Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12)

Gene: Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12) Ictidomys tridecemlineatus

Analyze

Symbol:

Hsd17b12

Name:

hydroxysteroid 17-beta dehydrogenase 12

RGD ID:

12722381

Description:

ENCODES a protein that exhibits collagen binding (inferred); fibronectin binding (inferred); heparin binding (inferred); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); extracellular matrix (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

very-long-chain 3-oxoacyl-CoA reductase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	22,688,930 - 22,837,837 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	4,802,282 - 4,949,468 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	4,802,282 - 4,949,500 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

extracellular matrix organization (IEA,ISO)

fatty acid elongation, saturated fatty acid (IEA)

positive regulation of cell-substrate adhesion (IEA,ISO)

steroid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

extracellular matrix (IEA)

fatty acid elongase complex (IEA)

membrane (IEA)

Molecular Function

collagen binding (IEA)

fibronectin binding (IEA)

heparin binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

very-long-chain 3-oxoacyl-CoA reductase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hsd17b12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	22,688,930 - 22,837,837 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	4,802,282 - 4,949,468 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	4,802,282 - 4,949,500 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	43,556,721 - 43,856,615 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	43,680,680 - 43,856,617 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	43,702,288 - 43,878,165 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	43,658,719 - 43,834,745 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	43,658,880 - 43,834,744	NCBI
Celera	11	43,848,404 - 44,024,379 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	43,412,072 - 43,587,812 (+)	NCBI		HuRef
CHM1_1	11	43,701,792 - 43,877,827 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	43,731,842 - 44,012,332 (+)	NCBI		T2T-CHM13v2.0

Hsd17b12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	93,863,042 - 93,988,254 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	93,863,034 - 93,988,309 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	94,032,697 - 94,157,909 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	94,032,689 - 94,157,964 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	93,872,854 - 93,998,066 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	93,833,536 - 93,958,748 (-)	NCBI		MGSCv36	mm8
Celera	2	95,429,240 - 95,554,423 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	51.62	NCBI

Hsd17b12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	100,445,393 - 100,568,898 (-)	NCBI		GRCr8
mRatBN7.2	3	79,990,048 - 80,113,556 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	79,990,056 - 80,113,617 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	83,463,561 - 83,587,647 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	92,062,651 - 92,186,743 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	89,908,167 - 90,032,005 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	82,924,699 - 83,048,465 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	82,924,687 - 83,048,435 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	89,626,176 - 89,749,541 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	78,436,634 - 78,559,707 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	78,333,061 - 78,456,135 (-)	NCBI
Celera	3	79,190,922 - 79,314,232 (-)	NCBI		Celera
Cytogenetic Map	3	q31	NCBI

Hsd17b12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	3,717,666 - 3,864,801 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	3,721,452 - 3,864,801 (-)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	45,895,986 - 46,071,909 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	45,901,905 - 46,077,829 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	43,641,323 - 43,817,214 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	44,137,597 - 44,312,986 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	44,137,597 - 44,312,986 (+)	Ensembl	panpan1.1		panPan2

HSD17B12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,907,366 - 26,061,643 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,908,555 - 26,061,616 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,594,145 - 25,748,413 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	26,529,683 - 26,683,219 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	26,529,049 - 26,683,212 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	26,039,150 - 26,192,361 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,684,733 - 25,839,066 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	26,296,764 - 26,451,042 (-)	NCBI		UU_Cfam_GSD_1.0

HSD17B12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	18,456,019 - 18,611,782 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	18,461,487 - 18,611,761 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	20,061,561 - 20,211,999 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	21,530,292 - 21,702,552 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	21,528,391 - 21,702,455 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	118,767,304 - 118,938,354 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	4,160,053 - 4,316,370 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	4,163,452 - 4,315,827 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005330041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005471 ⟹ ENSSTOP00000004895

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936562	4,802,282 - 4,949,468 (-)	Ensembl

RefSeq Acc Id:

XM_005330041 ⟹ XP_005330098

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	22,688,930 - 22,837,837 (-)	NCBI
SpeTri2.0	NW_004936562	4,802,282 - 4,949,500 (-)	NCBI

Sequence:

show sequence

ATATGGCGCCGTGGGCGGGGTTTAGGCTCAAAGGGTTCTACGAAAGGCGCGTGAGTGTCGTCCT
CGCAGTCACAGCTGGCACCTCCTTCTGACTTCATTCATTCGGTTTTTTTTTTTCTTCCATTCAC
GGAGGTAGAAAGGCCTGCTCGAAAGCCATGGAGAGCGCTCTCCCTGCTGCCAGCTTCCTGTACT
GGGTAGGCTTTGGCACCGTGGCCTACCTGTCCCTCCGCATCTCGTACTCGCTCTACTCGGCTCT
TCGCGTCTGGGGTGTGGGTAACGAGGCGGGGGTCGGCCCGGCGCTCGGTGAATGGGCAGTTGTC
ACAGGTAGTACTGATGGAATTGGAAAAGCATATGCAGAAGAGCTAGCAAATCATGGAATGAAGG
TTGTCCTAATCAGCCGATCACAAGACAAACTGAACCAGGTTTCCAGTGAGATAAAAGAAAAATT
CAAAGTGGAGACAAGGACCATTGCTGTTGACTTTACATCAGAAGATATTTATGATAAAATTAAA
ACAGACCTGGCGGGTCTTGAAATTGGCATTTTAGTGAACAATGTGGGAATCTCATATGAGTATC
CTGAATACTTTTTGGAAATTCCTGACTTGGACAATGCCATTAAGAAACTGATAAATGTTAATAT
TCTTTCTGTTTGTAAGATGACACGAGTGGTGCTGCCTGGCATGGTAGAAAGGTCTAAAGGTGCA
ATTCTGAACATCTCCTCTGCCAGTGGCGTGTTTCCGGTTCCACTATTGGCCATCTACTCTGCGA
CCAAGGCTTTTGTAGATTTCTTCTCTCAGTGCCTCCATGAGGAGTATAGAAGCAAGGGCATCTT
TGTGCAGAGTGTCCTGCCATTCTACGTAGCTACAAAACTGGCTAAAATCCGAAAGCCAACTTGG
GACAAGCCCTCTTCAGAGACATTTGTGAAATCTGCAGTTAAAACAGTAGGCTTGCAGTCCCGAA
CCAATGGATACCTGATCCATTCTCTTATGGGCTCAATAATCTCCATCCTGCCTTCTTGGATTTA
CCTTAAAATATCCATGGGTCTCAACAAGTCTGTGAGGGCTCGCTATCTGAAGAAAGCCAAGAAG
AACTAAACGGCATCCCACAGCCAGATGCTTCTGCCTGTGCACGTTCGCTGCAGGGCACCCACCA
GTCCCCAGAAGCTGCTGTTCTCATTGCAGCAATTGCTAACCTGGCCAAATGTTGTCATGATTTG
GAGGAAAAAAGAAGTTGCTTTTAGAAGTTCCCGACACATGTTCTGGATTCCACCAGAACTAATT
TTGAAGTTTAATATAAACACTCATATAAAATGGATGTAGAACTCATATTACCAAGAACAATTTA
ATAGGAAAAAACATGATTATAGCAAATCACAGAATGACAAACATAAAAGCCATCTGTTCCATCT
GGCCCCAAAGTCAGTGATCATTATTATATTTTCTCTAAAAACATACCATAAAATACAATCACTA
GCAATTCTTTTTTTCTTTTTTTTTTTAAATTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005330098	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004895.3
GenBank Protein	KAG3285441	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005330098 ⟸ XM_005330041

- UniProtKB:

I3M648 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESALPAASFLYWVGFGTVAYLSLRISYSLYSALRVWGVGNEAGVGPALGEWAVVTGSTDGIGK
AYAEELANHGMKVVLISRSQDKLNQVSSEIKEKFKVETRTIAVDFTSEDIYDKIKTDLAGLEIG
ILVNNVGISYEYPEYFLEIPDLDNAIKKLINVNILSVCKMTRVVLPGMVERSKGAILNISSASG
VFPVPLLAIYSATKAFVDFFSQCLHEEYRSKGIFVQSVLPFYVATKLAKIRKPTWDKPSSETFV
KSAVKTVGLQSRTNGYLIHSLMGSIISILPSWIYLKISMGLNKSVRARYLKKAKKN

hide sequence

RefSeq Acc Id:

ENSSTOP00000004895 ⟸ ENSSTOT00000005471

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005473	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005471.3	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Hsd17b12	ENTREZGENE
PANTHER	RH59310P	UniProtKB/TrEMBL
	VERY-LONG-CHAIN 3-OXOACYL-COA REDUCTASE	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PIRSF	11-beta-HSD1	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	I3M648	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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