Ormdl2 (ORMDL sphingolipid biosynthesis regulator 2)

Gene: Ormdl2 (ORMDL sphingolipid biosynthesis regulator 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Ormdl2

Name:

ORMDL sphingolipid biosynthesis regulator 2

RGD ID:

12714971

Description:

INVOLVED IN negative regulation of ceramide biosynthetic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ORM1-like 2; ORM1-like protein 2; ORMDL sphingolipid biosynthesis regulator 2, transcript variant X1; ORMDL sphingolipid biosynthesis regulator 2, transcript variant X2; ORMDL sphingolipid biosynthesis regulator 2, transcript variant X3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,586,738 - 58,589,508 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	280,661 - 287,144 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	280,745 - 283,488 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular lipid metabolic process (IEA)

ceramide metabolic process (IEA)

intracellular sphingolipid homeostasis (IEA)

negative regulation of ceramide biosynthetic process (IEA,ISO)

regulation of ceramide biosynthetic process (IEA)

sphingolipid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

SPOTS complex (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ormdl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,586,738 - 58,589,508 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	280,661 - 287,144 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	280,745 - 283,488 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORMDL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,818,041 - 55,821,879 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,818,041 - 55,821,879 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,211,825 - 56,215,663 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,498,073 - 54,501,226 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	54,499,048 - 54,501,224	NCBI
Celera	12	55,864,167 - 55,867,320 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,250,189 - 53,253,342 (+)	NCBI		HuRef
CHM1_1	12	56,178,576 - 56,181,729 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,784,685 - 55,788,525 (+)	NCBI		T2T-CHM13v2.0

Ormdl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,653,771 - 128,657,498 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,653,771 - 128,657,514 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,817,902 - 128,821,629 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,817,902 - 128,821,645 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,254,513 - 128,258,687 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	128,220,851 - 128,224,543 (-)	NCBI		MGSCv36	mm8
Celera	10	131,210,016 - 131,214,206 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.16	NCBI

Ormdl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,832,368 - 1,835,501 (-)	NCBI		GRCr8
mRatBN7.2	7	1,247,869 - 1,250,999 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,246,479 - 1,250,907 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	4,012,326 - 4,015,404 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,887,987 - 5,891,065 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	6,189,261 - 6,192,341 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	3,242,991 - 3,246,085 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,242,991 - 3,246,071 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,214,561 - 3,217,649 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,118,025 - 2,121,105 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,118,029 - 2,121,070 (-)	NCBI
Celera	7	1,118,626 - 1,121,706 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Ormdl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,451,021 - 3,457,086 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,451,434 - 3,454,259 (+)	NCBI	ChiLan1.0	ChiLan1.0

ORMDL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,507,967 - 38,510,461 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,504,753 - 38,507,231 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,091,020 - 33,093,794 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,814,895 - 33,818,669 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,815,514 - 33,818,669 (-)	Ensembl	panpan1.1		panPan2

ORMDL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	203,750 - 206,247 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	259,654 - 268,284 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	204,482 - 213,096 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	210,674 - 217,396 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	182,409 - 191,038 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	425,203 - 433,856 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	549,440 - 558,070 (+)	NCBI		UU_Cfam_GSD_1.0

ORMDL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,262,193 - 21,264,685 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,262,134 - 21,264,689 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	22,742,352 - 22,744,872 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORMDL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,768,533 - 51,771,461 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,768,642 - 51,770,998 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,221,943 - 194,225,433 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ormdl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	12,197,114 - 12,199,983 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	12,197,114 - 12,200,044 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005335597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005335598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000000283 ⟹ ENSSTOP00000000252

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936646	280,661 - 287,144 (+)	Ensembl

RefSeq Acc Id:

XM_005335597 ⟹ XP_005335654

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	58,586,738 - 58,589,426 (-)	NCBI
SpeTri2.0	NW_004936646	280,853 - 283,488 (+)	NCBI

Sequence:

show sequence

TTCCTGGAGACCACAGGTATAGGAGCTAGCGCCGTGACCCTATACGGACGTGCTCCTGAAGCTG
GCAGGAGATAACTATCGGAAACAAACTCAAACAGGGGTTGAAAGGAAATTGAGTTGGACTCCCA
CCTGATCCCTCACTGTGGTAGGATGAATGTGGGGGTGGCACACAGTGAAGTAAACCCCAACACC
CGAGTCATGAATAGTCGGGGCATCTGGCTGGCCTACATCATCTTGGTAGGACTGCTGCATGTGG
TTCTACTCAGCATCCCCTTCTTCAGCATTCCTGTTGTCTGGACCCTGACCAACGTCATCCATAA
CTTGGCAATGTATATCTTCTTACACACAGTAAAAGGAACACCCTTTGAAACCCCTGACCAAGGA
AAGGCTCGGCTACTGACGCACTGGGAGCAGATGGACTATGGGCTCCAGTTTACTTCTTCTCGCA
AATTCCTTAGCATCTCTCCTATCATACTCTATCTCCTGGCCAGCTTCTACACCAAATATGATGC
TGCTCACTTCCTCATCAACACTACCTCACTGCTCAGTGTACTGCTGCCTAAGTTACCTCAATTC
CATGGGGTTCGTCTCTTTGGCATTAACAAATACTGAGGGATGGGGCTAAGAGCAGTTCCACGGG
CATGGAGAAGGTGCTGGAACAAAAGGCTGTAACATCTTCCCCTTCTCCATACTATTTTGTGTGT
CTTGAAAGTCCGAGAAGTATACAACCTCTCCCCAAACTCTCAGAAAGGGGAGATTGGGAAATGG
GGCTCCTGGGCCCAGCCCTGCTATGTGCAAGATTCTTTGAATCAGGAAAAGCAGATGGGGTTAA
GAGCCAAATCAACAGGAAGGTTTCCAAGTTTGGGCAGCTTGTTGGTGGTTACATTTTTCCATAT
CTTCCACCCCCTACCACCTTCTAGCTTCTGCTTTGTCTTTTCCTTATAATAAAGTAACTTTTTC
AGTGA

hide sequence

RefSeq Acc Id:

XM_005335598 ⟹ XP_005335655

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	58,586,738 - 58,589,508 (-)	NCBI
SpeTri2.0	NW_004936646	280,745 - 283,488 (+)	NCBI

Sequence:

show sequence

ACAGAAAGGGCGGCCAATTGTCCGTCTTCATTACAGTCTGCCAACCAATTGGTGGTGACATCGC
TGGTTCTGTTCCACCAATACGGACCCCGCAGGTGTGGAGGCTACTTCCTGGAGACCACAGGTAT
AGGAGCTAGCGCCGTGACCCTATACGGACGTGCTCCTGAAGCTGGCAGGATGAATGTGGGGGTG
GCACACAGTGAAGTAAACCCCAACACCCGAGTCATGAATAGTCGGGGCATCTGGCTGGCCTACA
TCATCTTGGTAGGACTGCTGCATGTGGTTCTACTCAGCATCCCCTTCTTCAGCATTCCTGTTGT
CTGGACCCTGACCAACGTCATCCATAACTTGGCAATGTATATCTTCTTACACACAGTAAAAGGA
ACACCCTTTGAAACCCCTGACCAAGGAAAGGCTCGGCTACTGACGCACTGGGAGCAGATGGACT
ATGGGCTCCAGTTTACTTCTTCTCGCAAATTCCTTAGCATCTCTCCTATCATACTCTATCTCCT
GGCCAGCTTCTACACCAAATATGATGCTGCTCACTTCCTCATCAACACTACCTCACTGCTCAGT
GTACTGCTGCCTAAGTTACCTCAATTCCATGGGGTTCGTCTCTTTGGCATTAACAAATACTGAG
GGATGGGGCTAAGAGCAGTTCCACGGGCATGGAGAAGGTGCTGGAACAAAAGGCTGTAACATCT
TCCCCTTCTCCATACTATTTTGTGTGTCTTGAAAGTCCGAGAAGTATACAACCTCTCCCCAAAC
TCTCAGAAAGGGGAGATTGGGAAATGGGGCTCCTGGGCCCAGCCCTGCTATGTGCAAGATTCTT
TGAATCAGGAAAAGCAGATGGGGTTAAGAGCCAAATCAACAGGAAGGTTTCCAAGTTTGGGCAG
CTTGTTGGTGGTTACATTTTTCCATATCTTCCACCCCCTACCACCTTCTAGCTTCTGCTTTGTC
TTTTCCTTATAATAAAGTAACTTTTTCAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005335654	(Get FASTA)	NCBI Sequence Viewer
	XP_005335655	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000252.2
GenBank Protein	KAG3291673	(Get FASTA)	NCBI Sequence Viewer
	KAG3291674	(Get FASTA)	NCBI Sequence Viewer
	KAG3291675	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005335654 ⟸ XM_005335597
- Peptide Label:	isoform X2
- UniProtKB:	I3LWA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYIFL HTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIILYLLASFYTKYDAAHFLINT TSLLSVLLPKLPQFHGVRLFGINKY hide sequence

RefSeq Acc Id:	XP_005335655 ⟸ XM_005335598
- Peptide Label:	isoform X1
- Sequence:	show sequence MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYIFL HTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIILYLLASFYTKYDAAHFLINT TSLLSVLLPKLPQFHGVRLFGINKY hide sequence

RefSeq Acc Id:

ENSSTOP00000000252 ⟸ ENSSTOT00000000283

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000285	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000283.3	UniProtKB/TrEMBL
InterPro	ORMDL	UniProtKB/TrEMBL
NCBI Gene	Ormdl2	ENTREZGENE
PANTHER	PTHR12665	UniProtKB/TrEMBL
	PTHR12665:SF13	UniProtKB/TrEMBL
Pfam	ORMDL	UniProtKB/TrEMBL
PIRSF	ORMDL	UniProtKB/TrEMBL
UniProt	I3LWA9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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