Ercc8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit) - Rat Genome Database

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Gene: Ercc8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit) Ictidomys tridecemlineatus
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Symbol: Ercc8
Name: ERCC excision repair 8, CSA ubiquitin ligase complex subunit
RGD ID: 12727813
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of DNA repair (ortholog); response to auditory stimulus (ortholog); response to organic cyclic compound (ortholog); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH Cockayne syndrome (ortholog); Cockayne syndrome A (ortholog); genetic disease (ortholog); FOUND IN perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA excision repair protein ERCC-8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit, transcript variant X1; ERCC excision repair 8, CSA ubiquitin ligase complex subunit, transcript variant X2; ERCC excision repair 8, CSA ubiquitin ligase complex subunit, transcript variant X3; ERCC excision repair 8, CSA ubiquitin ligase complex subunit, transcript variant X4; excision repair cross-complementing rodent repair deficiency, complementation group 8
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213198,623,580 - 198,673,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364807,560,023 - 7,609,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364807,560,055 - 7,609,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ercc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213198,623,580 - 198,673,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364807,560,023 - 7,609,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364807,560,055 - 7,609,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38560,866,454 - 60,945,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl560,866,454 - 60,945,073 (-)EnsemblGRCh38hg38GRCh38
GRCh37560,162,281 - 60,240,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36560,205,415 - 60,276,648 (-)NCBINCBI36Build 36hg18NCBI36
Celera557,110,728 - 57,181,969 (-)NCBICelera
Cytogenetic Map5q12.1NCBI
HuRef557,127,788 - 57,199,016 (-)NCBIHuRef
CHM1_1560,169,330 - 60,240,587 (-)NCBICHM1_1
T2T-CHM13v2.0561,682,823 - 61,761,461 (-)NCBIT2T-CHM13v2.0
Ercc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913108,295,246 - 108,337,738 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13108,295,265 - 108,331,898 (+)EnsemblGRCm39 Ensembl
GRCm3813108,158,711 - 108,201,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13108,158,731 - 108,195,364 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713108,948,932 - 108,985,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613109,279,483 - 109,315,258 (+)NCBIMGSCv36mm8
Celera13112,496,203 - 112,532,195 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1359.69NCBI
Ercc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8241,380,901 - 41,418,294 (+)NCBIGRCr8
mRatBN7.2239,647,393 - 39,686,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl239,647,452 - 39,684,859 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx246,752,569 - 46,789,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0244,811,247 - 44,848,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0239,661,198 - 39,698,289 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0239,434,617 - 39,473,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl239,434,634 - 39,472,017 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0258,518,950 - 58,557,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4239,382,976 - 39,420,764 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1239,303,350 - 39,340,773 (+)NCBI
Celera235,489,177 - 35,526,315 (+)NCBICelera
Cytogenetic Map2q14NCBI
ERCC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2452,964,264 - 53,035,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1551,117,908 - 51,195,762 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0553,053,712 - 53,131,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1554,693,987 - 54,765,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl554,693,987 - 54,765,496 (+)Ensemblpanpan1.1panPan2
ERCC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1247,502,777 - 47,559,012 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl247,503,762 - 47,558,889 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha244,578,590 - 44,634,857 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0247,979,925 - 48,036,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl247,978,983 - 48,036,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,050,076 - 45,106,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,836,609 - 45,892,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0246,688,601 - 46,744,871 (-)NCBIUU_Cfam_GSD_1.0
ERCC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1639,701,702 - 39,770,315 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11639,704,602 - 39,770,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21642,614,301 - 42,680,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERCC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1457,048,262 - 57,128,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl457,045,018 - 57,128,307 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660495,536,897 - 5,617,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248159,054,651 - 9,134,286 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248159,054,576 - 9,135,136 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000005313   ⟹   ENSSTOP00000004762
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364807,560,023 - 7,609,648 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000035775   ⟹   ENSSTOP00000029498
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364807,560,125 - 7,588,165 (+)Ensembl
RefSeq Acc Id: XM_005319593   ⟹   XP_005319650
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,623,580 - 198,673,180 (+)NCBI
SpeTri2.0NW_0049364807,560,055 - 7,609,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021722506   ⟹   XP_021578181
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,623,592 - 198,673,180 (+)NCBI
SpeTri2.0NW_0049364807,560,075 - 7,609,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040272090   ⟹   XP_040128024
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,623,580 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272091   ⟹   XP_040128025
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,632,081 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272092   ⟹   XP_040128026
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,623,706 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272093   ⟹   XP_040128027
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,632,081 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272094   ⟹   XP_040128028
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,623,706 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272095   ⟹   XP_040128029
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,632,081 - 198,673,180 (+)NCBI
RefSeq Acc Id: XM_040272096   ⟹   XP_040128030
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213198,632,081 - 198,673,180 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005319650   ⟸   XM_005319593
- Peptide Label: isoform X1
- UniProtKB: I3M5V3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578181   ⟸   XM_021722506
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_040128024   ⟸   XM_040272090
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040128026   ⟸   XM_040272092
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040128028   ⟸   XM_040272094
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040128025   ⟸   XM_040272091
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040128027   ⟸   XM_040272093
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040128029   ⟸   XM_040272095
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040128030   ⟸   XM_040272096
- Peptide Label: isoform X5
RefSeq Acc Id: ENSSTOP00000029498   ⟸   ENSSTOT00000035775
RefSeq Acc Id: ENSSTOP00000004762   ⟸   ENSSTOT00000005313


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005308 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005313.3 UniProtKB/TrEMBL
  ENSSTOT00000035775.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  Rad28/ERCC8/Ckn1/ATCSA-1 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Ercc8 ENTREZGENE
PANTHER DNA EXCISION REPAIR PROTEIN ERCC-8 UniProtKB/TrEMBL
  PTHR46202 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A287D7J1_ICTTR UniProtKB/TrEMBL
  I3M5V3 ENTREZGENE, UniProtKB/TrEMBL