Rhbdd2 (rhomboid domain containing 2)

Gene: Rhbdd2 (rhomboid domain containing 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Rhbdd2

Name:

rhomboid domain containing 2

RGD ID:

12732729

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); ASSOCIATED WITH Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ortholog); genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN Golgi apparatus (inferred); Golgi membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

rhomboid domain-containing protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,673,056 - 131,683,741 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,353,317 - 2,361,927 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,352,825 - 2,362,995 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

Golgi apparatus (IEA)

Golgi membrane (IEA)

membrane (IEA)

nucleoplasm (IEA)

perinuclear region of cytoplasm (IEA)

Molecular Function

protein binding (ISO)

serine-type endopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rhbdd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,673,056 - 131,683,741 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,353,317 - 2,361,927 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,352,825 - 2,362,995 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHBDD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	75,879,034 - 75,888,926 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	75,842,602 - 75,888,926 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	75,508,352 - 75,518,244 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	75,346,253 - 75,356,180 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	75,152,916 - 75,162,890	NCBI
Celera	7	70,376,144 - 70,386,071 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	70,594,634 - 70,604,561 (+)	NCBI		HuRef
CHM1_1	7	75,438,417 - 75,448,344 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	77,166,165 - 77,176,057 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	74,841,381 - 74,851,308 (+)	NCBI

Rhbdd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,661,508 - 135,675,230 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,661,472 - 135,675,302 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,632,654 - 135,646,376 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,632,618 - 135,646,448 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	136,108,524 - 136,122,246 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,917,281 - 135,931,003 (+)	NCBI		MGSCv36	mm8
Celera	5	132,639,255 - 132,652,977 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.31	NCBI

Rhbdd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,680,206 - 26,690,926 (-)	NCBI		GRCr8
mRatBN7.2	12	21,043,605 - 21,054,305 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,043,608 - 21,054,289 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,186,226 - 22,196,171 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	22,798,568 - 22,808,513 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	21,865,030 - 21,874,975 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,091,132 - 24,102,081 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,092,004 - 24,102,084 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,088,695 - 26,099,385 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,198,539 - 22,208,465 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	22,185,850 - 22,195,776 (-)	NCBI
Celera	12	22,806,820 - 22,816,746 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Rhbdd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,652,816 - 14,668,298 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,652,995 - 14,666,155 (+)	NCBI	ChiLan1.0	ChiLan1.0

RHBDD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	94,065,827 - 94,075,810 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	142,330,465 - 142,340,419 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	68,132,256 - 68,142,198 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,328,777 - 82,338,401 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,328,777 - 82,338,401 (+)	Ensembl	panpan1.1		panPan2

RHBDD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	7,218,796 - 7,230,949 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	7,218,853 - 7,232,321 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,915,509 - 8,927,680 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	7,039,491 - 7,051,679 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	7,039,486 - 7,051,679 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	7,008,891 - 7,021,069 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,972,369 - 6,984,538 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	7,135,572 - 7,147,755 (+)	NCBI		UU_Cfam_GSD_1.0

RHBDD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,299,209 - 10,309,622 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,299,201 - 10,329,638 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RHBDD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,126,934 - 10,134,740 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	10,126,901 - 10,135,061 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	6,288,892 - 6,298,937 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rhbdd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,698,665 - 14,712,382 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,698,769 - 14,709,994 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013360009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000026857 ⟹ ENSSTOP00000017470

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936543	2,353,317 - 2,361,927 (-)	Ensembl

RefSeq Acc Id:

XM_013360009 ⟹ XP_013215463

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,673,056 - 131,683,741 (+)	NCBI
SpeTri2.0	NW_004936543	2,352,825 - 2,362,995 (-)	NCBI

Sequence:

show sequence

CATTTATACTTGGAATTTCAGTTTCGGAAGTACTCAACAAATAATGAAGTACTCTTCAGATAAT
GAAGCCTTCCGGAGACGGCCTGACAGTTTACAGGTTGGTGACCTACATCTTTGTCTATGAGAAC
CCAGTCTCCCTGCTCTGCGGTGCTGTCATCATCTGGCGCTTTGCTGGCAATTTTGAGAGAACTG
TGGGCACCGTCCGCCACTGTTTCTTCACCTTGATCTTCGCCCTCTTCTCCGCGATCATCTTCCT
GTCATTTGAAGCTGTATCGTCACTGTCAAAGCTGGGGGAAGTGGAGGATGCCAGAGGTTTCACC
CCGGTGGCCTTTGCCATGCTGGGAGTCACCTCTGTCCGCTCTCGGATGAAGAGGGCCCTGGTGT
TTGGTGTGGTGGTGCCCTCGGTGCTGGTGCCCTGGCTCCTGCTGGCTGCCTCTTGGCTCATCCC
CCAGACCTCCTTCCTGAGCAACATCTGTGGCCTTCTGGTCGGGCTGGCGTATGGTGTCACCTAC
TGCCACTCCATCGACCTCTCAGAGCAAGTGGCACTGAAGCTCGACCAGAAGTTCCCCTTCAGCC
TCATGAGGAGGGTCTCCGTGTTCAAGTACATCTCCGGGTCTTCAGCCGAGAGAAGGGCTGCCCA
GAGCCGGAGGCTGAACCCTGTGCCTGGCTCCTACCCCACACAGAGCTGCCATCCTCATCTGTCT
CCAAACCACCCTGTCACCCAGATGCAGCAAGCCAGCGGCCAGAAACTGGCCTCCTGGCCAGCCA
TCCCTGGGCACATGCCCAGCCTGCCCCCGTACCAGCCCACCTCCGGCCTGTGTTATGTGCAGAA
CCACTTTGGCCCGAACCCTAACTCCTCCAGCGTCTACCCGGCTTCTGTGGGCACCTCCATGGGG
GTCCAGCCCCCTGCCCCCGTCAGCTGCCCTGGCACAGTGTATTCTGGGACCCTTGGCACCCCAG
GGGCTGCAGGCTCCAAGGAGTCCTCCAGGGTCACCATGCCCTGAGAGAACATTTAGGGAAGACA
CCTCACGTCTCGGCCTTCTGAGGAAGGTCCTGTCAGCCGATTTTCATGACAAAACTTATTTATT
GAATACCTCCTGTGCCAGGCCGTGTCGAGTACCTTGATACATGTCCGTTTCCACCCCCTTCGTG
CTCCCATCGGCTCTGTGAAGTAGTTTACACAGACACTCTGACATCATGGGATCCTGTGGCCCTG
GTGGCCCAGCTGGGGTTCCTCGCTCCTGGCTCAGGGCGCCTCCTAGAGGACATGGGAGGGAAGG
GCAGCTGTCGGGCTGCTGATGGCTCTCCAGCACCACCTTCCTTCCTGTCTCTACTCTGCACACG
CTCTGTCCCCTGCAGTGTCCCTGTGTCTGTGCTGGGCAGCCCCCAGGCCTCTGTAGTAAGTCTC
CCCCAGTCACCCGCACCCAGACTCAGGGCCCAGCTGCAGTGACCTGTGTCATGTCCTTGACCTT
TGTATAAAGAACCAGCCTCCAACCTGCC

hide sequence

RefSeq Acc Id:

XM_040277376 ⟹ XP_040133310

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,673,530 - 131,683,741 (+)	NCBI

RefSeq Acc Id:

XM_040277377 ⟹ XP_040133311

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,673,530 - 131,683,741 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013215463	(Get FASTA)	NCBI Sequence Viewer
	XP_040133310	(Get FASTA)	NCBI Sequence Viewer
	XP_040133311	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017470.2
GenBank Protein	KAG3259822	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013215463 ⟸ XM_013360009
- Peptide Label:	isoform X1
- UniProtKB:	I3MZC4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPSGDGLTVYRLVTYIFVYENPVSLLCGAVIIWRFAGNFERTVGTVRHCFFTLIFALFSAIIF LSFEAVSSLSKLGEVEDARGFTPVAFAMLGVTSVRSRMKRALVFGVVVPSVLVPWLLLAASWLI PQTSFLSNICGLLVGLAYGVTYCHSIDLSEQVALKLDQKFPFSLMRRVSVFKYISGSSAERRAA QSRRLNPVPGSYPTQSCHPHLSPNHPVTQMQQASGQKLASWPAIPGHMPSLPPYQPTSGLCYVQ NHFGPNPNSSSVYPASVGTSMGVQPPAPVSCPGTVYSGTLGTPGAAGSKESSRVTMP hide sequence

RefSeq Acc Id:	XP_040133311 ⟸ XM_040277377
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040133310 ⟸ XM_040277376
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000017470 ⟸ ENSSTOT00000026857

Protein Domains

Peptidase S54 rhomboid

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023795	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026857.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1540.10	UniProtKB/TrEMBL
InterPro	Peptidase_S54_rhomboid_dom	UniProtKB/TrEMBL
	Rhomboid-like_sf	UniProtKB/TrEMBL
NCBI Gene	Rhbdd2	ENTREZGENE
PANTHER	RHOMBOID DOMAIN-CONTAINING PROTEIN 2	UniProtKB/TrEMBL
	RHOMBOID-RELATED PROTEIN	UniProtKB/TrEMBL
Pfam	Rhomboid	UniProtKB/TrEMBL
Superfamily-SCOP	SSF144091	UniProtKB/TrEMBL
UniProt	I3MZC4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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