Flcn (folliculin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Flcn (folliculin) Ictidomys tridecemlineatus
Analyze
Symbol: Flcn
Name: folliculin
RGD ID: 12733694
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cell-cell junction assembly (ortholog); cellular response to amino acid starvation (ortholog); cellular response to starvation (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); colon cancer (ortholog); FOUND IN cell-cell contact zone (ortholog); centrosome (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: folliculin, transcript variant X1; folliculin, transcript variant X2; folliculin, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell-cell junction assembly  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to starvation  (ISO)
energy homeostasis  (ISO)
hemopoiesis  (ISO)
in utero embryonic development  (ISO)
lysosome localization  (ISO)
negative regulation of ATP biosynthetic process  (ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in kidney development  (ISO)
negative regulation of cellular respiration  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitochondrial DNA metabolic process  (ISO)
negative regulation of mitochondrion organization  (ISO)
negative regulation of muscle tissue development  (ISO)
negative regulation of post-translational protein modification  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of TOR signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of cytokinesis  (ISO)
regulation of histone acetylation  (ISO)
regulation of pro-B cell differentiation  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of Ras protein signal transduction  (ISO)
regulation of TOR signaling  (ISO)
TOR signaling  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1717,212,212 - 17,237,188 (-)EnsemblGRCh38hg38GRCh38
GRCh381717,206,946 - 17,237,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371717,115,526 - 17,140,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,056,251 - 17,081,221 (-)NCBINCBI36hg18NCBI36
Celera1718,055,113 - 18,080,089 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1716,868,444 - 16,893,256 (-)NCBIHuRef
CHM1_11717,125,252 - 17,150,222 (-)NCBICHM1_1
Flcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)Ensembl
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBImm8
MGSCv361160,328,330 - 60,346,353 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
Flcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,588,621 - 44,607,808 (-)NCBI
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
Flcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11738,988,520 - 39,013,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,988,518 - 39,013,160 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01734,057,127 - 34,081,637 (+)NCBIMhudiblu_PPA_v0panPan3
FLCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,176,093 - 42,195,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,176,291 - 42,195,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,316,328 - 42,335,442 (+)NCBI
ROS_Cfam_1.0542,284,487 - 42,304,049 (+)NCBI
UMICH_Zoey_3.1542,251,943 - 42,271,053 (+)NCBI
UNSW_CanFamBas_1.0542,199,268 - 42,218,373 (+)NCBI
UU_Cfam_GSD_1.0542,391,398 - 42,410,513 (+)NCBI
FLCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11261,029,186 - 61,045,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,245,840 - 16,271,465 (-)NCBI
ChlSab1.1 Ensembl1616,245,715 - 16,267,698 (-)Ensembl
Vero_WHO_p1.0NW_0236660594,642,225 - 4,670,076 (+)NCBI
Flcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248494,157,683 - 4,179,724 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005339446   ⟹   XP_005339503
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560261,965,874 - 61,986,098 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013364815   ⟹   XP_013220269
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560261,965,873 - 61,985,176 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021736027   ⟹   XP_021591702
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560261,966,026 - 61,985,176 (+)NCBI
SpeTri2.0NW_004936741881,150 - 901,199 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013220269   ⟸   XM_013364815
- UniProtKB: I3MJ54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005339503   ⟸   XM_005339446
- UniProtKB: I3MJ54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591702   ⟸   XM_021736027
- Sequence:
Protein Domains
uDENN FLCN/SMCR8-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012424 ENTREZGENE
Ensembl Protein ENSSTOP00000011141 ENTREZGENE
NCBI Gene Flcn ENTREZGENE
UniProt I3MJ54 ENTREZGENE