Tbx5 (T-box transcription factor 5) - Rat Genome Database

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Gene: Tbx5 (T-box transcription factor 5) Ictidomys tridecemlineatus
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Symbol: Tbx5
Name: T-box transcription factor 5
RGD ID: 12733278
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN atrial septum development (ortholog); atrial septum morphogenesis (ortholog); atrioventricular bundle cell differentiation (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: T-box 5; T-box 5, transcript variant X1; T-box 5, transcript variant X2; T-box transcription factor TBX5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBI
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial septum development  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular bundle cell differentiation  (ISO)
atrioventricular node cell development  (ISO)
atrioventricular node cell fate commitment  (ISO)
atrioventricular valve morphogenesis  (ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (ISO)
bundle of His development  (ISO)
cardiac left ventricle formation  (ISO)
cardiac muscle cell differentiation  (ISO)
cell-cell signaling  (ISO)
cell-cell signaling involved in cardiac conduction  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endocardial cushion development  (ISO)
forelimb morphogenesis  (ISO)
heart development  (ISO)
lung development  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
pattern specification process  (ISO)
pericardium development  (ISO)
positive regulation of cardiac conduction  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of secondary heart field cardioblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (ISO)
regulation of transcription, DNA-templated  (ISO)
transdifferentiation  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Tbx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBI
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12114,353,911 - 114,408,442 (-)EnsemblGRCh38hg38GRCh38
GRCh3812114,353,911 - 114,408,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712114,791,716 - 114,846,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,276,118 - 113,330,630 (-)NCBINCBI36hg18NCBI36
Celera12114,419,103 - 114,473,633 (-)NCBI
Cytogenetic Map12q24.21NCBI
HuRef12111,801,135 - 111,855,628 (-)NCBIHuRef
CHM1_112114,759,933 - 114,814,388 (-)NCBICHM1_1
Tbx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,934,581 - 120,023,285 (+)NCBIGRCm39mm39
GRCm39 Ensembl5119,970,733 - 120,023,284 (+)Ensembl
GRCm385119,796,514 - 119,885,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,832,668 - 119,885,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,284,672 - 120,335,227 (+)NCBIGRCm37mm9NCBIm37
MGSCv365120,095,280 - 120,145,092 (+)NCBImm8
Celera5116,903,647 - 116,978,836 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.42NCBI
Tbx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21236,686,344 - 36,739,253 (-)NCBI
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01242,059,688 - 42,148,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01243,909,016 - 43,998,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,956,658 - 38,004,255 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11237,820,045 - 37,867,643 (-)NCBI
Celera1238,362,373 - 38,409,445 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tbx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545516,132,975 - 16,217,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545516,133,130 - 16,217,894 (+)NCBIChiLan1.0ChiLan1.0
TBX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112115,336,267 - 115,389,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,333,609 - 115,389,739 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012111,954,222 - 112,009,261 (-)NCBIMhudiblu_PPA_v0panPan3
TBX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,462,541 - 11,549,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,463,653 - 11,506,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,520,894 - 11,607,938 (-)NCBI
ROS_Cfam_1.02611,714,458 - 11,801,523 (-)NCBI
UMICH_Zoey_3.12611,682,098 - 11,768,911 (-)NCBI
UNSW_CanFamBas_1.02611,744,240 - 11,831,307 (-)NCBI
UU_Cfam_GSD_1.02611,794,191 - 11,881,084 (-)NCBI
TBX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,773,605 - 37,824,400 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,772,205 - 37,826,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,161,963 - 40,260,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,638,694 - 109,696,619 (-)NCBI
ChlSab1.1 Ensembl11109,638,715 - 109,689,177 (-)Ensembl
Vero_WHO_p1.0NW_023666037135,422,975 - 135,477,375 (+)NCBI
Tbx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474718,307,294 - 18,348,040 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005329642   ⟹   XP_005329699
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBI
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021729338   ⟹   XP_021585013
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365587,415,279 - 7,454,897 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005329699 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3278969 (Get FASTA)   NCBI Sequence Viewer  
  KAG3278970 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005329699   ⟸   XM_005329642
- UniProtKB: I3M1W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021585013   ⟸   XM_021729338
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003231 ENTREZGENE
Ensembl Protein ENSSTOP00000002875 ENTREZGENE
NCBI Gene Tbx5 ENTREZGENE
UniProt I3M1W0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 Tbx5  T-box transcription factor 5  Tbx5  T-box 5  Symbol and/or name change 5135510 APPROVED