Tbx5 (T-box transcription factor 5) - Rat Genome Database

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Gene: Tbx5 (T-box transcription factor 5) Ictidomys tridecemlineatus
Analyze
Symbol: Tbx5
Name: T-box transcription factor 5
RGD ID: 12733278
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN atrial septum development (ortholog); atrial septum morphogenesis (ortholog); atrioventricular valve morphogenesis (ortholog); ASSOCIATED WITH aortic valve disease 2 (ortholog); atrial fibrillation (ortholog); atrial heart septal defect 1 (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 5; T-box 5, transcript variant X1; T-box 5, transcript variant X2; T-box transcription factor TBX5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365587,408,222 - 7,454,901 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial septum development  (IEA,ISO)
atrial septum morphogenesis  (IEA,ISO)
atrioventricular bundle cell differentiation  (IEA)
atrioventricular node cell development  (IEA)
atrioventricular node cell fate commitment  (IEA)
atrioventricular valve morphogenesis  (IEA,ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA,ISO)
bundle of His development  (IEA,ISO)
cardiac left ventricle formation  (IEA)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle cell proliferation  (IEA,ISO)
cell fate specification  (IEA)
cell-cell signaling  (IEA,ISO)
developmental process  (IEA)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
forelimb morphogenesis  (IEA,ISO)
heart development  (IEA,ISO)
lung development  (IEA,ISO)
morphogenesis of an epithelium  (IEA,ISO)
negative regulation of cardiac muscle cell proliferation  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
pattern specification process  (IEA,ISO)
pericardium development  (IEA)
positive regulation of cardiac conduction  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cardioblast differentiation  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gap junction assembly  (IEA)
positive regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to aldosterone  (ISO)
sinoatrial node development  (IEA)
transcription by RNA polymerase II  (IEA,ISO)
transdifferentiation  (ISO)
ventricular cardiac muscle tissue development  (IEA,ISO)
ventricular septum development  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tbx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365587,408,222 - 7,454,901 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812114,353,911 - 114,408,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12114,353,911 - 114,408,442 (-)EnsemblGRCh38hg38GRCh38
GRCh3712114,791,716 - 114,846,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,276,118 - 113,330,630 (-)NCBINCBI36Build 36hg18NCBI36
Celera12114,419,103 - 114,473,633 (-)NCBICelera
Cytogenetic Map12q24.21NCBI
HuRef12111,801,135 - 111,855,628 (-)NCBIHuRef
CHM1_112114,759,933 - 114,814,388 (-)NCBICHM1_1
T2T-CHM13v2.012114,330,644 - 114,385,180 (-)NCBIT2T-CHM13v2.0
Tbx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,934,581 - 120,023,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5119,970,733 - 120,023,284 (+)EnsemblGRCm39 Ensembl
GRCm385119,796,514 - 119,885,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,832,668 - 119,885,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,284,672 - 120,335,227 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,095,280 - 120,145,092 (+)NCBIMGSCv36mm8
Celera5116,903,647 - 116,978,836 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.42NCBI
Tbx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81242,342,926 - 42,399,723 (-)NCBIGRCr8
mRatBN7.21236,686,344 - 36,739,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,688,014 - 36,734,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,865,094 - 37,912,212 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,478,894 - 38,526,001 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01237,531,397 - 37,578,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,059,688 - 42,148,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,909,016 - 43,998,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,956,658 - 38,004,255 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,820,045 - 37,867,643 (-)NCBI
Celera1238,362,373 - 38,409,445 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tbx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545516,132,975 - 16,217,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545516,133,130 - 16,217,894 (+)NCBIChiLan1.0ChiLan1.0
TBX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210122,438,882 - 122,492,953 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112122,435,278 - 122,485,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012111,954,222 - 112,009,261 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112115,336,267 - 115,389,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,333,609 - 115,389,739 (-)Ensemblpanpan1.1panPan2
TBX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,462,541 - 11,549,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,463,653 - 11,506,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,520,894 - 11,607,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02611,714,458 - 11,801,523 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2611,714,461 - 11,760,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12611,682,098 - 11,768,911 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02611,744,240 - 11,831,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02611,794,191 - 11,881,084 (-)NCBIUU_Cfam_GSD_1.0
TBX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,774,171 - 37,825,401 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,772,205 - 37,826,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,161,963 - 40,260,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,638,694 - 109,696,619 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11109,638,715 - 109,689,177 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037135,422,975 - 135,477,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474718,307,294 - 18,348,040 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474718,307,294 - 18,348,040 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003221   ⟹   ENSSTOP00000002875
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365587,408,222 - 7,454,901 (+)Ensembl
RefSeq Acc Id: XM_005329642   ⟹   XP_005329699
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBI
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005329699 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002875.3
GenBank Protein KAG3278969 (Get FASTA)   NCBI Sequence Viewer  
  KAG3278970 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005329699   ⟸   XM_005329642
- UniProtKB: I3M1W0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000002875   ⟸   ENSSTOT00000003221
Protein Domains
T-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003231 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003221.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene Tbx5 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX5 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt I3M1W0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 Tbx5  T-box transcription factor 5  Tbx5  T-box 5  Symbol and/or name change 5135510 APPROVED