Chmp2a (charged multivesicular body protein 2A)

Gene: Chmp2a (charged multivesicular body protein 2A) Ictidomys tridecemlineatus

Analyze

Symbol:

Chmp2a

Name:

charged multivesicular body protein 2A

RGD ID:

12710248

Description:

ENCODES a protein that exhibits phosphatidylcholine binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); autophagy (ortholog); establishment of protein localization (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN amphisome membrane (ortholog); autophagosome membrane (ortholog); chromatin (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

charged multivesicular body protein 2A, transcript variant X1; charged multivesicular body protein 2A, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,983,013 - 217,986,001 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937062	133,361 - 136,329 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome maturation (ISO)

autophagy (ISO)

endosome transport via multivesicular body sorting pathway (IEA)

establishment of protein localization (ISO)

exit from mitosis (ISO)

late endosome to lysosome transport (ISO)

late endosome to vacuole transport (IEA)

membrane invagination (ISO)

midbody abscission (ISO)

mitotic metaphase chromosome alignment (ISO)

multivesicular body sorting pathway (ISO)

negative regulation of centriole elongation (ISO)

nuclear membrane reassembly (ISO)

nucleus organization (ISO)

plasma membrane repair (ISO)

positive regulation of exosomal secretion (ISO)

protein homooligomerization (ISO)

protein polymerization (ISO)

protein transport (IEA)

regulation of centrosome duplication (ISO)

regulation of mitotic spindle assembly (ISO)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (ISO)

vacuolar transport (IEA)

viral budding from plasma membrane (ISO)

viral budding via host ESCRT complex (ISO)

Cellular Component

amphisome membrane (ISO)

autophagosome membrane (ISO)

chromatin (ISO)

cytosol (ISO)

ESCRT III complex (IEA)

kinetochore (ISO)

kinetochore microtubule (ISO)

lysosomal membrane (ISO)

membrane coat (ISO)

midbody (ISO)

multivesicular body (IEA)

multivesicular body membrane (ISO)

nuclear envelope (ISO)

nuclear pore (ISO)

plasma membrane (ISO)

Molecular Function

phosphatidylcholine binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Chmp2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,983,013 - 217,986,001 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937062	133,361 - 136,329 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHMP2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	58,551,566 - 58,555,105 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	58,551,452 - 58,555,105 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	59,062,933 - 59,066,472 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	63,754,745 - 63,758,298 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	56,106,112 - 56,109,665 (-)	NCBI		Celera
Cytogenetic Map	19	q13.43	NCBI
HuRef	19	55,373,170 - 55,376,723 (-)	NCBI		HuRef
CHM1_1	19	59,056,762 - 59,060,315 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	61,649,242 - 61,652,782 (-)	NCBI		T2T-CHM13v2.0

Chmp2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	12,765,933 - 12,768,704 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	12,765,937 - 12,768,734 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	13,032,006 - 13,034,777 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	13,032,010 - 13,034,807 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	13,617,355 - 13,620,126 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	11,932,198 - 11,934,923 (-)	NCBI		MGSCv36	mm8
Celera	7	10,659,197 - 10,661,968 (-)	NCBI		Celera
Cytogenetic Map	7	A1	NCBI
cM Map	7	7.73	NCBI

Chmp2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	82,731,212 - 82,735,088 (-)	NCBI		GRCr8
mRatBN7.2	1	73,660,045 - 73,662,894 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	73,660,046 - 73,662,452 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	79,040,454 - 79,042,837 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	87,604,795 - 87,607,178 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	80,795,536 - 80,797,919 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	65,540,808 - 65,543,708 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	65,541,322 - 65,543,707 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	66,352,033 - 66,354,941 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	72,889,349 - 72,891,734 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	72,966,677 - 72,969,771 (+)	NCBI
Celera	1	60,177,374 - 60,179,759 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Chmp2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955584	1,156,828 - 1,160,056 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955584	1,156,828 - 1,160,056 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHMP2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	64,837,136 - 64,840,736 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	66,620,025 - 66,623,594 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	55,564,622 - 55,568,214 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	64,377,986 - 64,381,641 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	64,377,986 - 64,381,417 (-)	Ensembl	panpan1.1		panPan2

CHMP2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	99,405,322 - 99,408,257 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	99,405,337 - 99,410,163 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	99,803,589 - 99,806,504 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	100,018,434 - 100,021,349 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	100,019,387 - 100,021,348 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	99,663,797 - 99,666,712 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	99,376,629 - 99,379,542 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	100,131,268 - 100,134,183 (+)	NCBI		UU_Cfam_GSD_1.0

CHMP2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	63,102,156 - 63,104,943 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	63,102,155 - 63,105,032 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CHMP2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	50,827,200 - 50,830,730 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	50,827,284 - 50,830,702 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	4,133,029 - 4,160,880 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chmp2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624832	45,293 - 48,314 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005342403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005342404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005342403 ⟹ XP_005342460

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	217,983,013 - 217,986,001 (+)	NCBI
SpeTri2.0	NW_004937062	133,361 - 136,329 (-)	NCBI

Sequence:

show sequence

GTGACGTCAAGTCGTTTAATCCGGAAACGGCGGCGGCGGAGACGACAGAACCGAGAGGCCTTCG
TTAGTGGGTACGCCAGGGATCTGAGCAAGTGGCGCGTGACCCGGAAGCGGAAGCAAGTTCCTGT
GCCAGCTCCGGCCTGCCAGCGGGCTCCAGCCACCATGGACCTGTTGTTTGGGCGCCGGAAGACA
CCAGAGGAGCTACTGCGGCAGAACCAGCGGGCCCTGAACCGCGCCATGCGGGAGCTGGACCGGG
AGAGACAGAAACTAGAGACCCAGGAGAAGAAAATCATTGCGGATATCAAAAAGATGGCCAAGCA
GGGCCAGATGGATGCTGTGCGCATCATGGCAAAAGACTTGGTGCGTACCAGGCGCTATGTACGC
AAGTTTGTGTTGATGCGCGCCAATATCCAGGCTGTGTCCCTCAAGATACAGACATTGAAGTCCA
ACAACTCAATGGCACAAGCCATGAAGGGCGTTACCAAGGCCATGGGCACCATGAACAGACAGCT
GAAATTGCCACAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGACATG
AAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGGGACGAGGAGGATGAAGAGGAGA
GTGATGCTGTTGTGTCCCAGGTCCTGGATGAGCTGGGACTAAGCCTGACAGATGAACTGTCAAA
TCTCCCCTCCACTGGAGGCTCACTGAGTGTGGCTGCTGGTGGGAAGAAGGCAGAGGCCACAGCT
TCAGCCCTGGCTGATGCAGACGCAGATCTGGAAGAGAGACTCAAGAACCTAAGAAGGGACTGAC
GTCCAGAACAGACACCCAGGGTCTTCACCATGCCCCCTGTAATAAAATTGGACACTTAATCCCA
AA

hide sequence

RefSeq Acc Id:

XM_005342404 ⟹ XP_005342461

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	217,983,166 - 217,986,001 (+)	NCBI
SpeTri2.0	NW_004937062	133,368 - 136,184 (-)	NCBI

Sequence:

show sequence

GCTCCTGCTGGGCCGCAGGTCCCGGGTGGGTGGCGGTGTACGAAGGTTTCTCTAGGCTTAGGTA
TCCAGGCCTGCCAGCGGGCTCCAGCCACCATGGACCTGTTGTTTGGGCGCCGGAAGACACCAGA
GGAGCTACTGCGGCAGAACCAGCGGGCCCTGAACCGCGCCATGCGGGAGCTGGACCGGGAGAGA
CAGAAACTAGAGACCCAGGAGAAGAAAATCATTGCGGATATCAAAAAGATGGCCAAGCAGGGCC
AGATGGATGCTGTGCGCATCATGGCAAAAGACTTGGTGCGTACCAGGCGCTATGTACGCAAGTT
TGTGTTGATGCGCGCCAATATCCAGGCTGTGTCCCTCAAGATACAGACATTGAAGTCCAACAAC
TCAATGGCACAAGCCATGAAGGGCGTTACCAAGGCCATGGGCACCATGAACAGACAGCTGAAAT
TGCCACAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGACATGAAGGA
GGAGATGATGAATGATGCCATTGATGATGCCATGGGGGACGAGGAGGATGAAGAGGAGAGTGAT
GCTGTTGTGTCCCAGGTCCTGGATGAGCTGGGACTAAGCCTGACAGATGAACTGTCAAATCTCC
CCTCCACTGGAGGCTCACTGAGTGTGGCTGCTGGTGGGAAGAAGGCAGAGGCCACAGCTTCAGC
CCTGGCTGATGCAGACGCAGATCTGGAAGAGAGACTCAAGAACCTAAGAAGGGACTGACGTCCA
GAACAGACACCCAGGGTCTTCACCATGCCCCCTGTAATAAAATTGGACACTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005342460	(Get FASTA)	NCBI Sequence Viewer
	XP_005342461	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000023035.1
	ENSSTOP00000031814.1
GenBank Protein	KAG3280923	(Get FASTA)	NCBI Sequence Viewer
	KAG3280924	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005342460 ⟸ XM_005342403

- UniProtKB:

I3NF88 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAK
DLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMME
FERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVA
AGGKKAEATASALADADADLEERLKNLRRD

hide sequence

RefSeq Acc Id:

XP_005342461 ⟸ XM_005342404

- UniProtKB:

I3NF88 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAK
DLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMME
FERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVA
AGGKKAEATASALADADADLEERLKNLRRD

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022368	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000020258.2	UniProtKB/TrEMBL
	ENSSTOT00000042512.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.1230	UniProtKB/TrEMBL
InterPro	Snf7_fam	UniProtKB/TrEMBL
NCBI Gene	Chmp2a	ENTREZGENE
PANTHER	CHARGED MULTIVESICULAR BODY PROTEIN 2A	UniProtKB/TrEMBL
	PTHR10476	UniProtKB/TrEMBL
Pfam	Snf7	UniProtKB/TrEMBL
UniProt	A0A287DE53_ICTTR	UniProtKB/TrEMBL
	I3NF88	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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