Rad50 (RAD50 double strand break repair protein) - Rat Genome Database

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Gene: Rad50 (RAD50 double strand break repair protein) Ictidomys tridecemlineatus
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Symbol: Rad50
Name: RAD50 double strand break repair protein
RGD ID: 12726738
Description: ENCODES a protein that exhibits 3'-5' exonuclease activity (ortholog); DNA helicase activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN chromosome organization (ortholog); chromosome organization involved in meiotic cell cycle (ortholog); DNA damage response (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH asthma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN chromatin (ortholog); condensed nuclear chromosome (ortholog); inclusion body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA repair protein RAD50; RAD50 double strand break repair protein, transcript variant X1; RAD50 double strand break repair protein, transcript variant X2; RAD50 double strand break repair protein, transcript variant X3; RAD50 double strand break repair protein, transcript variant X4; RAD50 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,536,406 - 115,761,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,543,599 - 2,637,846 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,546,100 - 2,637,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rad50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,536,406 - 115,761,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,543,599 - 2,637,846 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,546,100 - 2,637,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,556,977 - 132,646,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,556,019 - 132,646,349 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,892,669 - 131,982,041 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,920,529 - 132,007,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,920,528 - 132,007,492NCBI
Celera5128,022,732 - 128,110,444 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,084,875 - 127,172,627 (+)NCBIHuRef
CHM1_15131,325,888 - 131,413,608 (+)NCBICHM1_1
T2T-CHM13v2.05133,076,780 - 133,166,151 (+)NCBIT2T-CHM13v2.0
Rad50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,540,346 - 53,598,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,540,346 - 53,598,146 (-)EnsemblGRCm39 Ensembl
GRCm381153,649,519 - 53,707,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,649,519 - 53,707,319 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,463,021 - 53,520,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,492,993 - 53,550,720 (-)NCBIMGSCv36mm8
Celera1158,229,063 - 58,286,859 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
Rad50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,310,147 - 38,362,100 (-)NCBIGRCr8
mRatBN7.21037,809,353 - 37,861,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,808,726 - 37,861,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,501,288 - 42,553,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,991,358 - 42,043,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,495,080 - 37,547,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,002,130 - 39,054,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,001,498 - 39,054,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,783,860 - 38,835,810 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,112,733 - 39,164,694 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,121,979 - 39,173,935 (-)NCBI
Celera1037,153,558 - 37,205,520 (-)NCBICelera
Cytogenetic Map10q22NCBI
Rad50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,953,800 - 4,035,494 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,953,801 - 4,035,494 (+)NCBIChiLan1.0ChiLan1.0
RAD50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,867,909 - 127,955,144 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,007,455 - 126,094,708 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,972,630 - 128,059,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,134,506 - 134,222,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,134,495 - 134,222,261 (+)Ensemblpanpan1.1panPan2
RAD50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,836,863 - 20,928,930 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,836,879 - 20,928,819 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,500,587 - 19,730,384 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,484,565 - 21,714,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,622,834 - 21,714,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,203,382 - 20,433,320 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,051,430 - 20,280,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,693,292 - 20,923,363 (+)NCBIUU_Cfam_GSD_1.0
RAD50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,700,817 - 134,939,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,844,460 - 134,939,188 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,313,725 - 140,407,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAD50
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,375,206 - 35,458,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,375,305 - 35,458,622 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,481,288 - 42,568,716 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,447,461 - 39,544,409 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,445,083 - 39,544,415 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000009891   ⟹   ENSSTOP00000008870
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366472,543,599 - 2,637,846 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000029532   ⟹   ENSSTOP00000023325
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366472,608,728 - 2,637,195 (-)Ensembl
RefSeq Acc Id: XM_005335775   ⟹   XP_005335832
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,543,338 - 115,634,758 (-)NCBI
SpeTri2.0NW_0049366472,546,100 - 2,637,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733589   ⟹   XP_021589264
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,408 - 115,625,778 (-)NCBI
SpeTri2.0NW_0049366472,546,100 - 2,628,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733590   ⟹   XP_021589265
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,409 - 115,634,769 (-)NCBI
SpeTri2.0NW_0049366472,546,100 - 2,637,520 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272783   ⟹   XP_040128717
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,406 - 115,750,050 (-)NCBI
RefSeq Acc Id: XM_040272785   ⟹   XP_040128719
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,543,338 - 115,761,319 (-)NCBI
RefSeq Acc Id: XM_040272786   ⟹   XP_040128720
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,409 - 115,634,759 (-)NCBI
RefSeq Acc Id: XM_040272787   ⟹   XP_040128721
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,407 - 115,634,759 (-)NCBI
RefSeq Acc Id: XM_040272788   ⟹   XP_040128722
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,536,408 - 115,642,688 (-)NCBI
RefSeq Acc Id: XP_005335832   ⟸   XM_005335775
- Peptide Label: isoform X4
- UniProtKB: I3MEF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589265   ⟸   XM_021733590
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_021589264   ⟸   XM_021733589
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_040128717   ⟸   XM_040272783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040128721   ⟸   XM_040272787
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040128722   ⟸   XM_040272788
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040128720   ⟸   XM_040272786
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040128719   ⟸   XM_040272785
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000008870   ⟸   ENSSTOT00000009891
Ensembl Acc Id: ENSSTOP00000023325   ⟸   ENSSTOT00000029532
Protein Domains
Zinc-hook


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009876 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009891.3 UniProtKB/TrEMBL
  ENSSTOT00000029532.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Rad50/SbcC_AAA UniProtKB/TrEMBL
  Rad50_eukaryotes UniProtKB/TrEMBL
  Zn_hook_RAD50 UniProtKB/TrEMBL
NCBI Gene Rad50 ENTREZGENE
PANTHER DNA REPAIR PROTEIN RAD50 UniProtKB/TrEMBL
  RAD50 UniProtKB/TrEMBL
Pfam AAA_23 UniProtKB/TrEMBL
  Rad50_zn_hook UniProtKB/TrEMBL
  SbcC_Walker_B UniProtKB/TrEMBL
PROSITE ZN_HOOK UniProtKB/TrEMBL
Superfamily-SCOP Rad50 coiled-coil Zn hook UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt I3MEF5 ENTREZGENE, UniProtKB/TrEMBL
  I3NG28_ICTTR UniProtKB/TrEMBL