Wrn (WRN RecQ like helicase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Wrn (WRN RecQ like helicase) Ictidomys tridecemlineatus
Analyze
Symbol: Wrn
Name: WRN RecQ like helicase
RGD ID: 12721742
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to starvation (ortholog); determination of adult lifespan (ortholog); DNA metabolic process (ortholog); ASSOCIATED WITH breast cancer (ortholog); coronary artery disease (ortholog); diffuse scleroderma (ortholog); FOUND IN nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Werner syndrome ATP-dependent helicase; Werner syndrome RecQ like helicase; Werner syndrome RecQ like helicase, transcript variant X1; Werner syndrome RecQ like helicase, transcript variant X2; Werner syndrome RecQ like helicase, transcript variant X3; Werner syndrome RecQ like helicase, transcript variant X4; Werner syndrome RecQ like helicase, transcript variant X5; Werner syndrome RecQ like helicase, transcript variant X6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,358,222 - 56,501,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,358,222 - 56,501,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,033,810 - 31,176,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl831,033,788 - 31,176,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37830,891,326 - 31,033,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,010,320 - 31,150,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 34831,010,319 - 31,150,818NCBI
Celera829,850,819 - 29,989,925 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,435,610 - 29,576,278 (+)NCBIHuRef
CHM1_1831,092,222 - 31,232,737 (+)NCBICHM1_1
T2T-CHM13v2.0831,314,935 - 31,457,266 (+)NCBIT2T-CHM13v2.0
Wrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39833,724,400 - 33,875,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl833,724,412 - 33,875,555 (-)EnsemblGRCm39 Ensembl
GRCm38833,234,372 - 33,385,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,344,845 - 34,495,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36834,700,308 - 34,851,437 (-)NCBIMGSCv36mm8
Celera835,829,900 - 36,023,160 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.3NCBI
Wrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,466,552 - 65,602,951 (+)NCBIGRCr8
mRatBN7.21658,763,517 - 58,898,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
Wrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBIChiLan1.0ChiLan1.0
WRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,612,933 - 49,764,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,329,155 - 25,486,021 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,353,643 - 30,492,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,541,145 - 27,679,855 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,541,145 - 27,679,855 (+)Ensemblpanpan1.1panPan2
WRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,164,662 - 33,304,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,167,364 - 33,304,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,688,179 - 33,763,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,190,440 - 35,330,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,190,442 - 35,331,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,288,917 - 33,429,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01633,863,786 - 34,003,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01633,981,929 - 34,122,272 (-)NCBIUU_Cfam_GSD_1.0
WRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1553,966,986 - 54,094,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11553,966,968 - 54,094,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,329,196 - 61,464,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,150,256 - 29,288,830 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl829,174,229 - 29,289,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605212,803,116 - 12,942,546 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478012,876,093 - 13,025,739 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478012,875,747 - 13,051,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013614   ⟹   ENSSTOP00000012199
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)Ensembl
RefSeq Acc Id: XM_013365229   ⟹   XP_013220683
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,114 (-)NCBI
SpeTri2.0NW_004936792862,660 - 1,005,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720263   ⟹   XP_021575938
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,118 (-)NCBI
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720264   ⟹   XP_021575939
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,118 (-)NCBI
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720265   ⟹   XP_021575940
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,118 (-)NCBI
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720266   ⟹   XP_021575941
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,120 (-)NCBI
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040269109   ⟹   XP_040125043
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,119 (-)NCBI
RefSeq Acc Id: XM_040269111   ⟹   XP_040125045
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,119 (-)NCBI
RefSeq Acc Id: XM_040269120   ⟹   XP_040125054
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,475,128 (-)NCBI
RefSeq Acc Id: XM_040269122   ⟹   XP_040125056
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,501,120 (-)NCBI
RefSeq Acc Id: XM_040269127   ⟹   XP_040125061
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,358,222 - 56,469,400 (-)NCBI
RefSeq Acc Id: XR_005726416
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494356,360,289 - 56,501,123 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013220683   ⟸   XM_013365229
- Peptide Label: isoform X3
- UniProtKB: I3MLC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021575938   ⟸   XM_021720263
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021575939   ⟸   XM_021720264
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021575940   ⟸   XM_021720265
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021575941   ⟸   XM_021720266
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_040125056   ⟸   XM_040269122
- Peptide Label: isoform X9
RefSeq Acc Id: XP_040125045   ⟸   XM_040269111
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040125043   ⟸   XM_040269109
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040125054   ⟸   XM_040269120
- Peptide Label: isoform X8
RefSeq Acc Id: XP_040125061   ⟸   XM_040269127
- Peptide Label: isoform X10
RefSeq Acc Id: ENSSTOP00000012199   ⟸   ENSSTOT00000013614
Protein Domains
Helicase ATP-binding   Helicase C-terminal   HRDC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013599 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013614.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.80 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 3'-5'_exonuclease_dom UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  Helicase_HTH UniProtKB/TrEMBL
  HRDC-like_sf UniProtKB/TrEMBL
  HRDC_dom UniProtKB/TrEMBL
  HRDC_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecQ_Zn-bd UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  RQC_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Wrn ENTREZGENE
PANTHER DNA HELICASE RECQ FAMILY MEMBER UniProtKB/TrEMBL
  WERNER SYNDROME ATP-DEPENDENT HELICASE UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  DNA_pol_A_exo1 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  HTH_40 UniProtKB/TrEMBL
  RecQ_Zn_bind UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
SMART 35EXOc UniProtKB/TrEMBL
  DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF47819 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
UniProt I3MLC3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-23 Wrn  WRN RecQ like helicase    Werner syndrome RecQ like helicase  Symbol and/or name change 5135510 APPROVED