Mapk9 (mitogen-activated protein kinase 9) - Rat Genome Database

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Pathways
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Gene: Mapk9 (mitogen-activated protein kinase 9) Ictidomys tridecemlineatus
Analyze
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
RGD ID: 12707230
Description: ENCODES a protein that exhibits ATP binding (ortholog); cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); JUN kinase activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular hyperosmotic response (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); arteriosclerosis (ortholog); FOUND IN cytoplasm (ortholog); perikaryon (ortholog); Schaffer collateral - CA1 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitogen-activated protein kinase 9, transcript variant X1; mitogen-activated protein kinase 9, transcript variant X2; mitogen-activated protein kinase 9, transcript variant X3; mitogen-activated protein kinase 9, transcript variant X4; mitogen-activated protein kinase 9, transcript variant X5; mitogen-activated protein kinase 9, transcript variant X6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,341,905 - 119,392,250 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739551,629 - 602,047 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (IEA,ISO)
cellular hyperosmotic response  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV  (ISO)
inflammatory response to wounding  (IEA)
JNK cascade  (IEA,ISO)
JUN phosphorylation  (ISO)
modulation of chemical synaptic transmission  (IEA)
neuron development  (ISO)
neuron projection development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA)
protein localization to tricellular tight junction  (IEA,ISO)
protein phosphorylation  (ISO)
protein targeting to mitochondrion  (ISO)
regulation of circadian rhythm  (IEA)
regulation of JNK cascade  (ISO)
regulation of protein ubiquitination  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to amine  (ISO)
response to cadmium ion  (IEA,ISO)
response to mechanical stimulus  (ISO)
response to nerve growth factor  (ISO)
response to organic substance  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,341,905 - 119,392,250 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739551,629 - 602,047 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,233,143 - 180,292,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5180,233,143 - 180,292,099 (-)EnsemblGRCh38hg38GRCh38
GRCh375179,660,143 - 179,719,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,595,390 - 179,640,216 (-)NCBINCBI36Build 36hg18NCBI36
Build 345179,595,389 - 179,640,216NCBI
Celera5175,286,573 - 175,345,058 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,385,878 - 174,444,273 (-)NCBIHuRef
CHM1_15179,092,988 - 179,151,485 (-)NCBICHM1_1
T2T-CHM13v2.05180,788,589 - 180,847,539 (-)NCBIT2T-CHM13v2.0
Mapk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,737,558 - 49,777,248 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,737,578 - 49,777,248 (+)EnsemblGRCm39 Ensembl
GRCm381149,846,728 - 49,886,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,846,751 - 49,886,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,660,253 - 49,699,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,690,177 - 49,729,521 (+)NCBIMGSCv36mm8
Celera1154,408,836 - 54,448,385 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.96NCBI
Mapk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,670,750 - 34,711,972 (+)NCBIGRCr8
mRatBN7.21034,169,661 - 34,211,138 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,169,675 - 34,210,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,845,042 - 38,885,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,383,457 - 7,423,947 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,838,708 - 33,879,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
Mapk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408391,094 - 430,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955408391,094 - 430,638 (+)NCBIChiLan1.0ChiLan1.0
MAPK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24175,258,630 - 175,314,810 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15173,422,710 - 173,478,884 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05175,437,167 - 175,495,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,748,381 - 182,801,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,748,381 - 182,795,135 (-)Ensemblpanpan1.1panPan2
MAPK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,443,528 - 1,480,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,443,547 - 1,478,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,491,213 - 1,542,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,400,469 - 1,452,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,400,430 - 1,452,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,353,353 - 1,404,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,451,386 - 1,502,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,691,426 - 1,743,027 (+)NCBIUU_Cfam_GSD_1.0
MAPK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,338,376 - 78,399,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,823,618 - 79,884,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,965,330 - 82,026,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,963,899 - 82,013,659 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,351,365 - 13,412,409 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,999,339 - 43,048,285 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,998,948 - 43,048,392 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000002752   ⟹   ENSSTOP00000002461
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936739562,110 - 599,085 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000021705   ⟹   ENSSTOP00000018001
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936739562,110 - 599,085 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000035546   ⟹   ENSSTOP00000030639
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936739551,629 - 602,047 (+)Ensembl
RefSeq Acc Id: XM_005339336   ⟹   XP_005339393
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213119,341,908 - 119,392,250 (+)NCBI
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364787   ⟹   XP_013220241
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213119,341,907 - 119,392,250 (+)NCBI
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735979   ⟹   XP_021591654
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213119,341,908 - 119,392,250 (+)NCBI
SpeTri2.0NW_004936739551,678 - 599,401 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735980   ⟹   XP_021591655
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213119,341,907 - 119,392,250 (+)NCBI
SpeTri2.0NW_004936739551,678 - 599,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040273742   ⟹   XP_040129676
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213119,341,905 - 119,392,250 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013220241   ⟸   XM_013364787
- Peptide Label: isoform X4
- UniProtKB: M3ZCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005339393   ⟸   XM_005339336
- Peptide Label: isoform X2
- UniProtKB: A0A287DAT2 (UniProtKB/TrEMBL),   M3ZCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591654   ⟸   XM_021735979
- Peptide Label: isoform X1
- UniProtKB: I3N0V5 (UniProtKB/TrEMBL),   M3ZCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591655   ⟸   XM_021735980
- Peptide Label: isoform X3
- UniProtKB: M3ZCQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040129676   ⟸   XM_040273742
- Peptide Label: isoform X5
- UniProtKB: M3ZCQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000018001   ⟸   ENSSTOT00000021705
RefSeq Acc Id: ENSSTOP00000030639   ⟸   ENSSTOT00000035546
RefSeq Acc Id: ENSSTOP00000002461   ⟸   ENSSTOT00000002752
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002755 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002752.3 UniProtKB/TrEMBL
  ENSSTOT00000021705.2 UniProtKB/TrEMBL
  ENSSTOT00000035546.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapk9 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 9 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS JNKMAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287DAT2 ENTREZGENE, UniProtKB/TrEMBL
  I3N0V5 ENTREZGENE, UniProtKB/TrEMBL
  M3ZCQ6 ENTREZGENE, UniProtKB/TrEMBL