Leo1 (LEO1 homolog, Paf1/RNA polymerase II complex component) - Rat Genome Database

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Gene: Leo1 (LEO1 homolog, Paf1/RNA polymerase II complex component) Ictidomys tridecemlineatus
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Symbol: Leo1
Name: LEO1 homolog, Paf1/RNA polymerase II complex component
RGD ID: 12720314
Description: INVOLVED IN endodermal cell fate commitment (ortholog); histone H2B ubiquitination (ortholog); histone monoubiquitination (ortholog); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); FOUND IN Cdc73/Paf1 complex (ortholog); centrosome (ortholog); fibrillar center (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Leo1, Paf1/RNA polymerase II complex component, homolog; LOC101959183; RNA polymerase-associated protein LEO1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864095,904,998 - 95,935,951 (-)NCBI
SpeTri2.0NW_00493647113,753,061 - 13,783,990 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Leo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864095,904,998 - 95,935,951 (-)NCBI
SpeTri2.0NW_00493647113,753,061 - 13,783,990 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1551,938,025 - 51,971,778 (-)EnsemblGRCh38hg38GRCh38
GRCh381551,938,024 - 51,971,798 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371552,230,222 - 52,263,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,017,514 - 50,051,250 (-)NCBINCBI36hg18NCBI36
Celera1529,123,636 - 29,157,376 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1529,060,926 - 29,094,625 (-)NCBIHuRef
CHM1_11552,348,273 - 52,382,049 (-)NCBICHM1_1
Leo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39975,348,072 - 75,373,714 (+)NCBIGRCm39mm39
GRCm39 Ensembl975,348,806 - 75,373,714 (+)Ensembl
GRCm38975,441,015 - 75,466,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,441,524 - 75,466,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37975,289,331 - 75,314,239 (+)NCBIGRCm37mm9NCBIm37
MGSCv36975,227,433 - 75,252,341 (+)NCBImm8
Celera972,601,044 - 72,627,947 (+)NCBICelera
Cytogenetic Map9DNCBI
Leo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2876,199,547 - 76,223,983 (+)NCBI
Rnor_6.0 Ensembl882,380,757 - 82,405,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0882,380,906 - 82,405,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0881,983,993 - 82,008,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,266,160 - 80,290,547 (+)NCBIRGSC3.4rn4RGSC3.4
Celera875,989,197 - 76,013,584 (+)NCBICelera
Cytogenetic Map8q24NCBI
Leo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,711,564 - 2,727,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554092,711,475 - 2,727,879 (+)NCBIChiLan1.0ChiLan1.0
LEO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13017,614,502 - 17,651,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3017,598,076 - 17,651,290 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3017,541,113 - 17,578,528 (-)NCBI
ROS_Cfam_1.03017,760,917 - 17,798,265 (-)NCBI
UMICH_Zoey_3.13017,682,358 - 17,719,762 (-)NCBI
UNSW_CanFamBas_1.03017,800,296 - 17,837,557 (-)NCBI
UU_Cfam_GSD_1.03017,906,850 - 17,943,999 (-)NCBI
LEO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,805,039 - 119,897,073 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,804,992 - 119,842,343 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,895,440 - 132,932,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEO1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12631,405,019 - 31,444,350 (+)NCBI
ChlSab1.1 Ensembl2631,404,537 - 31,445,198 (+)Ensembl
Leo1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247318,467,914 - 8,485,978 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005316581   ⟹   XP_005316638
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864095,904,998 - 95,935,951 (-)NCBI
SpeTri2.0NW_00493647113,753,061 - 13,783,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021726783   ⟹   XP_021582458
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864095,905,168 - 95,935,951 (-)NCBI
SpeTri2.0NW_00493647113,753,231 - 13,783,990 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005316638 (Get FASTA)   NCBI Sequence Viewer  
  XP_021582458 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005316638   ⟸   XM_005316581
- Peptide Label: isoform X1
- UniProtKB: I3ND02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021582458   ⟸   XM_021726783
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020671 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000022249 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021214 UniProtKB/TrEMBL
InterPro Leo1 UniProtKB/TrEMBL
NCBI Gene Leo1 ENTREZGENE
PANTHER PTHR23146 UniProtKB/TrEMBL
Pfam Leo1 UniProtKB/TrEMBL
UniProt I3ND02 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Leo1  LEO1 homolog, Paf1/RNA polymerase II complex component  LOC101959183  RNA polymerase-associated protein LEO1  Symbol and/or name change 5135510 APPROVED
2017-07-13 LOC101959183  RNA polymerase-associated protein LEO1  Leo1  LEO1 homolog, Paf1/RNA polymerase II complex component  Symbol and/or name change 5135510 APPROVED