LOC101967158 (serine palmitoyltransferase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: LOC101967158 (serine palmitoyltransferase 2) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101967158 (Ensembl: SPTLC2)
Name: serine palmitoyltransferase 2 (Ensembl:serine palmitoyltransferase long chain base subunit 2)
RGD ID: 12730239
Description: ENCODES a protein that exhibits acyltransferase activity (inferred); pyridoxal phosphate binding (inferred); serine C-palmitoyltransferase activity (inferred); INVOLVED IN response to immobilization stress (ortholog); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); COVID-19 (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred); membrane (inferred); serine palmitoyltransferase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ism2; isthmin 2; isthmin-2; serine palmitoyltransferase long chain base subunit 2; Sptlc2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,664,744 - 25,778,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,315,715 - 6,419,882 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049364886,289,833 - 6,296,849 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,313,189 - 6,404,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101967158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,664,744 - 25,778,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,315,715 - 6,419,882 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049364886,289,833 - 6,296,849 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,313,189 - 6,404,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTLC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,505,997 - 77,616,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,505,997 - 77,616,637 (-)EnsemblGRCh38hg38GRCh38
GRCh371477,972,340 - 78,082,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361477,043,023 - 77,152,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 341477,043,024 - 77,152,863NCBI
Celera1458,011,851 - 58,121,636 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1458,138,337 - 58,249,054 (-)NCBIHuRef
CHM1_11477,911,814 - 78,022,586 (-)NCBICHM1_1
T2T-CHM13v2.01471,715,382 - 71,825,999 (-)NCBIT2T-CHM13v2.0
Sptlc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,351,832 - 87,435,129 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,351,832 - 87,435,129 (-)EnsemblGRCm39 Ensembl
GRCm381287,305,058 - 87,388,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,305,058 - 87,388,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371288,648,839 - 88,729,180 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361288,196,992 - 88,277,333 (-)NCBIMGSCv36mm8
Celera1288,772,417 - 88,852,773 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.52NCBI
Sptlc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,679,623 - 112,762,470 (-)NCBIGRCr8
mRatBN7.26106,948,682 - 107,031,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,950,949 - 107,031,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6107,116,961 - 107,199,840 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,415,779 - 107,498,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,785,468 - 106,868,346 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,334,408 - 111,417,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,339,136 - 111,417,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,616,251 - 120,699,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,546,037 - 111,622,959 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16111,245,978 - 111,626,585 (-)NCBI
Celera6104,771,427 - 104,849,755 (-)NCBICelera
Cytogenetic Map6q31NCBI
Sptlc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,385,431 - 1,491,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,385,431 - 1,491,534 (-)NCBIChiLan1.0ChiLan1.0
SPTLC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,591,247 - 78,702,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,807,751 - 77,918,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01458,066,123 - 58,170,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11477,266,545 - 77,370,663 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1477,266,545 - 77,370,663 (-)Ensemblpanpan1.1panPan2
SPTLC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,291,797 - 50,401,202 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,271,010 - 50,401,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,979,477 - 50,088,850 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,525,698 - 50,635,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,530,838 - 50,635,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1850,188,135 - 50,297,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0850,211,301 - 50,320,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,609,185 - 50,719,362 (-)NCBIUU_Cfam_GSD_1.0
SPTLC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,544,478 - 100,638,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,545,360 - 100,638,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,672,604 - 106,730,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPTLC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,769,072 - 54,876,963 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605342,955,305 - 43,064,586 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sptlc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473424,281,482 - 24,400,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003219   ⟹   ENSSTOP00000002873
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364886,289,833 - 6,296,849 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000003241   ⟹   ENSSTOP00000002894
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364886,315,715 - 6,419,882 (-)Ensembl
RefSeq Acc Id: XM_040274332   ⟹   XP_040130266
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864025,664,744 - 25,778,794 (+)NCBI
RefSeq Acc Id: XM_040274333   ⟹   XP_040130267
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864025,664,745 - 25,778,794 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040130266 (Get FASTA)   NCBI Sequence Viewer  
  XP_040130267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002873.2
  ENSSTOP00000002894.3
GenBank Protein KAG3260611 (Get FASTA)   NCBI Sequence Viewer  
  KAG3260613 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040130266   ⟸   XM_040274332
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040130267   ⟸   XM_040274333
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000002894   ⟸   ENSSTOT00000003241
Ensembl Acc Id: ENSSTOP00000002873   ⟸   ENSSTOT00000003219
Protein Domains
Aminotransferase class I/classII large   AMOP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003218 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00000003237 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003219.3 UniProtKB/TrEMBL
  ENSSTOT00000003241.3 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_II_pyridoxalP_BS UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/TrEMBL
  AMOP_dom UniProtKB/TrEMBL
  Angio_Inhib/Adhesion_GPCR UniProtKB/TrEMBL
  AON_synthase_class-II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene Sptlc2 ENTREZGENE
PANTHER CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE UniProtKB/TrEMBL
  ISTHMIN-2 UniProtKB/TrEMBL
  PTHR10239:SF28 UniProtKB/TrEMBL
  SERINE PALMITOYLTRANSFERASE 2 UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
  AMOP UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_2 UniProtKB/TrEMBL
  AMOP UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART AMOP UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt I3M1V8_ICTTR UniProtKB/TrEMBL
  I3M1X2_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101967158  serine palmitoyltransferase 2  Sptlc2  serine palmitoyltransferase long chain base subunit 2  Symbol and/or name change 5135510 APPROVED
2021-03-25 Sptlc2  serine palmitoyltransferase long chain base subunit 2  Ism2  isthmin 2  Data merged from RGD:12581583 737654 PROVISIONAL