Pth2r (parathyroid hormone 2 receptor)

Gene: Pth2r (parathyroid hormone 2 receptor) Ictidomys tridecemlineatus

Analyze

Symbol:

Pth2r

Name:

parathyroid hormone 2 receptor

RGD ID:

12708202

Description:

ENCODES a protein that exhibits parathyroid hormone receptor activity (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (inferred); cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); primary pulmonary hypertension (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	165,022,023 - 165,113,964 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936950	114,317 - 204,718 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936950	114,265 - 181,948 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

primary pulmonary hypertension (ISO)

syndromic intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IEA)

cell surface receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

positive regulation of cold-induced thermogenesis (IEA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled peptide receptor activity (IEA)

G protein-coupled receptor activity (IEA)

parathyroid hormone receptor activity (IEA,ISO)

peptide hormone binding (IEA)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pth2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	165,022,023 - 165,113,964 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936950	114,317 - 204,718 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936950	114,265 - 181,948 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTH2R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	208,359,692 - 208,494,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	208,359,714 - 208,854,503 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	209,224,416 - 209,359,231 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	208,979,801 - 209,067,476 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	209,097,061 - 209,184,736	NCBI
Celera	2	203,039,476 - 203,127,142 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI
HuRef	2	201,071,685 - 201,206,321 (+)	NCBI		HuRef
CHM1_1	2	209,230,414 - 209,365,040 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	208,839,502 - 208,974,285 (+)	NCBI		T2T-CHM13v2.0

Pth2r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	65,317,921 - 65,428,784 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	65,321,215 - 65,428,403 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	65,280,282 - 65,389,625 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	65,282,056 - 65,389,244 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	65,357,831 - 65,435,818 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	65,245,872 - 65,323,086 (+)	NCBI		MGSCv36	mm8
Celera	1	65,801,872 - 65,880,183 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	33.05	NCBI

Pth2r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	74,199,785 - 74,304,326 (+)	NCBI		GRCr8
mRatBN7.2	9	66,706,050 - 66,810,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	66,706,050 - 66,810,036 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	75,224,757 - 75,332,486 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	80,347,604 - 80,450,942 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	78,763,893 - 78,864,581 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	72,052,966 - 72,158,343 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	72,052,966 - 72,157,773 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	70,414,061 - 70,518,866 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	63,942,380 - 64,049,405 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	64,089,361 - 64,196,387 (+)	NCBI
Celera	9	64,101,423 - 64,205,579 (+)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

Pth2r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	6,584,627 - 6,715,337 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	6,584,627 - 6,674,990 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTH2R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	110,969,434 - 111,112,053 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	110,984,410 - 111,128,225 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	95,598,732 - 95,746,699 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	213,722,389 - 213,866,526 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	213,769,735 - 213,866,519 (+)	Ensembl	panpan1.1		panPan2

PTH2R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	16,656,573 - 16,758,313 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	16,678,002 - 16,734,220 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	17,539,128 - 17,640,540 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	16,592,184 - 16,694,239 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	16,592,037 - 16,669,677 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	16,566,302 - 16,646,147 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	16,509,816 - 16,612,231 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	16,519,218 - 16,621,171 (+)	NCBI		UU_Cfam_GSD_1.0

PTH2R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	111,509,531 - 111,598,829 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	111,509,496 - 111,598,308 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	123,124,761 - 123,185,921 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTH2R
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	94,146,254 - 94,284,056 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	94,216,493 - 94,283,743 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	105,066,687 - 105,176,926 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pth2r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	7,501,225 - 7,627,503 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	7,500,586 - 7,627,440 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021721272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000012789 ⟹ ENSSTOP00000011464

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936950	114,317 - 204,718 (-)	Ensembl

RefSeq Acc Id:

XM_021721272 ⟹ XP_021576947

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,032 - 165,113,964 (+)	NCBI
SpeTri2.0	NW_004936950	114,265 - 181,948 (-)	NCBI

Sequence:

show sequence

AGCTGGATTCTGATGGCACCGTTACCATTGAGGAGCAGATCATCCTGGTTATGAAAGCGAAAGT
GCAATGTGAGCTCAACATCACAGCCCAGCTCCAGGAGGGAGAAGGTAATTGTTTCCCAGAATGG
GATGGACTCATTTGTTGGCCCAGAGGAACAGTGGGGAAAATATCAGCTGTCCCATGCCCTCCTT
ATATTTATGACTTCAATCATAAAGGAACCGCCTTCCGACACTGCACTCCCAACGGAACATGGGA
TTTTATTCACAGCTCAAATAAAACATGGGCTAATTATTCAGATTGCTTTCTGCAACCAGATATC
AGCATAGGAAAGCAGGAGTTCTTCAAAAGCCTCCACATCTTGTACACCGTGGGCTACTCCATTT
CCTTGGGTTCCTTGGCTGTGGCCATCCTCATCATCGGTTACTTCAGACGATTGCATTGCACTAG
GAACTATATCCACCTGCACTTATTTGTGTCTTTCATGCTGAGAGCTATAAGCATTTTTGTCAAG
GACAGAGTAGCCCAGGCTCACCTGGGAGTAGAAGAGCTGCAGTCCCTGATAATGCAGGATGACC
TACACAATTCCATTGGAGCACCTTCTGTGGACAAATCACAATATATCGGGTGCAAGATTGCTGT
TGTGATGTTTATTTACTTCTTGGCAACAAACTACTATTGGATCCTCGTGGAAGGTCTCTACCTG
CATAATTTAATCTTTGTGTCTTTCTTTTCGGACACCAAATACCTGTGGGGCTTCATCTTGATTG
GCTGGGGGTTTCCAGTGGCATTTGTTGTGGCCTGGGCTGTGGTGCGAGCAACTCTGGCTGATGC
CAGGTGCTGGGAACTTAGTGCAGGAGACAGGTGGATTTATCAAGCTCCAATCTTAGCGGCTATT
GGGCTTAATTTTATTCTGTTTCTGAACACTGTTAGAGTTCTGGCTACTAAAATTTGGGAGACCA
ATGCAGTCGGGCATGACATGAGAAAACAATACAGGAAACTTGCCAAGTCCACGCTGGTCCTGGT
GCTGGTCTTTGGAGTGCACTACATCGTGTTCATCTGCCAGCCCCACTCCTTCACAGGGCTCTGG
TGGGAGATCCGCATGCACTGTGAGCTCTTCTTCAACTCCTTCCAGGGTTTCTTTGTGTCCATCA
TCTACTGCTACTGCAATGGAGAGGTTCAGGGTGAGGTGAAGAAGATGTGGAGTCGGTGGAATCT
GTCCATGGACTGGAAAAGGACGCCACCATGTGGCAGCCACAGATACGGCTCCGTGCTCACCACT
GTGACTCACAGCACCAGCAGCCATTCCCAGGTGGCTGCCAGCACTCGCCTGGTGCTCCTCTCTG
GCAAAACCGCCAAGACAGCCAACCAACAGCCTGACAGCCATGTAACTTTACCTGGCTATGTGTG
GAGTAACTCGGACCAGGACTGCCTGCCACACTGCATCCAAGAGGAGACTAAGGAAGGTATTGAG
AGGCAGGCAGATGATATTCCAGCGGAGTCTTCCAGGCCAATGGAATTTAGTCTAGTCACAGAAG
TACGCCAAGGAGAAACCAAGGATGTTTTCTGAGTCAACGATTGTGGCAGCTGGGCATGGTGGCG
CATGCCTATAATCCCAGCAGCTCAGGAGGCTGATGCA

hide sequence

RefSeq Acc Id:

XM_040294812 ⟹ XP_040150746

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,024 - 165,113,964 (+)	NCBI

RefSeq Acc Id:

XM_040294813 ⟹ XP_040150747

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,023 - 165,113,964 (+)	NCBI

RefSeq Acc Id:

XM_040294814 ⟹ XP_040150748

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,028 - 165,113,964 (+)	NCBI

RefSeq Acc Id:

XM_040294815 ⟹ XP_040150749

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,027 - 165,113,964 (+)	NCBI

RefSeq Acc Id:

XM_040294816 ⟹ XP_040150750

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	165,022,740 - 165,113,964 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_021576947	(Get FASTA)	NCBI Sequence Viewer
	XP_040150746	(Get FASTA)	NCBI Sequence Viewer
	XP_040150747	(Get FASTA)	NCBI Sequence Viewer
	XP_040150748	(Get FASTA)	NCBI Sequence Viewer
	XP_040150749	(Get FASTA)	NCBI Sequence Viewer
	XP_040150750	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000011464.3
GenBank Protein	KAG3275106	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_021576947 ⟸ XM_021721272
- Peptide Label:	isoform X6
- UniProtKB:	I3MJT4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGTAFRHCTP NGTWDFIHSSNKTWANYSDCFLQPDISIGKQEFFKSLHILYTVGYSISLGSLAVAILIIGYFRR LHCTRNYIHLHLFVSFMLRAISIFVKDRVAQAHLGVEELQSLIMQDDLHNSIGAPSVDKSQYIG CKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFILIGWGFPVAFVVAWAVVRA TLADARCWELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKS TLVLVLVFGVHYIVFICQPHSFTGLWWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQGEVKKMW SRWNLSMDWKRTPPCGSHRYGSVLTTVTHSTSSHSQVAASTRLVLLSGKTAKTANQQPDSHVTL PGYVWSNSDQDCLPHCIQEETKEGIERQADDIPAESSRPMEFSLVTEVRQGETKDVF hide sequence

RefSeq Acc Id:	XP_040150747 ⟸ XM_040294813
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040150746 ⟸ XM_040294812
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040150749 ⟸ XM_040294815
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_040150748 ⟸ XM_040294814
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_040150750 ⟸ XM_040294816
- Peptide Label:	isoform X5

RefSeq Acc Id:

ENSSTOP00000011464 ⟸ ENSSTOT00000012789

Protein Domains

G-protein coupled receptors family 2 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000012785	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000012789.3	UniProtKB/TrEMBL
Gene3D-CATH	4.10.1240.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_2-like	UniProtKB/TrEMBL
	GPCR_2_extracell_dom_sf	UniProtKB/TrEMBL
	GPCR_2_extracellular_dom	UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/TrEMBL
	GPCR_2_secretin-like_CS	UniProtKB/TrEMBL
NCBI Gene	Pth2r	ENTREZGENE
PANTHER	PARATHYROID HORMONE 2 RECEPTOR	UniProtKB/TrEMBL
	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/TrEMBL
	HRM	UniProtKB/TrEMBL
PRINTS	GPCRSECRETIN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_2	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_3	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
SMART	HormR	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
	SSF111418	UniProtKB/TrEMBL
UniProt	I3MJT4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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