Tmem126a (transmembrane protein 126A)

Gene: Tmem126a (transmembrane protein 126A) Ictidomys tridecemlineatus

Analyze

Symbol:

Tmem126a

Name:

transmembrane protein 126A

RGD ID:

12719802

Description:

INVOLVED IN mitochondrial protein quality control (ortholog); optic nerve development (ortholog); protein insertion into mitochondrial inner membrane from matrix (ortholog); ASSOCIATED WITH exudative vitreoretinopathy 1 (ortholog); genetic disease (ortholog); Hereditary Optic Atrophies (ortholog); FOUND IN mitochondrial inner membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	71,938,905 - 71,945,739 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936498	13,538,565 - 13,545,338 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

exudative vitreoretinopathy 1 (ISO)

genetic disease (ISO)

Hereditary Optic Atrophies (ISO)

intellectual disability (ISO)

optic atrophy 7 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial protein quality control (ISO)

mitochondrial respiratory chain complex I assembly (IEA)

optic nerve development (ISO)

protein insertion into mitochondrial inner membrane from matrix (ISO)

toll-like receptor 4 signaling pathway (ISO)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (ISO)

mitochondrion (IEA)

plasma membrane (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Tmem126a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	71,938,905 - 71,945,739 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936498	13,538,565 - 13,545,338 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM126A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	85,647,967 - 85,656,542 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	85,647,967 - 85,656,547 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	85,359,011 - 85,367,586 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	85,036,693 - 85,045,235 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	82,668,277 - 82,676,912 (+)	NCBI		Celera
Cytogenetic Map	11	q14.1	NCBI
HuRef	11	81,656,256 - 81,664,891 (+)	NCBI		HuRef
CHM1_1	11	85,243,754 - 85,252,388 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	85,584,644 - 85,593,220 (+)	NCBI		T2T-CHM13v2.0

Tmem126a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	90,099,908 - 90,106,411 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	90,099,908 - 90,106,437 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	90,450,700 - 90,457,203 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	90,450,700 - 90,457,229 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	97,599,222 - 97,605,718 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	90,325,904 - 90,332,400 (-)	NCBI		MGSCv36	mm8
Celera	7	87,778,196 - 87,784,676 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI
cM Map	7	50.59	NCBI

Tmem126a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	153,837,015 - 153,843,192 (-)	NCBI		GRCr8
mRatBN7.2	1	144,424,481 - 144,430,730 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	144,422,703 - 144,430,628 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	152,347,274 - 152,353,446 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	159,528,451 - 159,534,610 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	152,402,370 - 152,408,529 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	156,283,105 - 156,291,057 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	156,283,128 - 156,291,052 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	162,529,113 - 162,537,179 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	147,129,330 - 147,137,259 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	147,207,735 - 147,215,665 (-)	NCBI
Celera	1	142,643,098 - 142,651,027 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Tmem126a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	7,216,286 - 7,224,475 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	7,214,408 - 7,224,499 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM126A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	86,567,317 - 86,579,574 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	87,620,767 - 87,630,548 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	80,703,855 - 80,712,459 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	84,312,434 - 84,321,037 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	84,312,434 - 84,321,037 (+)	Ensembl	panpan1.1		panPan2

TMEM126A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	13,787,074 - 13,795,779 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	13,787,123 - 13,795,739 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	13,653,725 - 13,662,471 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	13,967,872 - 13,976,597 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	13,967,464 - 13,976,562 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	13,756,370 - 13,765,102 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	13,828,697 - 13,837,423 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	13,881,469 - 13,890,217 (-)	NCBI		UU_Cfam_GSD_1.0

TMEM126A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	19,576,295 - 19,585,277 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	19,576,241 - 19,585,869 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	21,846,389 - 21,855,417 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM126A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	76,888,688 - 76,897,883 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	76,888,734 - 76,897,841 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	48,824,623 - 48,833,726 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem126a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624845	4,264,497 - 4,272,973 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005323272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005323271 ⟹ XP_005323328

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	71,938,971 - 71,945,739 (+)	NCBI
SpeTri2.0	NW_004936498	13,538,593 - 13,545,338 (+)	NCBI

Sequence:

show sequence

GTGTCTGCCGAAGATGGCTGCGCTGGGAGGAACGGAGTAAAGGTTGTATCTTAAGCCCCGGCGT
GTTAGAACAGGGGAGGCACCGGCTGTTGGGAGGAGAGCAGCAGGGTCAAGATGGAAAATCATAA
ACCACATGATACTATCAAGGAAAAGTCAATTTTTGATATCATAGCCAGAAAAATTGAACTACTA
CCAGAAGCAGAAAGGAATCTTCTTGAACATGGATCCACATATATTGGACTTAATGCTGCTCTTT
GTGGCCTAATAGCAAACAGTCTTTTTCGGCGTGTCTTGCATGTAACACAGGCCCGAATAGCTGC
TAGCTTACCAATGGCAGTGCTCCCATTTTTGACAGCAAATGCATCTTTCAAAGGTTTTGTAAGT
TTACCTTTGAGTACAGGTGATTTGAATTGTGAAACCTGTACTGTGACACGGGGTGGACTTGTTG
GTTTAGTTTTAGGAGGTCTGTATCCTGTTTTCTTGGCTATACCTATAAATGGTGGCCTAGCAGC
CAGGTATCAATCAGCCCTGCTACCAGAGAAAGGAAACACCTTAACTTACTGGATTAAAATTTCT
AAGCCTATCTTCAGAAAGATGTTATTTCCCATTTTACTTCAGACTATGTTTGCAGCATACCTTG
GGTCTAGACAATATAAAGTACTTATAAAGGCCCTTCAGTTACCTGAACCAGGCCTAGAAATTCA
CTGATTTAGAGGAAATGTGTATACAAAATAAAATTGCGAAGATAACCTGTCTCTCTTAATGTTA
AAAA

hide sequence

RefSeq Acc Id:

XM_005323272 ⟹ XP_005323329

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	71,938,905 - 71,945,739 (+)	NCBI
SpeTri2.0	NW_004936498	13,538,565 - 13,545,338 (+)	NCBI

Sequence:

show sequence

CAGGAAGCGGCTGCTACCTCCGAGTCACGTGTCTGCCGAAGATGGCTGCGCTGGGAGGAACGGA
GTAAAGGGTCAAGATGGAAAATCATAAACCACATGATACTATCAAGGAAAAGTCAATTTTTGAT
ATCATAGCCAGAAAAATTGAACTACTACCAGAAGCAGAAAGGAATCTTCTTGAACATGGATCCA
CATATATTGGACTTAATGCTGCTCTTTGTGGCCTAATAGCAAACAGTCTTTTTCGGCGTGTCTT
GCATGTAACACAGGCCCGAATAGCTGCTAGCTTACCAATGGCAGTGCTCCCATTTTTGACAGCA
AATGCATCTTTCAAAGGTTTTGTAAGTTTACCTTTGAGTACAGGTGATTTGAATTGTGAAACCT
GTACTGTGACACGGGGTGGACTTGTTGGTTTAGTTTTAGGAGGTCTGTATCCTGTTTTCTTGGC
TATACCTATAAATGGTGGCCTAGCAGCCAGGTATCAATCAGCCCTGCTACCAGAGAAAGGAAAC
ACCTTAACTTACTGGATTAAAATTTCTAAGCCTATCTTCAGAAAGATGTTATTTCCCATTTTAC
TTCAGACTATGTTTGCAGCATACCTTGGGTCTAGACAATATAAAGTACTTATAAAGGCCCTTCA
GTTACCTGAACCAGGCCTAGAAATTCACTGATTTAGAGGAAATGTGTATACAAAATAAAATTGC
GAAGATAACCTGTCTCTCTTAATGTTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323328	(Get FASTA)	NCBI Sequence Viewer
	XP_005323329	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014416.3
GenBank Protein	KAG3286272	(Get FASTA)	NCBI Sequence Viewer
	KAG3286273	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005323329 ⟸ XM_005323272
- UniProtKB:	I3MQX7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MENHKPHDTIKEKSIFDIIARKIELLPEAERNLLEHGSTYIGLNAALCGLIANSLFRRVLHVTQ ARIAASLPMAVLPFLTANASFKGFVSLPLSTGDLNCETCTVTRGGLVGLVLGGLYPVFLAIPIN GGLAARYQSALLPEKGNTLTYWIKISKPIFRKMLFPILLQTMFAAYLGSRQYKVLIKALQLPEP GLEIH hide sequence

RefSeq Acc Id:	XP_005323328 ⟸ XM_005323271
- UniProtKB:	I3MQX7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MENHKPHDTIKEKSIFDIIARKIELLPEAERNLLEHGSTYIGLNAALCGLIANSLFRRVLHVTQ ARIAASLPMAVLPFLTANASFKGFVSLPLSTGDLNCETCTVTRGGLVGLVLGGLYPVFLAIPIN GGLAARYQSALLPEKGNTLTYWIKISKPIFRKMLFPILLQTMFAAYLGSRQYKVLIKALQLPEP GLEIH hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016101	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016104.3	UniProtKB/TrEMBL
InterPro	TMEM126	UniProtKB/TrEMBL
NCBI Gene	Tmem126a	ENTREZGENE
PANTHER	PTHR16296	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 126A	UniProtKB/TrEMBL
Pfam	TMEM126	UniProtKB/TrEMBL
UniProt	I3MQX7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM