Glyctk (glycerate kinase) - Rat Genome Database

Name: Glyctk
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Glyctk (glycerate kinase) Ictidomys tridecemlineatus

Analyze

Symbol:

Glyctk

Name:

glycerate kinase

RGD ID:

12712687

Description:

ENCODES a protein that exhibits glycerate kinase activity (inferred); INVOLVED IN fructose catabolic process (ortholog); PARTICIPATES IN D-glycericacidemia pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH congenital disorder of glycosylation In (ortholog); D-glyceric aciduria (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glycerate kinase, transcript variant X1; glycerate kinase, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLYCTK (glycerate kinase)	NCBI	Ortholog
Mus musculus (house mouse):	Glyctk (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Glyctk (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Glyctk (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLYCTK (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLYCTK (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GLYCTK (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GLYCTK (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Glyctk (glycerate kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	66,866,696 - 66,872,727 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	3,628,822 - 3,635,236 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	3,627,194 - 3,635,568 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation In (ISO)

D-glyceric aciduria (ISO)

genetic disease (ISO)

Non Ketotic Hyperglycinemia Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fructose catabolic process (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

Golgi apparatus (IEA)

Molecular Function

glycerate kinase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

D-glycericacidemia pathway (ISO)

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

familial lipoprotein lipase deficiency pathway (ISO)

glycerol kinase deficiency pathway (ISO)

glycerolipid metabolic pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

sarcosinemia pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Glyctk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	66,866,696 - 66,872,727 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	3,628,822 - 3,635,236 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	3,627,194 - 3,635,568 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GLYCTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	52,287,828 - 52,295,257 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	52,287,089 - 52,295,257 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	52,321,844 - 52,329,273 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,296,912 - 52,302,532 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	52,301,159 - 52,308,595 (+)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	52,384,478 - 52,391,914 (+)	NCBI		HuRef
CHM1_1	3	52,274,371 - 52,281,807 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	52,320,727 - 52,349,445 (+)	NCBI		T2T-CHM13v2.0

Glyctk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	106,030,058 - 106,037,353 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	106,030,056 - 106,035,337 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	106,152,859 - 106,160,158 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	106,152,857 - 106,158,138 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	106,055,191 - 106,060,469 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	106,010,961 - 106,016,239 (-)	NCBI		MGSCv36	mm8
Celera	9	105,776,846 - 105,782,154 (-)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	57.46	NCBI

Glyctk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,676,071 - 115,681,403 (-)	NCBI		GRCr8
mRatBN7.2	8	106,795,461 - 106,802,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	106,797,343 - 106,802,397 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	112,421,933 - 112,426,948 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,621,106 - 110,626,120 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	108,463,912 - 108,468,926 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	114,846,210 - 114,853,374 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	114,848,084 - 114,853,103 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	114,211,573 - 114,218,732 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	106,120,103 - 106,125,121 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Glyctk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	3,936,160 - 3,942,868 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	3,933,964 - 3,939,858 (+)	NCBI	ChiLan1.0	ChiLan1.0

GLYCTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	52,282,866 - 52,290,724 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	52,287,680 - 52,295,495 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	52,230,128 - 52,237,561 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	53,459,271 - 53,466,702 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	53,458,563 - 53,466,702 (+)	Ensembl	panpan1.1		panPan2

GLYCTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	37,462,651 - 37,495,581 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	37,462,659 - 37,465,807 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	37,442,602 - 37,477,128 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	37,811,192 - 37,845,947 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	37,788,578 - 37,845,938 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	37,175,116 - 37,209,637 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	37,583,786 - 37,618,386 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	37,868,469 - 37,902,996 (-)	NCBI		UU_Cfam_GSD_1.0

GLYCTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,433,399 - 34,440,264 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	34,433,403 - 34,440,037 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	37,565,182 - 37,572,167 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GLYCTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	13,648,499 - 13,653,813 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	13,651,024 - 13,653,801 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	153,247,974 - 153,253,449 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Glyctk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	6,089,167 - 6,099,660 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	6,088,702 - 6,095,621 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021727537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021727538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000023233 ⟹ ENSSTOP00000022653

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936529	3,628,822 - 3,635,236 (+)	Ensembl

RefSeq Acc Id:

XM_021727537 ⟹ XP_021583212

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	66,866,696 - 66,872,727 (+)	NCBI
SpeTri2.0	NW_004936529	3,627,194 - 3,632,984 (+)	NCBI

Sequence:

show sequence

GTTCTGCCCACCCGCGAGTACTTCCGGTCGCCAGCGCTGGAAGCTGGGCCCGTAGCTGTGGAAT
GGCAGCCATGGATGCAAGGTGGTGCTGAGAGCAGTGGGGCATGGCTGCAGCCCTTCAGGTCCTG
CCCTGTCTGGTTCGAGCCCCCTTTCGTCAACTCATCTGGGGGGCTCCAATGGCCCGGCTGGCCA
GTGGTGTGGCATTGGCAGAGCATGCACAACAGTTGTTTGAGAGTGCTGTGGGTGCCGTGCAGCC
AGGTCCCATGTTGCAAAAGGCACTGTCTTTGGACCCTGATGGCAGAACACTGAAGGTTCGGGAC
CGGAGCTTTCAGCTGCGGCAAAACCTCTACCTAGTGGGCTTTGGCAAGGCTGTACTGGGCATGG
CAGCAGCAGCTGAGGAGCTACTGGGCCAGCATCTTGTGCAGGGTGTGATCAGCGTTCCCAAGGG
GATCCGTGCTGCCATGGAATGTGCCGGCAAGCAGGAGATGTTGCTGAAACCACACAGCCGTGTC
CAAGTATTTGAGGGTGCAGAGAACAACTTACCGGATCATGATGCACTGCGGGCCGCACTAGCCA
TCCAGCAGCTGGCTGAAGGACTTACAGCTGATGACCTGTTGCTTGTGCTCATTTCAGGTGGAGG
CTCTGCTCTGCTGCCTGCCCCCATCCCACCTATCACACTGGAGGAGAAGCAGATGCTCACTAAG
CTGCTGGCAGCCCATGGAGCCACCATTCAGGAGCTGAATACCATGCGGAAGGCCTTGTCACAAC
TGAAGGGTGGAGGGCTGGCTCAGGCTGCCTATCCTGCCCAGGTGGTGAGTCTGATCCTGTCAGA
TGTGGTGGGGGACCCTGTGGAGGTCATTGCCAGTGGCCCCACTGTGGCCAGCGCCCACAATGTG
CAAGATTGCCTGCACATCCTCAATCGCTATGGCCTTCGTGCTGCCCTGCCTCGTTCTGTGAAGA
CTGTGCTCTCTCGGGCTGACTCTGACCCCCGTGGGCCACACACCTGTGGTCATGTCCTCAATGT
GATCATCGGCTCTAATATGCTGGCATTGGCTGAGGCTCAGAAGCAGGCTGAGTTGCTGGGCTAC
CGGGCCATGGTCCTGAGCACTGCCATACAGGGTGATGTGAAAAGTGTGGCCCAGTTCTATGGAC
TGCTAGCCCGAGTGGCTGGAGCCCGCCTCATCTCATCCACCGCTGGTGCTTCTGTGGAGGAAGA
TGCAAAACTCCATGAGCTGGCAGCTGAGTTCCAGCTCCCAGATCTGAAGCTGGAGGAGGTTCTG
GAGGCTGTGGCAGAGGCTAGGGGCCCAGTCTGCTTGCTAGCTGGCGGTGAGCCCACGGTGCAGC
TGCACGGCTCAGGCAAGGGTGGCCGGAACCAGGAACTGGCCCTGCGTGTTGGAGCAGAGTTAGG
AAGATGGCCACTGGGGCCTATTGATGTGTTGTTTTTGAGTGGTGGCACCGATGGGCAGGATGGG
CCCACAGAAGCTGCTGGGGCCTGGGTCATGCCTGAGCTTACCATCCAGGCTGCTGCTGAGGGCC
TGGATGTGGCTACCTTCCTAGACCACAATGACTCGTACACCTTCTTCTGCCGCCTTCAAGGTGG
AGCACACCTGCTGTACACAGGGCCAACAGGAACCAATGTCATGGACACCCACCTTCTGTTTCTG
CGGCCTCAGTGACATCATCGGTCATATTTTGAGAGTCCAGAAGAGGCATTGGGGCGGGGTCTTA
GGGAATACCAGAGTTGGTCCGCAGGGCCTCACCAGGCTTTAGGGCCTACTTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_021583212	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022653.1
GenBank Protein	KAG3270615	(Get FASTA)	NCBI Sequence Viewer
	KAG3270616	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021583212 ⟸ XM_021727537

- UniProtKB:

I3NE56 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAALQVLPCLVRAPFRQLIWGAPMARLASGVALAEHAQQLFESAVGAVQPGPMLQKALSLDPD
GRTLKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMECAGKQEM
LLKPHSRVQVFEGAENNLPDHDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPITL
EEKQMLTKLLAAHGATIQELNTMRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGP
TVASAHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPRGPHTCGHVLNVIIGSNMLALAEAQ
KQAELLGYRAMVLSTAIQGDVKSVAQFYGLLARVAGARLISSTAGASVEEDAKLHELAAEFQLP
DLKLEEVLEAVAEARGPVCLLAGGEPTVQLHGSGKGGRNQELALRVGAELGRWPLGPIDVLFLS
GGTDGQDGPTEAAGAWVMPELTIQAAAEGLDVATFLDHNDSYTFFCRLQGGAHLLYTGPTGTNV
MDTHLLFLRPQ

hide sequence

RefSeq Acc Id:

ENSSTOP00000022653 ⟸ ENSSTOT00000023233

Protein Domains

MOFRL MOFRL-associated

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023719	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023233.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1480.10	UniProtKB/TrEMBL
	3.40.50.10180	UniProtKB/TrEMBL
InterPro	GK-like_C_sf	UniProtKB/TrEMBL
	GK_N_sf	UniProtKB/TrEMBL
	MOFRL	UniProtKB/TrEMBL
	MOFRL_assoc_dom	UniProtKB/TrEMBL
	MOFRL_protein	UniProtKB/TrEMBL
NCBI Gene	Glyctk	ENTREZGENE
PANTHER	GLYCERATE KINASE	UniProtKB/TrEMBL
	PTHR12227	UniProtKB/TrEMBL
Pfam	DUF4147	UniProtKB/TrEMBL
	MOFRL	UniProtKB/TrEMBL
Superfamily-SCOP	GckA/TtuD-like	UniProtKB/TrEMBL
UniProt	I3NE56	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB