductase 3

RGD ID:

12734007

Description:

ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (inferred); 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity (inferred); oxidoreductase activity (inferred); INVOLVED IN dolichol biosynthetic process (inferred); dolichol metabolic process (inferred); dolichol-linked oligosaccharide biosynthetic process (inferred); ASSOCIATED WITH autistic disorder (ortholog); cone dystrophy (ortholog); congenital disorder of glycosylation (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

polyprenol reductase; steroid 5 alpha-reductase 3, transcript variant X1; steroid 5 alpha-reductase 3, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	28,553,298 - 28,570,808 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	17,727,310 - 17,745,225 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	17,727,418 - 17,744,780 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

cone dystrophy (ISO)

congenital disorder of glycosylation (ISO)

congenital disorder of glycosylation Iq (ISO)

congenital disorder of glycosylation type IIk (ISO)

Creutzfeldt-Jakob disease (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

hemangioma (ISO)

intellectual disability (ISO)

Kahrizi syndrome (ISO)

Muscle Hypotonia (ISO)

Nervous System Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dolichol biosynthetic process (IEA)

dolichol metabolic process (IEA)

dolichol-linked oligosaccharide biosynthetic process (IEA)

lipid metabolic process (IEA)

polyprenol catabolic process (IEA)

protein glycosylation (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

3-oxo-5-alpha-steroid 4-dehydrogenase activity (IEA)

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-CH group of donors (IEA)

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (IEA)

polyprenol reductase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Srd5a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	28,553,298 - 28,570,808 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	17,727,310 - 17,745,225 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	17,727,418 - 17,744,780 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRD5A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	55,346,242 - 55,373,100 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	55,346,213 - 55,373,100 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	56,212,409 - 56,239,267 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	55,907,166 - 55,932,235 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	53,714,242 - 53,739,692 (+)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	52,161,384 - 52,188,230 (+)	NCBI		HuRef
CHM1_1	4	56,247,542 - 56,274,429 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	58,834,370 - 58,861,238 (+)	NCBI		T2T-CHM13v2.0

Srd5a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	76,285,296 - 76,303,350 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	76,288,118 - 76,303,351 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	76,140,273 - 76,155,503 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	76,140,271 - 76,155,504 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	76,569,302 - 76,584,496 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	77,215,052 - 77,230,246 (+)	NCBI		MGSCv36	mm8
Celera	5	73,411,924 - 73,427,131 (+)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI
cM Map	5	40.5	NCBI

Srd5a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	32,400,603 - 32,414,987 (-)	NCBI		GRCr8
mRatBN7.2	14	32,046,408 - 32,060,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	32,046,408 - 32,060,747 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	32,412,742 - 32,427,151 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	33,720,639 - 33,735,052 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	32,205,755 - 32,220,164 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	34,554,769 - 34,570,423 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	34,556,220 - 34,570,356 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	34,387,218 - 34,402,885 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	34,318,370 - 34,333,413 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	34,318,370 - 34,333,413 (-)	NCBI
Celera	14	31,347,467 - 31,361,593 (-)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

Srd5a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955447	15,578,661 - 15,588,218 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRD5A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	74,421,840 - 74,445,979 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	74,625,843 - 74,649,981 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	68,565,400 - 68,591,400 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	75,131,196 - 75,155,347 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	75,131,196 - 75,155,347 (-)	Ensembl	panpan1.1		panPan2

SRD5A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	47,627,854 - 47,643,116 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	47,627,913 - 47,642,566 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	47,585,282 - 47,601,064 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	48,238,814 - 48,254,620 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	48,238,759 - 48,253,443 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	47,914,061 - 47,929,821 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	47,442,811 - 47,458,595 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	48,391,087 - 48,406,872 (+)	NCBI		UU_Cfam_GSD_1.0

LOC100525350
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	42,024,352 - 42,049,209 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	44,131,945 - 44,156,754 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRD5A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	13,193,601 - 13,218,115 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	13,190,412 - 13,217,768 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666066	13,948,826 - 13,972,878 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srd5a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	14,089,900 - 14,104,408 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	14,087,772 - 14,104,348 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021722810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000016177 ⟹ ENSSTOP00000014482

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936482	17,727,310 - 17,745,225 (+)	Ensembl

RefSeq Acc Id:

XM_005320015 ⟹ XP_005320072

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	28,553,298 - 28,570,802 (-)	NCBI
SpeTri2.0	NW_004936482	17,727,420 - 17,744,780 (+)	NCBI

Sequence:

show sequence

CGCGCGGCGGGAGTGGCCGCTCCTCCGGGGCGGTGGCGGTGGCGCGGGATTGTGGACGCCGGGA
GCGCGGGCCATGGCTCCCTGGGCGGGGTCCGAGGCCTCGTCGCTGAACCCGCTGCGCGCGCTGT
GGCTGGCGCTGGCCGCCGCCTTCCTGCTGACCTTGCTGCTGCAGCTCGTGCCGCCCAGCCTGCT
CCCGGGCTGCGCGCTCTTCCAGGACCTGATCCGCTATGGGAAAACCAAGCTGGGGGGGCCTCGG
CGCCCGGCTGTCTGCCGGGCCTTTGAAGTCCCCAAGAGGTATTTTTCTCACTTCTACGTTATCT
CGGTGCTGTGGAATGGCTTCCTGCTTTGGTTCCTTACCCAGTCTCTGTTCCTGGGAGTACCTTT
TCCACAGTGGCTTCACCGTTTGCTCAGAATTCTTGGGGCAGCGCAGTTCCAAGGGGGTGAGCTG
GCACTGTCTGCCTTCTTAGTGCTCGTGTTCCTGTGGCTGCACAGCGTGCGGAGGCTCTTCGAGT
GCTTCTACGTCAGTGTCTTCTCCAACGCCGTGATTCACCTCGTGCAGTATTGTTTTGGACTCGT
CTACTACGTCCTGGTCGGCCTGACCGTGCTGAGCCAGGTGCCACTGGATGGCAGGAATGTCTAT
GTAATAGGGAAAAATCTGTTGATGCAAGCACGCTGGTTTCACATCCTGGGAATGATGATGTTCT
TCTGGTCATCTGCCCATCAGTATAAATGCCACGTCATTCTCGGCAATCTCAGAAAAAATAAAGC
AGGAGTGGTCATTCACTGCAACCATCGGATCCCATTTGGAGACTGGTTTGAATATGTTTCTTCC
CCTAACTACTTAGCAGAGCTGATGATCTACATTTCCATGGCTGTCACCTTTGGGTTCCACAATT
TAACTTGGTGGCTAGTGGTGACATATGTCTTCTTCAGCCAGGCCCTGTCTGCTTTCCTCAGCCA
CAAATTCTACAAAAGCAAATTTGTCTCCTACCCAAAGCATAGGAAAGCTTTCCTACCATTTTTG
TTTTGAGAGAACCTCAGTCATGAAGAAAGCAAGTTAGGTGACAAGTTCAATGCCTAGAGACTGT
GAGACCAAAGTGCACTTTCGGCAGAACTGTTTAAAATTCTTTGTTCCATAAATTCTTTACCAAG
TGAACAAAGCAATACCCTGGAGCAGATAAATCTTCAGAGTGTCTTCAAAGAAGAAATACTTCTG
GCAGACTTAGGGTTACCACCTCTGCTTTCTGCCATGCTTTACAAAGCCAACCAACAAATTAAAA
AGTAGACAAGATTTCTCCAAGCTGCTTCACAAGCACACTAACCAAGTCCAGACAGCTTCACACA
CATACACATGTACACCAAGAGGAGACAAGACTATCTGCAGCTGGAAAGCTTGTTAGGGAACAAT
GGACTGCACTAGATAGTGAGGGATATAGTAGGGGTTCAATAAATATTTGTAAAGTTCAATTATA
GCAGATGTAACATTTGAAAATAACATTAACATATAATTTGACACCAACCGTTTCAAAGAAAGAT
GAGTCGTTGGGGTTAATCTATATTGTCACGTATTGCACAAGAATCTCCAGTTATGAAACCATTT
GAAAAGTTACGAAATTTGAAAAGTTATGAAGTGAAGCCATTTCCACTCATCTCCCCTGCAAGTC
AGCCTAATAGAAAGTTTTAAAACTTACTTAATTCTTCTTTGACACTCCTTTCAAGAGAGTCCTT
TAAAAGCAAAAGCATTGAAAAATAAAATATTTTTATATTTATGCATAAAAAACCTTCTTTGAAC
TGATATGCTCTGAACCAGGTACTACTGAGACCTCCTTCAGCAGTAGTTATTCAAATTGGATAAT
GTCACCTGAGTGCATTTCAACTAACAGAATGAATTTGGAGATATCTAGGAATAAAGTTTACACT
TTAAATTGCTTATGCTAAAGACAATATCCATGCTTAAATCAAAGGGAAATAAATGCATAGCATG
AAAGGAAAACTAAATCTTTAACAATAATACTACAGCCTGAGCACATTCACACAGCATAGGACTT
TCTAGCTCCTGGGTGAGATATTAACTTACTCCTTTTATGCAAATGTTGCATTATAGTCCACTAA
GTGCACTTATTTGTGCCTTGCTAAGGGGGAAAGAATCTCATTATTAATCAGACACATCAAAAGC
ATAGTCTAATAGTATGTTCCCCAGCTTCATCCTGGGTAGTAAGCCTAGATTAAAACCAGTTCCT
TTAAATCTCACTTTAAATACATGCATAGCAAAACACATCCTAAAGTTCTTTCATTCATTCTGAT
GTCACATTTTCTCTCCCATCAATCAAATACCACTTACTGAGCCCATTGCTCAGTCTGTTCAAAT
ACATGACATATTCATTCCATTTGCCAGTTGGAATTTGCTGTTCTCCAAATCAGGACCCTGGAAC
AAAAGCATTTCTACTTGGAAATGTAAAGCATATTTTAGGTTGGTTTTAATCTCCACACAAATAG
GCTATGTAATTTTAAATAAATTATTGAGGGAAAAGTTGTATTTTACTTTAGCATGCAATTTTAT
ACCTAGGATCTGACTGATGTTCTGGAGTCTTACTGTACTTGGAAGTAAAATAGTGAGCAGATGC
CCACGACGTATTCTGTCGGGAACTATGAGAAAGCATTGCCGTTTCCTGTTCCTGTCCTTGCTGT
CCCTTGCACACTGTCCCCTGTCTCTTACTTTCCCTTCTCTTCTGTGCCCGAACAATGCATTTCT
AGTTGGAAATTAAAAAGGAAATAGTGATGTCTTCAAAGGAGTTTCAGACAAACTAGCATGGCTT
TTGGTGAAAGCTTAACTGATGGTGCATGATTGAGAATTGTGAGCAGCTAGAGATGTGGCTCCCT
GGTAGAGCAGAAGGCCCTGGGTCATCTCCAGCACTGGAAAAAATAAAAAGAAAGAAAGGAATGG
GAAAAAAAAATGTGCTGTGCTTCTAAGGGCAGAATTAGTGCTGTTTTGTGCAAGTGAAAATAAT
TCTGTGCCTCTAAGGGGAGAGCCCACAAAGACTCACAAATTCTTCACAAGAATGACCCAGAAAT
AGCGTGGAGGTGGAGATTCTTGACTTTCCTGTGTGAATAGCCTTGACCTTTTATTCTAGGCTGC
CATCAAGGTAAGGAAATGATACTGAACTACCTCAAAGCAGCAGTCTCTGAATTCACTACTGACT
ATTCAAAGTATGTTGAAAGTTTCCTTTGTTTTTGACAAGTCTCCAAGTTCTAGCTCATCCCACA
TACTAACATTTGCTTACAGTAAGCATGAATTACTTTGTCTCCATAAAGCTGTGTTCTGTATTAT
ATTTTTAACTCAATGAGTAGTTACTGCTAGAATTCCTACCTAAACAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_021722810 ⟹ XP_021578485

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	28,553,298 - 28,570,808 (-)	NCBI
SpeTri2.0	NW_004936482	17,727,418 - 17,744,780 (+)	NCBI

Sequence:

show sequence

GGCGCGCGGCGGGAGTGGCCGCTCCTCCGGGGCGGTGGCGGTGGCGCGGGATTGTGGACGCCGG
GAGCGCGGGCCATGGCTCCCTGGGCGGGGTCCGAGGCCTCGTCGCTGAACCCGCTGCGCGCGCT
GTGGCTGGCGCTGGCCGCCGCCTTCCTGCTGACCTTGCTGCTGCAGCTCGTGCCGCCCAGCCTG
CTCCCGGGCTGCGCGCTCTTCCAGGACCTGATCCGCTATGGGAAAACCAAGCTGGGGGGGCCTC
GGCGCCCGGCTGTCTGCCGGGCCTTTGAAGTCCCCAAGAGGTATTTTTCTCACTTCTACGTTAT
CTCGGTGCTGTGGAATGGCTTCCTGCTTTGGTTCCTTACCCAGTCTCTGTTCCTGGGAGTACCT
TTTCCACAGTGGCTTCACCGTTTGCTCAGAATTCTTGGGGCAGCGCAGTTCCAAGGGGGTGAGC
TGGCACTGTCTGCCTTCTTAGTGCTCGTGTTCCTGTGGCTGCACAGCGTGCGGAGGCTCTTCGA
GTGCTTCTACGTCAGTGTCTTCTCCAACGCCGTGATTCACCTCGTGCAGTATTGTTTTGGACTC
GTCTACTACGTCCTGGTCGGCCTGACCGTGCTGAGCCAGGTGCCACTGGATGGCAGGAATGGAG
TGGTCATTCACTGCAACCATCGGATCCCATTTGGAGACTGGTTTGAATATGTTTCTTCCCCTAA
CTACTTAGCAGAGCTGATGATCTACATTTCCATGGCTGTCACCTTTGGGTTCCACAATTTAACT
TGGTGGCTAGTGGTGACATATGTCTTCTTCAGCCAGGCCCTGTCTGCTTTCCTCAGCCACAAAT
TCTACAAAAGCAAATTTGTCTCCTACCCAAAGCATAGGAAAGCTTTCCTACCATTTTTGTTTTG
AGAGAACCTCAGTCATGAAGAAAGCAAGTTAGGTGACAAGTTCAATGCCTAGAGACTGTGAGAC
CAAAGTGCACTTTCGGCAGAACTGTTTAAAATTCTTTGTTCCATAAATTCTTTACCAAGTGAAC
AAAGCAATACCCTGGAGCAGATAAATCTTCAGAGTGTCTTCAAAGAAGAAATACTTCTGGCAGA
CTTAGGGTTACCACCTCTGCTTTCTGCCATGCTTTACAAAGCCAACCAACAAATTAAAAAGTAG
ACAAGATTTCTCCAAGCTGCTTCACAAGCACACTAACCAAGTCCAGACAGCTTCACACACATAC
ACATGTACACCAAGAGGAGACAAGACTATCTGCAGCTGGAAAGCTTGTTAGGGAACAATGGACT
GCACTAGATAGTGAGGGATATAGTAGGGGTTCAATAAATATTTGTAAAGTTCAATTATAGCAGA
TGTAACATTTGAAAATAACATTAACATATAATTTGACACCAACCGTTTCAAAGAAAGATGAGTC
GTTGGGGTTAATCTATATTGTCACGTATTGCACAAGAATCTCCAGTTATGAAACCATTTGAAAA
GTTACGAAATTTGAAAAGTTATGAAGTGAAGCCATTTCCACTCATCTCCCCTGCAAGTCAGCCT
AATAGAAAGTTTTAAAACTTACTTAATTCTTCTTTGACACTCCTTTCAAGAGAGTCCTTTAAAA
GCAAAAGCATTGAAAAATAAAATATTTTTATATTTATGCATAAAAAACCTTCTTTGAACTGATA
TGCTCTGAACCAGGTACTACTGAGACCTCCTTCAGCAGTAGTTATTCAAATTGGATAATGTCAC
CTGAGTGCATTTCAACTAACAGAATGAATTTGGAGATATCTAGGAATAAAGTTTACACTTTAAA
TTGCTTATGCTAAAGACAATATCCATGCTTAAATCAAAGGGAAATAAATGCATAGCATGAAAGG
AAAACTAAATCTTTAACAATAATACTACAGCCTGAGCACATTCACACAGCATAGGACTTTCTAG
CTCCTGGGTGAGATATTAACTTACTCCTTTTATGCAAATGTTGCATTATAGTCCACTAAGTGCA
CTTATTTGTGCCTTGCTAAGGGGGAAAGAATCTCATTATTAATCAGACACATCAAAAGCATAGT
CTAATAGTATGTTCCCCAGCTTCATCCTGGGTAGTAAGCCTAGATTAAAACCAGTTCCTTTAAA
TCTCACTTTAAATACATGCATAGCAAAACACATCCTAAAGTTCTTTCATTCATTCTGATGTCAC
ATTTTCTCTCCCATCAATCAAATACCACTTACTGAGCCCATTGCTCAGTCTGTTCAAATACATG
ACATATTCATTCCATTTGCCAGTTGGAATTTGCTGTTCTCCAAATCAGGACCCTGGAACAAAAG
CATTTCTACTTGGAAATGTAAAGCATATTTTAGGTTGGTTTTAATCTCCACACAAATAGGCTAT
GTAATTTTAAATAAATTATTGAGGGAAAAGTTGTATTTTACTTTAGCATGCAATTTTATACCTA
GGATCTGACTGATGTTCTGGAGTCTTACTGTACTTGGAAGTAAAATAGTGAGCAGATGCCCACG
ACGTATTCTGTCGGGAACTATGAGAAAGCATTGCCGTTTCCTGTTCCTGTCCTTGCTGTCCCTT
GCACACTGTCCCCTGTCTCTTACTTTCCCTTCTCTTCTGTGCCCGAACAATGCATTTCTAGTTG
GAAATTAAAAAGGAAATAGTGATGTCTTCAAAGGAGTTTCAGACAAACTAGCATGGCTTTTGGT
GAAAGCTTAACTGATGGTGCATGATTGAGAATTGTGAGCAGCTAGAGATGTGGCTCCCTGGTAG
AGCAGAAGGCCCTGGGTCATCTCCAGCACTGGAAAAAATAAAAAGAAAGAAAGGAATGGGAAAA
AAAAATGTGCTGTGCTTCTAAGGGCAGAATTAGTGCTGTTTTGTGCAAGTGAAAATAATTCTGT
GCCTCTAAGGGGAGAGCCCACAAAGACTCACAAATTCTTCACAAGAATGACCCAGAAATAGCGT
GGAGGTGGAGATTCTTGACTTTCCTGTGTGAATAGCCTTGACCTTTTATTCTAGGCTGCCATCA
AGGTAAGGAAATGATACTGAACTACCTCAAAGCAGCAGTCTCTGAATTCACTACTGACTATTCA
AAGTATGTTGAAAGTTTCCTTTGTTTTTGACAAGTCTCCAAGTTCTAGCTCATCCCACATACTA
ACATTTGCTTACAGTAAGCATGAATTACTTTGTCTCCATAAAGCTGTGTTCTGTATTATATTTT
TAACTCAATGAGTAGTTACTGCTAGAATTCCTACCTAAACAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005320072	(Get FASTA)	NCBI Sequence Viewer
	XP_021578485	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014482.2
GenBank Protein	KAG3276604	(Get FASTA)	NCBI Sequence Viewer
	KAG3276605	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005320072 ⟸ XM_005320015
- Peptide Label:	isoform X1
- UniProtKB:	I3MR19 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPWAGSEASSLNPLRALWLALAAAFLLTLLLQLVPPSLLPGCALFQDLIRYGKTKLGGPRRPA VCRAFEVPKRYFSHFYVISVLWNGFLLWFLTQSLFLGVPFPQWLHRLLRILGAAQFQGGELALS AFLVLVFLWLHSVRRLFECFYVSVFSNAVIHLVQYCFGLVYYVLVGLTVLSQVPLDGRNVYVIG KNLLMQARWFHILGMMMFFWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNY LAELMIYISMAVTFGFHNLTWWLVVTYVFFSQALSAFLSHKFYKSKFVSYPKHRKAFLPFLF hide sequence

RefSeq Acc Id:

XP_021578485 ⟸ XM_021722810

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAPWAGSEASSLNPLRALWLALAAAFLLTLLLQLVPPSLLPGCALFQDLIRYGKTKLGGPRRPA
VCRAFEVPKRYFSHFYVISVLWNGFLLWFLTQSLFLGVPFPQWLHRLLRILGAAQFQGGELALS
AFLVLVFLWLHSVRRLFECFYVSVFSNAVIHLVQYCFGLVYYVLVGLTVLSQVPLDGRNGVVIH
CNHRIPFGDWFEYVSSPNYLAELMIYISMAVTFGFHNLTWWLVVTYVFFSQALSAFLSHKFYKS
KFVSYPKHRKAFLPFLF

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RefSeq Acc Id:

ENSSTOP00000014482 ⟸ ENSSTOT00000016177

Protein Domains

Steroid 5-alpha reductase C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016177	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016177.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.1630	UniProtKB/TrEMBL
InterPro	3-oxo-5_a-steroid_4-DH_C	UniProtKB/TrEMBL
	Dfg10/SRD5A3	UniProtKB/TrEMBL
NCBI Gene	Srd5a3	ENTREZGENE
PANTHER	POLYPRENOL REDUCTASE	UniProtKB/TrEMBL
	PTHR14624	UniProtKB/TrEMBL
Pfam	Steroid_dh	UniProtKB/TrEMBL
PROSITE	S5A_REDUCTASE	UniProtKB/TrEMBL
UniProt	I3MR19	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM